Antigens, CD ; metabolism ; Diagnosis, Differential ; Epstein-Barr Virus Infections ; Herpesviridae Infections ; Humans ; Immunohistochemistry ; Lymphoma ; classification ; immunology ; pathology ; virology

Objective To explore the response inhibition ability of oppositional defiant disorder symptoms children. Methods Subjects were 27 oppositional defiant disorder symptoms children and 27 normal children. They were asked to complete the stop signal task,go/no go task and the Simon task. Results The delay time of stop reaction (SOA,(260.27 ±69.12)ms) and go reaction time( (554.31 ±55. 81 )ms)of the oppositional defiant disorder symptoms children were shorter than the control group, the difference was significant (P＜0. 05). However,the stop reaction and interference control ability were no significant difference between these two groups. Conclusion Oppositional Defiant Disorder symptoms children's poor prepotent response inhibition ability is cognitive mechanism of their impulsive behaviors.

Diagnostic Techniques and Procedures ; standards ; Humans ; Immunohistochemistry ; Lymphoma ; classification ; diagnosis ; pathology ; Pathology ; education ; standards ; Practice Guidelines as Topic ; Reference Standards

Carcinoma, Non-Small-Cell Lung ; diagnosis ; genetics ; metabolism ; Gene Rearrangement ; Humans ; In Situ Hybridization, Fluorescence ; Lung Neoplasms ; diagnosis ; genetics ; metabolism ; Receptor Protein-Tyrosine Kinases ; genetics ; metabolism

Antigens, CD20 ; metabolism ; Diagnosis, Differential ; Hodgkin Disease ; metabolism ; pathology ; Humans ; Ki-1 Antigen ; metabolism ; Lymphoma, Large B-Cell, Diffuse ; metabolism ; pathology ; Lymphoma, Large-Cell, Anaplastic ; metabolism ; pathology ; Lymphoproliferative Disorders ; metabolism ; pathology ; T-Lymphocytes ; metabolism ; pathology

Encephalopathy of prematurity is still an important reason which affects the survival and quality of life of preterm infants. During hospitalized in neonatal intensive care unit(NICU),a variety of environmental factors such as noise,light,too much tactile stimuli,pain,and maternal - infant separation all will affect the development of preterm infants' brain,leading to encephalopathy of prematurity. Therefore,need to attach importance to the effects of NICU environment on the growth and development and the neurological function of preterm infants,try to optimize the environment of NICU,to reduce the incidence of brain injury of prematurity,improve the long - term prognosis of pre-term infants.

BACKGROUND:Scaffold materials are the important part of tissue engineering bone, and the ideal biodegradation speed of the scaffold materials can be in accordance with the regeneration speed of bone formation in order to achieve a long-term stability. OBJECTIVE:To summarize the biodegradability of different types of currently available scaffold materials and its relationship with bone formation. METHODS:The PubMed and CNKI database were searched by the first author using the key words of “tissue engineering bone, composite scaffold, scaffold degradation” in English and Chinese for articles addressing biodegradability of scaffold materials and its relationship with bone formation published during January 1996 and December 2013. RESULTS AND CONCLUSION:Many scaffold materials under organic, inorganic and organic-inorganic categories have been available and the current studies focus on inorganic materials and organic-inorganic composite materials.In vivo andin vitro studies indicate the different characteristics and relative merits of these scaffold materials. Organic materials have a relatively slow degradation rate while inorganic materials can completely degrade but have an insufficient mechanical property. For organic-inorganic composite materials, further studies are needed.

Objective:To investigate the effects of mycophenolate mofetil(MMF)on the expression of endothelial CD40L and lymphocyte-endothelium adhesion.Methods:HUVEC was used for adhesion assay and CD40L detection.The effect of mycophenolic acid(MPA),an active metabolite of MMF,was observed in the study.HUVEC were treated with TNF-? or/and MPA for 24 hours.The lymphocyte-endothelium adhesion was detected by Rose Bengal staining.After treated with TNF-?,rIFN-?,and LPS,HUVEC CD40L expression was detected.HUVEC was treated with any of the modulators or each combined with MPA,respectively for 24 hours and different doses of MPA combined with LPS were also designed to stimulate HUVEC for 24 hours.The expression of CD40L on HUVEC was detected by cell-ELISA method.Results:MPA inhibited adhesion to lymphocytes of the HUVECs of either resting or stimulated with TNF-?.The cytokines used in the study induced expression of CD40L on HUVECs.MPA did not inhibit CD40L expression on resitng HUVECs,whereas it inhitbited CD40L expression induced by TNF-?,rIFN-?,or LPS,and the inhibition of CD40L expression on the cells induced by LPS was shown in dose of MMF-dependnet pattern.Conclusion:Endothelial cells express a low level of constitutive CD40L that is increased by treated with simple cytokines.MMF inhibits interactions between endothelial cells and lymphocytes by suppressing the expression of CD4OL on endothelial cells.

External-beam radiotherapy is one of the principle treatment options for localized prostate cancer. Conventionally fractionated radiotherapy is widely used in clinical practice. Studies have shown that prostate cancer is highly sensitive to hypofractionated radiotherapy, also known as stereotactic body radiotherapy (SBRT), and increasing radiotherapy dose can significantly improve the local control rate of tumor. A number of recently completed researches have shown that SBRT is as effective as conventionally fractionated radiotherapy. In terms of radiation toxicity, the short-term toxicity of SBRT is more obvious than that of conventionally fractionated radiotherapy, but there is no significant difference in long-term toxicity. SBRT can provide more convenience for patients, and the medical cost is lower, so it has a great clinical application prospect.

There are still two outstanding problems in comprehensive quality assessment index system of clinical medical undergraduates:contents of assessment is incomprehensive and every index has no quantitative research based weight.This article elaborated on a complete index framework,covering required knowledge,abilities,attitude,morality of clinical medical undergraduates and proposed a set of methods and processes,including literature research method,system analysis method,brainstorming,expert interviews,Delphi method,and some statistical methods,providing a theoretical basis for the development of comprehensive quality assessment index system for clinical medical undergraduates.