Peritumoral edema (PTE) of the metastasis tumor of brain (MTB) refers to the abnormal increase of moisture in the surrounding cerebral parenchyma of the brain tumor. The mechanism of PTE occurrence of MTB is complicated, and the influencing factors are diverse. PTE is one of the key factors that affect patient survival and cure. Researchers from China and overseas believe that it may be related to the expression of the vascular endothelial growth factor (VEGF) or VEGF receptor, aquaporin-4 (AQP-4), matrix metalloproteinase-9, interleukin-6, hypoxia inducible factor-1a, and other molecular biology factors. Studies of these molecular biologi-cal factors provide objective scientific evidence for the prevention, control, monitoring, treatment, and prognosis of PTE of metasta-sized brain tumor. In addition to the traditional dehydration therapy of PTE, the use of PTE-related molecular biological factors pro-vides a new approach for the treatment. AQP-4 agonists or antagonists and VEGF receptor antagonists also have good therapeutic poten-tials. In this paper, the authors reviewed the PTE-related molecular biological factors of MTB.

Objective To investigate the benefit finding for caregivers of patients with cancer and its influencing factors. Methods Totally 330 couples of cancer patients and caregivers were investigated from October 2014 to September 2015 by convenience sampling method. The cancer patients were investigated with the Hospital Anxiety and Depression Scale. The caregivers of cancer patients were investigated with Benefit Finding Scale, Zarit Caregiver Burden Interview, Medical Outcomes Study Social Support Survey. Results The total score of benefit finding was (59.65 ± 11.12) points. Regression analysis indicated that caregivers' education, religious, informational and emotional support, caregiver burden, patients' depression symptom, cancer stage and self-caring were influencing factors of benefit finding for caregivers (t=-3.689-5.913, P<0.01 or 0.05), which explained 30.0% of the variance. Conclusions The caregivers of patients with cancer have a low level of benefit finding. Oriented by influencing factors of benefit finding, the health workers should enhance targeted interventions, promote positive perception in the process of caring, develop the quality of caring and life.

Objective To observe the structure of the visual organ and functional development of marine medaka and to provide a theoretical basis for further studying its behavior. Methods The structure of visual organ of marine medaka was examined, with emphasis on the variations of its eyeball and retina. Results The medaka visual organ developed very rapidly. At the embryonic period, the pigment layer of the eyeball appeared, and there already had a significant eye area. At the first day,the structural development of the eyeball and retina were basically completed. At the 6th day, there was a significant difference of pigment layer and photoreceptor layer between light and dark vision. At the 23th day,the retinal structure was greatly changed, which can explain the reason about the change of medaka from the floating stage to the benthic stage. During from 9 to 14 month-old, the thickness of all layers in the retina decreased, indicating that the vision was degraded. Meanwhile,the kernel layer differentiation was obvious,as vertebral cells showed photoreceptor layer structure closely inlaid with rod cells, that medaka has good light sensitivity and strong visual acuity. The rapid development of medaka visual organ can be recognized as it needs to adapt the surroundings and to keep the life events such as feeding. Conclusions The development process of the visual organ of marine medaka is obvious and can provide a theoretical basis for further study of its behavior, and it may be a good experimental method for studying other related species.

The development of Hainan traditional Chinese medicated diet therapy was surveyed and analyzed. The related suggestions are supplied for the development of traditional Chinese medicated diet therapy in Hainan. The designed questionnaires are set up for the surveys that include the respondents’ awareness of the medicated diet therapy and the current status of the medicated diet therapy markets. A total of 450 questionnaires have been sent and 363 respondents (80.67%) were reveiced and analyzed. The result showed that 49.59% (180/363) of the respondents knew the TCM diet therapy well, 43.80% (159/363) favored TCM diet. More than half of the respondents keep in the beauty maintain, the weight-loss and qi and blood maintain by TCM diet. The respondents showed their own favour when they consumed TCM diet. 44.63% (162/363) of the respondents regarded the effectiveness of the TCM diet as important, and 31.40% (114/363) regarded the flavour or taste of the diet as important. The highest consumption of TCM diet that can be accepted was 160 yuan per person. The reputation of a medicinal restaurant is the most important factor for consumers. To cultivate the professionals for the medicated diet’s services and management is an urgent undertaking. To utilize the specific medicines and foods of Hainan for developing the TCM diet is a positive motives. It is necessary to adopt international standards to strengthen the government’s control over the entirely industrial chain of the TCM diet therapy. It will be prosperous to utilize the characteristic culture to establish the medicinal restaurants in Hainan. They will become the new engines for improving economic, social and cultural development of Hainan free trade.

Objective:To analyze the status of the dyadic coping in spouses of young and middle-age cervical cancer patients undergoing synchronous radiotherapy and chemotherapy, and to explore the influencing factors in bi-directional of patients and their spouses.Methods:With the convenience sampling method, a total of 150 cervical cancer patients undergoing synchronous radiotherapy and chemotherapy who were hospitalized in the Radiotherapy Department of Tianjin Medical University Cancer Institute and Hospital from March 2021 to February 2022 and their spouses were selected. A cross-sectional study was conducted by the Dyadic Coping Inventory, the Lock-Wallace Marital Adjustment Test, the General Self-Efficacy Scale, the Hospital Anxiety and Depression Scale, etc. Besides, multiple linear regression was used to identify predictors of the dyadic coping in spouses of cervical cancer patients undergoing synchronous radiotherapy and chemotherapy.Results:The total score of dyadic coping, marital quality, general self-efficacy, anxiety and depression in spouses of cervical cancer patients undergoing synchronous radiotherapy and chemotherapy were (121.69 ± 19.67), (97.23 ± 25.05), (25.13 ± 5.19), (9.98 ± 3.46), (8.19 ± 4.06) points. The scores of anxiety and depression of cervical cancer patients undergoing synchronous radiotherapy and chemotherapy were (10.57 ± 3.60), (9.10 ± 4.12) points. Multiple linear regression analysis showed that factors of the patients′ anxiety and depression, spouse′s perception of marital quality, spouse′s general self-efficacy, changes in family relationship, family income, and period of radiotherapy were the main influencing factors ( P<0.01), which accounted for 55.7% of total variation. Conclusions:The level of dyadic coping in spouses of cervical cancer patients undergoing synchronous radiotherapy and chemotherapy was medium, the marriage quality remains to be further improved,and its influence factors involved in the bi-directional of patient and spouse, including patients′ anxiety and depression, the changes of the family relationship, period of radiotherapy, spouses perception of marital quality and self-efficacy and family income. Clinical medical staff can improve the level of dyadic coping in spouses of cervical cancer patients undergoing synchronous radiotherapy and chemotherapy by improving their cognition of disease, reducing the incongruence of dyadic illness appraisals, and taking multiple measures to reduce the economic burden felt of the spouses.

OBJECTIVE To investigate the status and effect of influenza vaccination among some elderly population and their cognition of influenza vaccination in Shenzhen Pingshan district， and to provide reference for improving the vaccination willingness of the elderly population. METHODS Descriptive epidemiological method was used to analyze the status quo of influenza vaccination among some elderly populations in Pingshan district； the Logistic regression model was used to analyze the influential factors of influenza vaccination； the serum antibody levels of the elderly population were analyzed before and after influenza vaccination. RESULTS Totally 140 effective survey question naires were collected from elderly. The elderly who participated in the survey had a better cognition of the main transmission mode of the influenza virus， 122 people answered correctly， and the accuracy was 87.1%. Age， knowledge that influenza vaccine should be given once a year and knowledge of Shenzhen’s free vaccination policy were the promoting factors for influenza vaccination behavior among the elderly. The positive rates of the four influenza antibodies （type A H1， type A H3， type B Victoria， type B Yamagata） after inoculation were higher than before inoculation， with statistical significance. The antibody titer levels after vaccination were generally higher than before. CONCLUSIONS The positive rate of antibody testing and antibody titer in the elderly population after influenza vaccination are higher than before， which effectively protects the health of the elderly population. It is necessary to continuously improve the awareness of the elderly population about influenza vaccination and free vaccination policies.

Objective To investigate knowledge,attitude and practice towards the fertility preservation of female cancer patients among clinical nurses in a cancer hospital,and to analyze influencing factors,so as to provide references for clinical implementation of related nursing services.Methods A self-designed questionnaire was delivered to 336 nurses working at a tertiary oncology hospital in Tianjin.Univariate analysis and multiple linear regression were used to analyze the factors influencing the knowledge,attitude,and practice level of female fertility preservation among nurses in a cancer hospital.Results In October 2022,a total of 291 nurses completed the questionnaires.The score of the knowledge,attitude and practice were(46.13±8.66),31.00(29.00,33.00),12.00(8.00,14.00),respectively,and the total score was(88.08±12.78).Multiple logistic regression analysis showed that education level,position,department types and whether or not getting the knowledge about fertility preservation of female cancer patients were the influencing factors for the total scores of knowledge,attitude and practice(P＜0.05).Conclusion Nurses who work at the cancer hospital have a positive attitude towards fertility preservation for female cancer patients,while their knowledge and practice level need be improved.Nursing administrators should attach importance to improving the knowledge level and practical ability of nurses in cancer hospitals to protect the fertility of female cancer patients,so as to promote the development of onco-fertility nursing in the future.