1.Diagnostic value of CT scan in kidney lymphoma
Chinese Journal of Urology 2009;30(10):659-662
Objective To discuss the diagnostic value of CT scan in kidney lymphoma. Methods Review the CT findings of 14 cases with kidney lymphoma proved by pathology.Eight cases were male and the other 6 cases were female,the average age was 52-year-old.Nine cases showed abdominal discomfort,2 cases showed abdominal pain,3 cases showed diarrhea,2 cases were accompanied with hematuria and 2 cases were with fever.Using Somatom Plus4 spiral CT and 4-slice Presto multi-slice spiral CT,plain scan and enhanced scan were carried out in 12 cases,arterial phase scan plus parenchymal phase scan were carried out in 2 cases.The direct and indirect signs were analyzed.Results The CT performance of 14 cases.Direct sign: Single node was in 1 case,which manifested uniform density on plain scanning and uniformly on contrast,the border was clear.Multiple nodes were in 6 cases,which presented clear border and lightly enhanced.the kidney's shape had no significantly outer convex.Diffusely invading tumor were in 7 cases,which had the finding of enlarged kidney,lightly enhanced lesions and ambiguous border.Indirect sign:the lymphoma nodes beside abdominal aortor and renal hilus enlaged were in 13 cases,in which the lymphoma nodes enlarged like array were in 4 cases,the lymphoma nodes swelled and fused,enveloped vessels,showed"abdominal aortic submerged sign"were in 3 cases.The lymphoma nodes swelled with uniform and lightly enahanted density were in 13 cases,in which the lymphoma nodes had clear border were in 9 cases.accompanied with sacral vertebra,sacral lymphoma was in 1 case,with perinephrium invasion were in 2 cases.The right kidney Surgically resected was 1 case,biopsy confirmed were 13 cases,pathology reports were all B-cell non-Hodgkin lymphoma. Conclusion For diagnosis of kidney lymphoma,the indirect typical signs have great importance besides direct important signs
2.Level of plasma snperoxide dismutase and effect of superoxide dismntase on patients with lung cancer
Chinese Journal of Primary Medicine and Pharmacy 2008;15(4):588-589
Objective To detect the level of plasma superoxide dismutase(SOD) in patients with lung cancer and effect of chemotherapy(CGM + CBP) on it,and to investigate the role of SOD in the development .of lung cancer. Methods Xanthine oxidation enzyme was availabe to detect the level of plasma SOD in 30 cases of normal control subjects and 29 cases of patients with lung cancer before and after first, second, third cycle of chemotherapy. Resuits The levels of plasma SOD in lung cancer after chemotherapy were lower than those in the control group(P<0.01). The level of plasma SOD in lung cancer after first and second chemo-cycle was higher than that before, but lower than that of control group(P<0.01), the differences between after third chemo-cycle and control group were not significant(P>0.05 ). The differences in squamoun cell carcinoma and adenocarcinoma before chemothrapy and after were not significant (P>0.05 ). The differences in squamoun cell carcinoma and adenocarcinoma and adenosquamoun carcinoma before chemotherapy and after were highly significant (P<0.01 ). The differences in each chemo-cycle were highly significant (P<0.01). Conclusion SOD played an important role in growth, regulation and treatment of lung cancer,and it might be a clinical index in lung cancer.
3.The Practical Value of Serum Prealbumin and Butyrylcholinesterase in Child-Pugh Classification of Liver Cirrhosis
Weigang HUANG ; Yanfen ZHENG ; Xiaochao WANG
Journal of Chinese Physician 2001;0(06):-
Objective To study the practical value of serum prealbumin and butyrylcholinesterase in Child-Pugh classification of liver cirrhosis. Methods 66 serum samples of patients with liver cirrhosis and 50 serum samples of the healthy subjects were collected for detecting prealbumin (PA) level and butyrylcholinesterase (BuChE) activity, as well as hepatic functional indices(serum albumin, total bilirubin and alanine aminotransferase). The patients were classified according to the Child-Pugh score. Results Compared with healthy subjects, the content of PA and the activity of BuChE significantly decreased in the patients with liver cirrhosis. According to the Child-Pugh classification, PA content and BuChE activity in different grades of liver cirrhosis varied obviously. Conclusion The content of serum PA and the activity of serum BuChE had an important guiding significance in diagnosing the extent of liver cirrhosis, which can serve as effective indices for diagnosis of patients'condition and prognostic evaluation of liver cirrhosis.
4.Acarbose decreases the risk of recurrent stroke in impaired glucose tolerance patients with ischemic stroke
Hong WANG ; Jinping LIU ; Xiaochao ZHANG
Chinese Journal of Postgraduates of Medicine 2008;31(10):20-22
Objective To determine wherher acarbose could decrease the risk of recurrent stroke in impaired glucose tolerance(IGT)patients with ischemic stroke.Methods Four hundred and sixteen patients with transient ischemic attack(TIA)or minor ischemic stroke were selected into this trial and participated 75g oral glucose tolerance test(OGTT)1 month after their diagnosis and recovery of the disease.One hundred and nineteen IGT patients were randomly divided into two groups.Patients in pharmaceutical intervention group were treated with acarhose while those in the observation group were not.Seventy patients were selected randomly in those patients without IGT(control group).All patients of the three groups were administered low dose aspirin.Results During 3 years follow-up,8 patients (13.33%)experienced a stroke in pharmaceutical intervention group.The risk of recurrent stroke was decreased significantly compared with that in observation group(P<0.05),and there Was no significant difference between pharmaceutical intervention group and control group (P>0.05). Conclusion Acarbose can degrade the risk of recurrent stroke in IGT patients with ischemic stroke.
5.Application research on ultrasonic blood flow velocity measurement.
Xiaochao ZHANG ; Qing ANG ; Weidong WANG
Chinese Journal of Medical Instrumentation 2014;38(1):50-56
The detection of blood flow velocity has great significance for blood vessel monitoring and the research of cardiovascular pathogenesis. Blood flow velocity measurement based on ultrasonic is becoming more and more popular in doctors and patients compare to several other techniques in nowadays, as they are non-invasive, cheap and fast. Most of the traditional ultrasonic blood flow velocity measurement methods are based on the Doppler frequency shift, but theses methods have some limitations, such as angle dependence, limited spatial resolution and so on. Therefore, blood flow velocity techniques based on non-Doppler frequency shift also get rapid development in recent years. This article mainly summarizes the techniques of blood flow velocity estimation based on ultrasonic in these two aspects.
Blood Flow Velocity
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Humans
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Ultrasonography
6.Renal collecting duct carcinoma: imaging spectrum with CT and MRI
Xiaochao LIANG ; Zhenhua ZHAO ; Boyin WANG
Chinese Journal of Urology 2014;35(4):249-253
Objective To summarize the experience of using CT and MRI to diagnose the renal collecting duct carcinoma.Methods From February 2005 to January 2012,10 cases with renal collecting duct carcinoma,confirmed by pathology,were reviewed retrospectively.The data contained 6 men and 4 women,whose age ranged from 21 to 62 years (mean age 48 years).The flank pain was complained by 7 cases,waist discomfort was complained by 3 cases.In urine laboratory test,positive urine erythrocytes (++++) were found in 6 cases.In 10 cases,7 cases accepted CT examination and 3 cases accepted MRI examination.The growth pattern,lesion location,dynamic enhanced scan phase of the tumor and the way of spreading and metastasis were analyzed based on those CT and MRI images.Results The lesions were located in the left kidney in 6 cases,located in the right kidney in 4 cases.The size of tumors ranged from 4.4 cm×5.8 cm to 7.2 cm× 7.4 cm (mean size 5.7 cm× 6.4 cm).The mass,located in the center of renal parenchyma with irregular shape,showed infiltrative growth pattern.The shape of kidney was normal,whereas the border line between cortex and medulla was indistinct.The tumor involved the renal cortex and medulla in 4cases and involved the renal cortex,medulla,pelvis simultaneously in 6 cases.Among 7 patients who accepted the CT scanning,the solid mass was revealed in 6 cases.On CT plain scanning,the masses demonstrated slightly low or equal density within flaky or patchy low-density necrosis.Two cases showed small punctate calcification within the mass.One case was solid and cystic mass,which the cystic part of the mass showed irregular shape of the liquid-density.Among 3 patients accepted MRI scanning,all masses showed solid characters.The substantial part showed slightly hypointense on T1WI and low signal intensity on T2WI.The necrotic foci demonstrated low signal intensity on T1WI and high signal on T2WI.Dynamic enhanced scan revealed mild to moderate enhanced in the substantive part.The density of signal was lower than the renal cortex and slightly higher than the renal medulla in corticomedullary phase.It enhanced continuously in parenchymal phase,but still lower than the renal parenchyma.It enhanced continuously in the delayed phase,while the cystic or necrotic lesions were not observed the enhancement.Renal artery was surrounded by the mass in 2 cases.Tumor embolus was found in the renal vein in 2 cases,9 cases were noticed with renal hilum and paraortic hyperlymphonodus.The thoracic and lumbar spinal metastasis was found in 1 case and adrenal metastasis was found in another case.All patients underwent radical nephrectomy,that pathological diagnosis was renal collecting duct carcinoma.Conclusions The CT and MRI imaging characteristics of renal collecting duct carcinoma can be described as the mass located in the center of renal parenchyma with the infiltrative growth pattern.In MRI image,it demonstrates low signal intensity on T2WI.And a mild continuously enhanced can be observed on dynamic enhanced scanning.Moreover,the tumor often involves renal hilum,perirenal fat capsule,paraortic lymph node,and shows the tendency of distant metastasis.
7.Preliminary Application of Different Image Fusion Technology in Dual Energy CT for Improving Visualization of Gastric Cancer
Wei WANG ; Xiaochao GUO ; Xiaoying WANG ; Jianxin LIU ; Junzhe YANG
Chinese Journal of Medical Imaging 2015;(12):947-950
PurposeConventional gastric CT provides poor contrast for gastric cancer lesions, the purpose of this study is to investigate the application value of dual energy CT image fusion technology in the improvement of lesion contrast in gastric cancer.Materials and Methods Abdominal dual energy contrast-enhanced CT images of 30 gastric cancer patients were retrospectively analyzed, dual-energy images were reconstructed with different linear and nonlinear fusion settings, contrast between lesions and normal gastric wall, lesion contrast to noise ratio (CNR) were compared among 100 kVp, 140 kVp and different fusion groups, and image quality was evaluated subjectively.Results There were statistically significant differences among the gastric cancer contrast and CNR of 100 kVp, 140 kVp and three linear blending images (F=29.6 and 26.1,P<0.001), with M=0.7 linear fusion group showing the highest CNR. The gastric cancer contrast and CNR was signiifcantly higher with a bandwidth (BW) of 0 HU when compared among the three groups of nonlinear blending images (F=268.5 and 49.5,P<0.001). Moreover, the nonlinear group with a width of 0 HU had a 36% and 47% increase in lesion contrast and CNR over that of a linear blending image. In the subjective evaluation of images, the BW=0 HU nonlinear fusion image was most frequently estimated as the most preferred images for lesion observation of gastric cancer.Conclusion Nonlinear blending with a BW of 0 HU improves display of gastric cancer, and has the potential clinical value to increase the accuracy of staging.
8.Optimization of routine trizol extraction method for promoting the production of serum microRNA
Changxuan CHEN ; Lei WANG ; Wei ZHAO ; Fengzhi SHAN ; Xin WANG ; Xiaochao GAO
Journal of Chinese Physician 2015;17(8):1204-1206
Objective To investigate which methods can promote the serum microRNA extract production.Methods The sera of healthy persons were treated with 10% SDS (sodium dodecyl sulfate) and/or sonication at first,then extracted miRNA by routine Trizol method,or the serum miRNA was just extracted by routine Trizol method.The contents of serum miRNA-218 and miRNA-346 were detected by quantitative reverse transcription polymerase chain reaction (qRT-PCR) technique,and qRT-PCR relative quantities among different groups were compared to evaluate influence of different methods on microRNA extract efficacy.Results Compared to routine Trizol extraction method,the qRT-PCR relative quantities of miRNA-218 and miRNA-346 were improved when serum was treated with 10% SDS and/or sonication at first (P <0.05),which was most obviously improved when treated with 10% SDS combined with sonieation.Conclusions The method that serum was treated with SDS incubation and sonication at first can promote sensitivity of serum microRNA detection.
9.The comparative study of neurological function score and subgroups analysis for rats at different ages after CPR modeling
Xin TIAN ; Jing WANG ; Xinchen ZHAO ; Xiaochao ZHOU ; Feng YAN ; Jingyu HE ; Deyu GUO
Chinese Journal of Comparative Medicine 2014;(9):53-58
Objective The purpose of this study is to select suitable ages of rats for the CPR ( cardiopulmonary resuscitation) animal model.The neurological function score and subgroups analysis are evaluated in 2 month old and 4 month old animal groups.Methods Based on the evaluation of physiological indexes including ECG, blood pressure and neurological function defect score ( NDS) and subgroup analysis, the stability of CPR rats model was compared between 2 month old and 4 month old animal groups.Results The results showed that, the model rate of the ventricular fibrillation was induced by electrical stimulation , the 4 month old group was 87.5%, significantly higher than the 2 month old group, however, there was no significant difference between the two groups in the mortality rate;For the changes of blood pressure during the process of CA( cardiac arrest) induced by electrical stimulation, the 4 month old group was significantly lower than the 2 month old group (P <0.01); for the NDS at each time point after CPR, there was no significant difference between the two groups; however, the NDS subgroup analysis at different time points showed that there were different degrees of differences between the two age groups ( P <0.05) .Comparing with the 2 month old group, the 4 month old group had a stable process during the animal model preparation, had an obvious cerebral blood hypoperfusion phenomenon and aggravation of brain injury after CPR.Conclusion The 4 month old rats are more suitable for preparation of CPR animal mode , the model rate is high, the brain injury aggravate.It is more suitable evaluation for basic research and treatment of CPR.
10.Analysis of children’ s health and influential factors in Nujiang prefecture, Yunnan
Yongchao CHEN ; Fang WANG ; Bin CAO ; Xiaoxi LIU ; Xiaochao XU ; Bo ZHANG ; Xue DING
Chinese Journal of Health Policy 2014;(2):57-64
Objective:To determine children ’ s health status and influential factors in Nujiang prefecture , Yun-nan.Methods:Rickets morbidity rate , growth retardation rate , and low-weight rate were selected as the key indica-tors to calculate the sample size by using four-stage-sampling procedure .The data was collected through questionnaire survey, in-depth interviews, and focus-group discussions .χ2 test and qualitative analysis were used to analyze the quantitative and qualitative data .Results:The infant mortality rate was 13.14 %in 2011, which was 1.1 and 1.15 times more than the national and provincial average .The mortality rate of children under five was 16.35%in 2011, which was 1.05 and 1.13 times more than the national and provincial average .It was also 2.19 times more than the average in developed countries .The prevalence of medium and severe malnutrition in children under five was 2 .32%, which was 1 .54 times more than the national average .The incidence of low birth weight was 1 .41%.The research shows that the rates of rickets , growth retardation , and low-weight were 36.13%, 25.81%and 20.98%,and nutritional diseases are more serious .Conclusion:There are serious health problems for children in Nujiang pre-fecture, especially nutritional diseases .Influential factors include health policy and system , economic development, customs, geography, health service capacity , and parental health knowledge Suggestion:The government should im-prove top-level design , strengthen policy support , and develop the local economy in order to solve the social and poli-cy environment factors .Institutions and human capacity should be strengthened , access and quality of services should be improved , health education should be popularized , and health awareness and behaviors should be improved .