Angiotensin-converting-enzyme inhibitors(ACEI) are generally used in the treatment of cardiovascular system diseases.They are found by epidemiological studies to have an anti-tumor activity and are shown to play various roles in suppressing carcinogenesis and tumor growth,preventing angiogenesis,inhibiting matrix degradation and reducing cancer cachexia.

Objective To investigate the incidence of C-shaped root canal systems in mandibular second perma?nent molar of patients in the First People’s Hospital of Yunnan Province, and compare the success rate between one-and two-visit root canal treatment. Methods Two hundred and sixty mandibular second molars were recruited from the pa?tients in the department of endodontics of our hospital, and teeth with C-shaped root canal were categorized by using radio?graphic classification criteria and the modified Melton’s method. Teeth with C-shaped root canal systems were then random?ly divided into two groups to receive one-or two-visit root canal treatment, and success rates of 6-month post-operation were compared between two groups. Results Eighty out of 260 mandibular second molars exhibited C-shaped canals (30.77%). Radiographic examination showed that 25 teeth belonged to typeⅠ(31.25%), 32 teeth typeⅡ(40.00%) and 23 teeth typeⅢ(28.75%) in two groups. As for modified Melton’s method, the incidence rates were 21.25%, 48.75%, 16.25%and 13.75% for C1,C2,C3a and C3b, respectively, while C4 was not found. The success rates were 78.94% (30/38) and 81.08%(30/37) for A group and B group, respectively, with no statistically significant difference between two groups ( 78.94 vs 81.08, P>0.05). Conclusion Results indicate a frequent incidence of C-shaped root canal system of mandibular per?manent second molars in our hospital. One-visit root canal treatment is an effective way for treating C-shaped canals in man?dibular permanent second molar.

Objective To investigate the changes of serum C reactive protein(CRP) ,tumor necrosis factor alpha(TNF-alpha) and interleukin-17(IL-17) by minocycline ointment on the basis of conventional therapy in the treatment of aggressive periodontitis (AgP) .Methods All 45 cases of AgP patients were randomly divided into two groups ,23 cases in the therapeutic group ,were per-formed scaling and root planning plus local minocycline hydrochloride Ointment medication;22 cases in the control group ,were trea-ted by scaling and root planing only .All aggressive periodontitis patients were detected the serum CRP ,TNF-alpha and IL-17 levels before and after treatment ,and compared with normal controls .Results The serum levels of CRP ,TNF-αand IL-17 in normal hu-man were lower than those of AgP patients before and after treatment(P<0 .05) .After 3 months treatment ,the serum levels of CRP ,TNF-αand IL-17 in AgP patients were significantly lower than those before treatment(P<0 .05) .Conclusion The effect of minocycline on the basis of conventional therapy in the treatment of AgP patient is remarkable ,which can improve the serum level of CRP ,TNF-alpha and IL-17 .

Objective To conduct one-visit or multi-visit root canal treatment for infected root canals ,to observe and analyze the postoperative pain and the periapical healing status and to evaluate the clinical application of one -visit root canal therapy .Meth-ods 80 teeth diagnosed as chronic apical periodontitis were recruited .40 cases were included in one-visit root canal treatment group and the other 40 cases in multi-visit group with calcium hydroxide as an interapoinment medicament .Main clinical assessments in-cluded postoperative pain ,postoperative X ray and 6 months′periapical healing response .Results There there was no statistically significant difference between the groups regarding postoperative pain (one-visit group 37 .5% ,multi-visit 35 .0% ,P>0 .05) and 6 months′periapical healing response(one-visit group 81 .6% ,multi-visit 80 .6% ,P>0 .05) .Conclusion One-visit root canal treat-ment has the same clinical effect(postoperative pain and periapical healing ) as multi-visit on infected root canals and has the clinical feasibility of routine use .

Somatostatin,a cyclopeptide hormone,is generally distributed in vivo.Some studies have indicated that somatostatin can reduce proinflammatory cytokine in hepatic stellate cells and extracellular matrix,and inhibit their proliferation and contraction,promote their apoptosis.It can also regulate the function of Kupffer cells,influence the homing of hepatic stem cells.Somatostain has therapeutic effect on liver fibrosis,especially on the liver fibrosis caused by schistosoma mansoni.

Objective To compared the posterior slop between tibial plateau and meniscus in Chinese population for determining the angle of tibial osteotomy during total knee replacement(TKA).Methods Posterior slop of tibial plateau and meniscus in sixty Chinese volunteers were measured on sagital view of MRI image.Results The values of posterior slop of tibial plateau and meniscus were 9.87??1.56?and 0.96??0.09?,respectively.The two angle revealed remarkable difference (P

Tooth eruption is a series of complicated physiological processes occurring once the crown is formed completely, as well as when the tooth moves toward the occasion plane. As such, the tooth moves through the alveolar bone and the oral mucosa until it finally reaches its functional position. Most studies indicate that the process of tooth eruption involves the alveolar bone, dental follicles, osteoclasts, osteoblasts, and multiple cytokines. Dental follicles regulate both resorption and formation of the alveolar bone, which is required for tooth eruption. Furthermore, root formation with periodontal ligament facilitates continuous tooth eruption. However, the exact mechanism underlying tooth eruption remains unclear. Hence, this review describes the recent research progress on the cellular and molecular mechanisms of tooth eruption.
Dental Sac ; Humans ; Osteoblasts ; Osteoclasts ; Periodontal Ligament ; Tooth ; Tooth Eruption ; physiology ; Tooth Root

A method was evaluated for determination of twenty-one doping (including nandrolone, boldenone and methandienone) in human urine by gas chromatography-high resolution mass spectrometry. Samples were prepared by liquid-liquid extraction, concentrated, TMS derivatization and limit of detection at ng x mL(-1) by MID/GC/HRMS. According to the code of the World Anti-Doping Agency (WADA), precision and recoveries of the procedure were evaluated by replicate analysis (n = 6), the recoveries in the range of 66%-103%, with the RSD below 10.0%. The precision within the day of the method with three different concentrations was also determined RSD were less than 9.5%, 10.0% and 9.7%.

OBJECTIVE: To investigate the effects of different concentrations of curcumin on secretion of adiponectin (APN) and interleukin-6 (IL-6) in human adipose tissues cultivated in vitro. METHODS: Seven male patients with kidney stones were admitted. Abdominal subcutaneous adipose tissue and perirenal adipose tissue were collected from the operating-patients, and were cultivated with different concentrations of curcumin (10 and 100 microg/ml) in vitro. The contents of APN and IL-6 in the culture medium of adipose tissue cells were measured by enzyme-linked immunosorbent assay (ELISA) after they were cultured for 6 and 24 hours. RESULTS: Compared with the blank control group, the content of APN in the adipose tissue culture medium was increased by 100 microg/ml curcumin (P<0.05) after 6-hour culture, and the content of IL-6 was significantly decreased by 100 microg/ml curcumin after 6- and 24-hour culture (P<0.05). CONCLUSION: 100 microg/ml curcumin can increase APN secretion and decrease IL-6 secretion in human adipose tissues cultivated in vitro.

Objective To comparatively study the characteristics of 3 kinds of culture substrates of human odontogenic induced pluripotent stem cells(iPSCs).Methods The human odontogenic iPSCs were cultured by 3 kinds of substrates:mouse embryonic fibroblasts(MEF),matrigel and recombinant human vitronectin(VTN-N).The iPSCs growth situation was compared among three groups.Results The preparation time of these 3 kinds of substrates was 14,3,1 hlespectively,and,the difference was statistically significant (P＜0.05).The iPSCs reprogramming time was (30± 1.6),(26 ± 2.1),(27 ± 1.4) d,lespectively,wht that in the MEF group significantly higer than in other two groups (P＜0.05).The reprogramming efficiencies were 0.3 ％ ± 0.03 ％,0.56 ％ ± 0.08 ％,0.7 ％ ± 0.02 ％ respectively (P＜ 0.05).Three kinds of substrate could better support iPSCs growth and make them to maintain un-differentiation status.Conclusion with no heterologous animal components,and the adrantaga of simple pleparation,oonfrollable standard and shorter gramming time is easy to prepare,the standard is controllable and the reprogramming time is shorter,which is an ideal substrate for supporting iPSCs growth.