Alzheimer's disease (AD) is a most common neurodegenerative disease. The mechanisms underlying AD, especially late-onset AD, remain elusive. In the past few years, results from genome-wide association studies (GWAS) and systems approaches indicated that innate immune responses mediated by microglia played critical roles in AD. Functional analysis on animal models also showed that immune receptors or proteins expressed in microglia mediated Abeta-induced inflammation, or Abeta phagocytosis by microglia. Microglia plays double sword roles in AD. More work is warranted to elucidate the exact roles of microglia in AD, which will facilitate our better understanding of the mechanisms underlying AD.

Shou Shi Yi Bao was a journal of traditional Chinese medicine (TCM) during the period from 1935 to 1937, and was originated by Chen Huan-yun, a TCM physician in Suzhou. It is mainly to transmit the knowledge of TCM and to promote the epidemic prevention capacity of local public. The editorial characteristics and historical value of the journal were explored in initial background, staff writers, editorial policies, contents and the Editor Chen's medical ideas. Shou Shi Yi Bao was supported by many famous TCM physicians, although the journal was originated from the civil society. It was an academic TCM journal with perfect practicability for orientating to the public and highlighting the academic spirit. Chen Huan-yun was a resolute defender of TCM, and had many opinions on clinical practice and lots of scientific suggestions on TCM development. Shou Shi Yi Bao reflected the main characteristics of TCM journals in 1930s. The journal was one of the important documents to study the TCM history during the period of the Republic of China in Jiangsu Province, and it also set a stage for the struggle between TCM and Western medicine at that time. The documentary information of the journal has literature and history values in reflecting the historical process of TCM self-improvement. The success of the journal was due to not only the broken-up sectarian bias and cooperation of the TCM practitioners but also the preponderant geographic and cultural circumstances of Suzhou as well as Chen Huan-yun's profound knowledge in traditional Chinese culture and medicine.

Lymph node metastasis is the main prognostic factor of endometrial cancer patients.As the metastasis of early endometrial cancer patients is very low,it remains a controversy whether these patients are necessary to undergo conventional lymphadenectomy and a challenge to confirm the scope of lymph node dissection.We intend to demonstrate the application of lymphadenectomy in patients with early endometrial cancer via the impact of lymphadenectomy on the prognosis of these patients.The risk factors for lymph node metastasis of endometrial cancers were analyzed to explore its value in the surgical option.Furthermore,the guidance of sentinel lymph node in surgical staging and prognostic prediction of early endometrial cancer was explored to clarify the applied condition and scope of lymphadenectomy in these patients.

The ischemic heart disease has been endangering human health seriously. Although there are many kinds of anti-ischemic drugs, most of them are lacking in tissue specificity, which together with a remarkably reduced blood circulation in the ischemic zone often lead to a quite low drug distribution in the targets. Myocardial ischemia can cause a lot of pathophysiological changes, such as the enhanced permeability of the endothelial cell membrane, the up-regulated expression of various cell adhesion molecules on endothelium, the exposure of intracellular antigenic components, the decrease of pH within the ischemic zone, and so on. To date, some of these changes have been exploited with limited success to gain the passive, active and physicochemical targeting of diagnostic or therapeutic drugs to myocardial ischemic regions. However, more effective delivery strategies are still eagerly needed. Here, we reviewed and discussed the potential targeting-delivery mechanisms and strategies, used or may be used in the future, for myocardial ischemic regions.

Objective To explore the effect of atorvastatin combined with aspirin on therapeutic efficacy of acute cerebral infarction, and on the changes in neurologic impairment, blood lipids and carotid plaque, et al. Methods The 80 patients with acute cerebral infarction were randomly divided into the treatment group (n=40) and the control group (n = 40)who took atorvastatin combined with aspirin and aspirin alone respectively. The defect degree of nerve function, curative effect, changes of blood lipids and cervical vascular ultrasound parameters were compared between the two groups, and they were followed up for 6 months to observe the recurrence of cerebral infarction.Results Compared with the control group, the levels of TG, TC, HDL-C and LDL-C, internal diameter of common carotid artery, size of plaque, drag index, pulsatility index and neurological function deficit scale (NFDS) were significantly lower in treatment group [(1.36 ± 0.33) mmol/L vs.(1.77±0.80) mmol/L, (5.21±0.32) mmol/L vs. (5.80±0.37) mmol/L, (1.20±0.10) mmol/L vs. (1.43±0.16) mmol/L, (1.31±0.37) mmol/L vs. (1.57±0.39) mmol/L, (6.43±0.71) mm vs. (6.67±0.47) mm, (40.39±8.94) mm3 vs. (54.26±8.25) mm3, (0.70±0.06) vs. (0.82±0.08), (2.12±0.37) vs. (2.18±0.54), (10.24±3.31) scores vs. (14.69±3.23) scores, all P＜0.05 or ＜0.01]. The intima-media thickness and peak systolic velocity of carotid artery were higher in treatment group than in control group [(1.66±0.50) mm vs. (1.50±0.68) mm, (71.34±15.01)an/s vs. (68.97 ± 18.21 ) an/s, both P＜ 0.01]. The total effective rate was higher in treatment group than in control group (92.5% vs. 75.0%, P＜0.05), and there were no recurrence of cerebral infarction within 6 months. Conclusions Atorvastatin combined with aspirin in treatment of acute cerebral infarction is beneficial to resume neurological function, improve prognosis, decrease the volume of carotid atherosclerotic plaque, stabilize plaque and reduce blood lipids, and it play an positive action in the intervention of cerebral infarction recurrence, and it can be used to treatment acute cerebral infarction as combination therapy.

Purpose:To investigate the therapeutic effect of PEFC chemotherapy regimen (cisplatin or carboplatin,etoposide,fluorouracil and cyclophosphamide) on primary carcinoma of fallopian tube.Methods:41 patients with primary carcinoma of fallopian tube were divided into two groups: 20 patients in PEFC group received PEFC chemotherapy; 21 patients in CAP group received CAP chemotherapy. The therapeutic effects of the two groups were compared.Results:1 , 3 , 5 year progression free survival rate of PEFC group and CAP group were: 100%, 67.34%, 67.34%; 76 19%, 51 88%, 45 40% respectively ( P

In recent years, radiofrequency-ablation with minimal invasive effect has been increasingly used in the treatment of lung cancer, outcoming with obvious achievement. Great progress has been made in the experimental research including creation of electrode needle, the radiofrequency technique and clinical applications. This article overviews the experimental research, clinical application, current status and future research directions of this new treatment modality.

Objective Pulmonary sequestration (PS) is a rare disease,and its clinical symptoms are usually related to subsequent pulmonary infections.We analyzed the clinical characteristics of PS complicated by aspergillosis,and reviewed related literature,so as to disclose the association between these two diseases.Methods Sixty-nine patients with surgery-confirmed PS in Peking Union Medical College Hospital between January 1990 and December 2013 were retrospectively analyzed,including seven cases complicated by aspergillosis.Clinical manifestation,imaging and surgery of these patients were analyzed.Literature focusing on PS complicated by aspergillosis in pubmed data base was reviewed.Results In these seven patients,four cases were male,and three cases were female.Age at diagnosis ranged from 29 to 58 years old.The interval from onset to definite diagnosis ranged from two weeks to 20 years.Clinical symptoms included productive cough in seven cases,hemoptysis in three cases,chest pain in two cases,and fever in one case.All cases were intralobar PS with four in the left lower lobe and three in the right lower lobe.Consolidation in chest CT was noted in six cases.Cavitation was positive in three cases.Surgery of lung lobe resection was performed in all patients.Aberrant arteries were found during operation with the origin from aortic artery in four cases,phrenic artery in two cases,and intercostal artery in one case.Aspergillosis was diagnosed by pathology in six cases and by lung tissue culture in one case.Conclusions PS complicated by aspergillosis is extremely rare,but the trend of an increase in recent years has been noted.Strict and cautious examinations for microorganisms and pathology will help find relatively insidious aspergillosis.

Narcolepsy is a rare sleep-wake rhythm disorder in clinic practice, mainly characterized by recu-rrent unstoppable sleep during the day and often accompanied by cataplexy, sleep paralysis and hypnagogic hallucinations.Clinicians′ insufficient knowledge about narcolepsy is one of the main causes of misdiagnosis and delayed diagnosis.Moreover, narcolepsy may get easily confused by epilepsy because of complex and diverse types of epileptic seizures.Therefore, it is necessary to distinguish the two forms each other.When they are comorbidity, the diagnosis and treatment will be much more difficult.In this article, the clinical characteristics of narcolepsy and the causes of delayed diagnosis were analyzed, differential diagnosis between narcolepsy and epilepsy was investigated, and practical expe-rience in diagnosis and treatment of comorbidities were summarized, so as to raise clinicians′ awareness of narcolepsy and its comorbidity with epilepsy and improve patients′ prognosis and their quality of life.