Objective To explore the effect of extended nursing mainly by stoma therapists on the self-care ability of permanent colostomy patients group.Methods Seventy-eight patients with permanent colostomy were equally randomized by random digits table into control group and observation group.The former received routine discharge education by duty nurses and the latter the extended nursing mainly by stoma therapists. Three months after discharge,the exercise of self-care agency scale (ESCA) was used to conduct the assessments for comparisons of two groups.Result The score on ESCA in the observation group was significantly higher than that of the control group (P<0.01).Conclusion The extended nursing mainly by stoma therapists can improve colostomy patients’quality of life effectively and help them more knowledgeable about the stoma knowledge and skills to enhance self-care ability.