1.Effects of Helium-oxygen Mechanical Ventilation on Histomorphology in ALI Animal Models
Xiongjian XIAO ; Jiandong LIN ; Guo LIN
Journal of Medical Research 2006;0(04):-
Objective To investigate the effect of Helium-oxygen mechanical ventilation on histomorphology in acute lung injury(ALI)animal models.Methods To investigate the changes of histomorphology in ALI rat models caused by sepsis by comparing air-oxygen mixture mechanical ventilation with helium-oxygen mixture mechanical ventilation.Results Helium-oxygen mechanical ventilation has no influence on the change of lung histomorphology.Conclusion Helium-oxygen mixture mechanical ventilation could not improve lung histomorphology.Helium-oxygen mixture mechanical ventilation has no protective effect on ALI animal models.
2.Effects of Helium-oxygen Mechanical Ventilation on Respiratory Mechanics and Oxygenation in ALI Animal Models.
Xiongjian XIAO ; Jiandong LIN ; Guo LIN
Journal of Medical Research 2006;0(09):-
Objective To investigate the effects of Helium-oxygen mechanical ventilation on respiratory mechanics and oxygenation in ALI animal models.Methods To investigate the changes of respiratory mechanics and oxygenated indexs in acute lung injury rat models caused by sepsis at different PEEP by comparing air-oxygen mixture mechanical ventilation with helium-oxygen mixture mechanical ventilation.Results 1.Helium-oxygen mechanical ventilation could not improve respiratory mechanical indexs in ALI animal models(airway peak pressure、mean airway pressure、platform pressure、dynamic compliance、airway resistance、flow rate of peak value).On the contrary,in the condition of high level of PEEP,some indexs became worse,such as depress of dynamic compliance(P
3.A second ERCP for the failure of pre-cut ERCP
Xiao ZHANG ; Yinghui GUO ; Xiuying LIN
Chinese Journal of Digestive Endoscopy 2014;31(4):210-212
Objective To study the therapeutic value of a second ERCP for the patients with failure of pre-cut ERCP.Methods A total of 167 cases of pre-cut ERCP failure were recruited to the study,among which 109 cases were diagnosed as common bile duct stones and/or benign papillary stenosis,and 58 cases as biliopancreatic lesion.ERCP failed with standard intubation for more than 20 minutes,even with pre-cut or fenestration.A second ERCP was preformed after rest of 3-5 days.The position sequence of intubation for most patients was horizontal,the front and rear.Results The success rate was 79.6% (133 cases) for the patients with a second ERCP,85 patients received the procedures via the horizontal intubation,36 via anterior,and 12 via posterior intubation.The treatments were performed after successful completion of the endoscopic cannulation.One patient had retroperitoneal infection with duodenal perforation,another patient had severe pancreatitis,who were cured by the intervention methods.Conclusion The success rate of a second ERCP is high with proficient intubation skills.
5.Genealogy of mucopolysaccharidosis II.
Li-lin GUO ; Yan-lin ZHU ; Xiao-wei YAN
Chinese Journal of Cardiology 2013;41(5):438-439
Adolescent
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Child
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Child, Preschool
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Female
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Humans
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Male
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Mucopolysaccharidosis II
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genetics
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Pedigree
6.Research progress in the study of brain microdialysis in glioma.
Lin LIU ; Xiang-Yi ZHANG ; Yao XIAO ; Xing-Guo ZHANG
Acta Pharmaceutica Sinica 2014;49(4):450-456
Glioma is the most common form of brain cancer. Despite recent advances in the treatment of solid tumors, there are few effective treatments for malignant gliomas due to its infiltrative nature. It has important significance to improve the treatment of glioma through in-depth understanding the intracerebral metabolic characteristics and pharmacokinetics of chemotherapeutics. Brain microdialysis (B-MD), an effective method to monitor central nervous system anticancer drug disposition, conditions of drugs through the blood-brain barrier, basic pathophysiologic metabolism, bioactive compounds and the changes of neurotransmitter in brain, provides the unique opportunity to allow the simultaneous determination of unbound concentrations of drugs in several tissues, and directly measure gliomas biochemistry continuously. B-MD has been able to monitor the change of brain drugs, metabolites and neurotransmitters, dynamic analysis of the drug concentration and pharmacological effect after administration, pharmacodynamic interaction between drugs, receptor mechanism of drug transport, as well as feedback information of internal environment. B-MD is expected to provide reference for clinical individual chemotherapy of glioma, but also provide powerful tools for the evaluation of new anticancer drugs in vivo. In this review, a comprehensive overview of B-MD for studies on glioma is elucidated with special emphasis on its application to neurochemistry and pharmacokinetic studies.
Animals
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Antineoplastic Agents
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pharmacokinetics
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Blood-Brain Barrier
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Brain Neoplasms
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metabolism
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Glioma
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metabolism
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Humans
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Magnetic Resonance Spectroscopy
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Metabolomics
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methods
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Microdialysis
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methods
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Neurotransmitter Agents
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pharmacokinetics
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Pharmaceutical Preparations
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metabolism
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Positron-Emission Tomography
7.A case of child myiasis.
Guo-guang XIAO ; Jian-jun DENG ; Lin LIAO
Chinese Journal of Pediatrics 2010;48(9):719-719
Child, Preschool
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Humans
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Male
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Myiasis
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diagnosis
8.Approach to the patient of subacute thyroiditis combined with Graves' disease
Lian HUANG ; Xiangjin XU ; Yiyang LIN ; Wen GUO ; Jianpeng XIAO
Chinese Journal of Endocrinology and Metabolism 2015;31(4):363-365
Simultaneous concurrence of subacute thyroiditis and Graves' disease is rare.We present one case of subacute thyroiditis with Graves' disease and combine with other reports to explore the clinical characteristics and therapeutic considerations.If subacute thyroiditis is considered coexisting simultaneously with Graves' disease,radioactive iodine uptake,thyroid autoantibody,fine-needle aspiration of thyroid gland,thyroid nuclide imaging examination,etc,should be done to make correct diagnosis and to adjust the therapeutic plan.
9.Novel nerve cell scaffold materials for repair of spinal cord injury Current appfications and future prospects
Nan LIANG ; Xianfeng WANG ; Xiao ZHANG ; Guo CHEN ; Lin OU
Chinese Journal of Tissue Engineering Research 2009;13(25):4993-4996
At present, the research regarding repair of spinal cord mainly focuses on tissue engineering. Neural tissue engineering materials provide three-dimensional template for tissue regeneration and also environment for synthesis of extracellular matrix. This paper summarizes the types of nerve transplant materials and the research progress in application for treatment of spinal cord injury, so as to provide theoretical evidence for repair of spinal cord injury. But some problems exist in application of nerve cell scaffold materials for repair of spinal cord injury: poor mechanical properties lead to slow degradation speed, causing difficulties in tissue reconstruction with respect to velocity and in subsequent reconstruction of porous three-dimensional scaffold. In recent years, novel biomaterials with specific repair function have been made by the engineering method through combining the biological molecule with specific signal identification function and available materials, which is an advanced projeot in the current field of biomaterials.
10.Effect of expression of P-glycoprotein in tumor tissue on analgesic efficacy of morphine and buprenorphine in advanced cancer patients with pain
Jun WANG ; Yiping HU ; Xiao LI ; Shudong YANG ; Lin GUO
Chinese Journal of Anesthesiology 2010;30(10):1212-1215
Objective To evaluate the effect of the expression of P-glycoprotein (P-gp) in tumor tissue on analgesic efficacy of morphine and buprenorphine in advanced cancer patients with pain. Methods One hundred and fifty advanced cancer patients with pain aged 51-64 yr weighing 54-65 kg were included in this study. The expression of P-gp was negative in the tumor tissue in 50 patients (group M1 and B1, n = 25 each) and positive in 100 patients (group M2 ,M3 ,and B2 ,B3, n =25 each). The PCA regimen for the 6 groups were listed in the table .Pain was assessed with VAS scores (0 = no pain, 10 = worst pain) and venous blood samples were taken for determination of blood morphine/buprenorphine concentrations at 4, 12, 24 and 48 h of PCIA. Results The six groups were comparable with respect to age, body weight, M/F sex ratio, types of cancer, baseline pain level and education. The analgesic efficacy of morphine and buprenorphine was better ( VAS scores were significantly lower)in P-gp expression negative patients (group M1 and B1 ) than in P-gp expression positive patients (group M2 and B2 ). Higher doses of morphine and buprenorphine provided better analgesic efficacy in P-gp expression positive patients in group M3 and B3 than in group M2 and B2. Plasma morphine and buprenorphine concentrations were comparable between group M1 , B1 and M2, B2 and were significantly higher in group M3 and B3 at each time point. Conclusion Positive P-gp expression in the tumor tissue can decrease the analgesic efficacy of morphine and buprenorphine in advanced cancer patients with pain.