OBJECTIVE To study the characteristics of articles,citations and authors in Chinese Journal of Nosocomiology(Chin J Nosocomiol).METHODS The data about articles,citations and authors of Chin J Nosocomiol from 2005 to 2006 were collected and analyzed in terms of bibliometric parameters.RESULTS There were 1365 papers published in Chin J Nosocomiol during 2 years and papers with funded projects accounted for 12.3%.The average number of articles per issue was 57,the average publishing cycle of the articles was 8.4 months;87.1% of which shared with co-authors;the cooperation ratio was 3.57.The authors comed from 31 provinces.The papers with citation accounted for 68.9%and 92.3% of all the citations came from journals.The Price's indicator was 82.0%.CONCLUSIONS Chinese Journal of Nosocomiology,an academic journal of high quality,with strong influence,pushes the subject of Nosocomiology in China forward.

OBJECTIVE:To explore the effects of olmesartan medoxomil on blood pressure variability(BPV)and vascular en-dothelial function of patients with mild and moderate essential hypertension. METHODS:Sixty patients with mild and moderate es-sential hypertension were included in study group,and other 60 healthy volunteers were included in control group. Study group was given olmesartan medoxomil 20 mg orally,qd,for 4 weeks,followed by same dose if their SBP≤140 mmHg and DBP<90 mmHg till 12th weekend;those patients with SBP>140 mmHg or DBP≥90 mmHg received double dose till 12th weekend. Aver-age blood pressure,BPV,FMD and NMD of study group were measured before and after treatment as well as the changes in se-rum concentrations of NO and ET,and then compared with control group. RESULTS:Compared with before treatment,average blood pressure,BPV and ET level of study groups were decreased significantly after treatment,serum level of NO was increased significantly,while FMD and NMD were improved significantly,with statistical significance (P<0.05);there was no statistical significance,compared with control group (P>0.05). There were 3 cases of mild diarrhea and 2 cases of mild dry cough,and they relieved after medication withont speical treatment. CONCLUSIONS:Olmesartan medoxomil can play a good effect on de-creasing blood pressure and is tolerable. It can also improve the vascular endothelial function.

Objective To study the relationship between cerebral vascular disease (CVD) and meteorological factors. Methods From 1998 to 2002, 6186 patients with CVD in Qingdao urban were studied. There were 1179 cases of intracerebral hemorrhage (CH), 4821cases of cerebral infarction (CI) and 186 cases of subarachnoid hemorrage (SAH). The relationship between the onset of CVD and meteorological factors including temperature, air pressure, relative humidity, wind velocity was analyzed by circular distribution analysis, Pearson correlation and multiple stepwise regression. Results High incidence of CH was found in winter and the mean angle was in January ((P

0.05) after storing at room temperature less than 4 hours.Its germicidal rate decreased obviously after storing at room temperature more than 8 hours.The(germicidal) efficacy was enhanced with the up of temperature and down of pH,and sharply down with the existence of organic substances.(CONCLUSIONS) Garlic solution can kill the V.parahaemolyticus.Its storing time as well as the temperature,pH,and organic substances can influence the germicidal efficacy.

Objective To investigate the effect of propofol on ketamine-induced cognitive dysfunction and neuronal apoptosis in hippocampus in aged rats. Methods Thirty-two male SD rats aged 18-24 months weighing 380-470 g were randomly divided into 4 groups ( n = 8 each) :control group (group C);propofol group (group P);ketamine group (group K) and propofol + ketamine group (group PK). Propofol 30 mg·kg-1·h-1 or/and ketamine 40 mg· kg-1·h-1 were infused for 2 h once a day for 7 consecutive days. After the last day of drug administration cognitive function was assessed using Morris water maze (escape latency and the number of animals' swimming across the platform). The animals were sncrificed after water naze test and their hippocampi were removed for determination of neuronal apoptosis (by TUNEL) and caspase-3 expression (by immuno-histochemistry) in hippocampal CA1 region. Results There was no significant difference in escape latency and the number of the animals,swimming across the platform, the neuronal apoptotic rate (the number of apoptotic neurons/the number of total neurons) and caspase-3 expression between group C and P. In group K and PK the escape latency was prolonged,the number of animals' swimming across the platform was decreased, neuronal apoptotic rate increased and the caspase-3 expression up-regulated as compared with group C. The ketamine-induced changes were significantly attenuated by coadministration of propofol in group PK. Conclusion Coadministration of propofol can ameliorate ketamine-induced cognitive dysfunction and hippocampal neuronal apoptosis.

ObjectiveTo discuss the clinical characteristics and therapeutic strategy of acute epidural hematoma(EDH) with mixed density on CT.MethodsThe clinical data of 45 patients with acute EDH with mixed density on the first CT after trauma were analyzed retrospectively.Acute EDH form trauma with mixed density on CT images were compared with those which had homogenesis density on CT images at the same time.ResultsThe opportunity of increasing size of hematoma and the mortality was significantly higher in mixed density hematoma( 82.1％,16.2％ )than that of homogenesis density( 17.7％,2.3％ ) ( all P ＜ 0.01 ).ConclusionEDH with mixed density was a hyperacute EDH.The operation for acute EDH from trauma with mixed density on CT image should be prompt.

Objective To investigate the effect of health literacy on stroke education in patients with ischemic cerebrovascular disease and their family members.Methods Health literacy questionnaire was used to conduct the health literacy questionnaire survey for patients with ischemic cerebrovascular disease and their family members.The respondents received stroke education randomly through neurologists' explanation or self-reading.The corresponding questionnaire was used to evaluate the mastering of the content of stroke education for the respondents.Results The complete data of 42 patients with ischemic cerebrovascular disease (34 ischemic stroke and 8 transient ischemic attack) and 57 family members of the patients with ischemic cerebrovascular disease were collected and enrolled in the analysis.The good health literacy score group (＜ 10) and the poor health literacy score group (≥ 10) were 61 and 38 subjects respectively.The proportions of younger age (x2 =16.410,P ＜0.001) and high school or above (68.85％ vs.23.68％ ;x2 =19.25,P ＜ 0.001) of the former were higher than those of the latter,and the proportion of patients (32.79％vs.57.89％;x2 =6.043,P=0.014) was significantly lower than that of the latter,but there was no significant difference in the proportion of the males between the two groups (55.74％ vs.44.74％ ;x2 =1.134,P =0.287).Multivariate logistic regression analysis showed that health literacy was independently associated with the age of respondents (≤40 years:odds ratio [OR] 7.753,95％ confidence interval [CI]1.208-49.740; P=0.031) and the level of education (high school and above:OR,3.993,95％ CI 1.305-12.218; P=0.015),and it was not correlated with gender and role.Those with good stroke education score (≥7)and poor stroke education score (＜7) were 57 and 42,respectively.The proportions of younger age (x2 =17.095,P ＜0.001),high school and above (70.00％ vs.23.08％ ;x2 =20.836,P ＜ 0.001),and good health literacy score (88.33％ vs.20.51％;x2 =45.968,P＜0.001) were significantly higher than those of the latter,while there were no significant differences in the proportions of gender,role,and stroke education.Multivariatelogistic regression analysis showed that only the good health literacy was independently associated with the stroke education score (OR 20.147,95％ CI6.089-66.655; P＜0.001).Conclusions Health literacy can significantly affected the effect of the stroke education in patients with ischemic cerebrovascular disease and their family members.In the development of individualized stroke education program,it should be considered.

Quality of care is key to medical safety which has a close bearing on patients’life and health,and on the branding and efficiency of the hospital.Medical safety is one of the key indicators of the overall performance appraisal of the hospital.This novel type of nurse-physician collaboration,abandoning the traditional model of health care,is a new integrated model of health care which improves the overall quality of care,enhances medical safety and patient satisfaction.This paper described in detail the implementation methods and steps of the collaboration,the progress of such a collaboration and its contribution to medical safety are also discussed.

BACKGROUND: Bronchial asthma is one of those diseases that are significantly affected by meteorological factors. There is close relationship between asthma attack and meteorological factor. There have been some studies on the relationship between asthma and meteorological factors at home and abroad, but the results are various due to different area conditions.OBJECTIVE: To analyze the relationship between asthmatic attack and meteorological factors in children in Qingdao city.DESIGN: Observational experiment.SETTING: The Affiliated Hospital of Qingdao University Medical College.PARTICIPANTS: Altogether 445 inpatient children, 307 males, 138 females, aged ＜ 14 years, who were diagnosed of asthma attack definitely, of the Affiliated Hospital of Qingdao University Medical University, Qingdao Haici Hospital,Qingdao Children Hospital between January 1st 2000 and December 31st 2004 were retrieved.METHODS: The asthmatic attack time of 445 children patients with asthmatic attack of Qingdao city and concurrent month mean temperature, air pressure, relative humidity, wind speed and other meteorologic al data were collected.Seasonal rhythm of asthmatic attack in children and the relationship between asthmatic attack and meteorological factors were analyzed with circular distribution analysis and linear regression analysis, respectively.MAIN OUTCOME MEASURES: ①Month attack information of 445 asthma patients. ② Circular distribution analysis results of asthmatic attack time. ③ Linear regression analysis results about the relationship between asthma attack and meteorological factors.RESULTS: ① Data revealed that asthmatic attack in Qingdao city focused on November, December, January and February, which took up 47.9% of total amount in that year. There were 307 male patients (incidence 3.12%)in a year,female patients only 138 cases (incidence 1.51%), which revealed that boys have a higher incidence of asthma attack than girls. ②The peak season of incidence of asthmatic attack was found in winter and peak season for male and female patients was in January and December, respectively (P ＜ 0.05). ③ Higher incidence of asthmatic attack of children was related with higher air pressure, lower temperature, lower relative humidity(r =0.435, -0.320, -0.296, all P ＜ 0.05).CONCLUSION: The incidence of asthma attack presents seasonal rhythm in Qingdao city and it is influenced by climate conditions. Therefore, enough consideration of meteorological factors should be paid on preventive works for asthma.

BACKGROUND:Behavioral problems among preschool children affect the quality of life in childhood, and it may predict psychiatric disorders in adulthood.OBJECTIVE:To investigate the correlation of behavioral problem occurrence with gender and breastfeeding in children aged 4-5 years old.DESIGN: A stratified random cluster sampling investigation.SETTING:Department of Child Health Care,Affiliated Hospital of Medical College of Qingdao University,and Department of Preventive Medicine, Medical College of Qingdao University.PARTICIPANTS:Totally 600 children (301 boys and 299 girls) aged4-5 years old from 10 kindergartens in 4 districts in Qingdao city were chosen by stratified random cluster sampling during May in 2004.They. all used to be full-term infants of natural labor.METHODS:Achenbach Child Behavior Checklist (CBCL) for parents and self-made inventory scale influencing children's behavior were adopted. Behavioral problems were dependent variables whereas feeding category and breastfeeding duration were independent variables. The effects of feeding category in the first 4 months of life and breastfeeding duration on children's behavior were examined by single factor and multiple factors logistic regression (backward selection).MAIN OUTCOME MEASURES:Breastfeeding condition, breastfeeding duration and behavioral development.RESULTS:According to intention-processing analysis, 600 children 14.2% (85/600) among the 600 children investigated. It was 17.94%(54/301) in males and 10.4% (31/299) in females,with a significant indicated that boys who had been fed on "more infant formula than problem occurrence (OR=2.72,4.29). Breastfeeding duration ≥9months was a protective factor for males (OR=0.43) Girls who feeding duration ＜ 1 month had a risk of behavioral problem ocfeeding duration were set as independent variables and with or without behavioral problems was set as dependent variable to perform multiand breastfeeding duration ≥ 9 months were the risk factors and protective factors of behavioral problem occurrence for males (OR=3.76,ioral problem occurrence for females (OR=2.55,7.79,7.79), which were tective factors of behavioral problem occurrence for males (OR=3.48,behavioral problem occurrence for females ( OR=2.49,9.81,12.89).CONCLUSION:Male is a risk factor of behavioral problems;less breastfeeding and shorter breastfeeding duration are the risk factors of behavioral problem occurrence in children aged 4 to 5 years.