1. Effect of Trifolium pratense isoflavones on osteoporosis rats induced by estrogen deficiency
Chinese Pharmaceutical Journal 2012;47(24):2000-2003
OBJECTIVE: To examine the effects of Trifolium pratense isoflavones (TPIF), the main active component of Trifolium pratense L., on ovariectomy-induced osteoporosis in rats. METHODS: A total of 60 six-month-old female rats were randomly assigned to a sham-operated group and five ovariectomized(OVX) groups, ie, OVX with vehicle(10 mL · kg-1 · d-1, ig), OVX with graded doses of TPIF(30, 60, and 90 mg · kg-1 · d-1, ig), and OVX with nilestriol(2.5 mg · kg-1 · week-1, ig). The animals were sacrificed after 12-week treatment. RESULTS: Compared to the OVX group, TPIF significantly inhibited the increase of body weight. In addition, TPIF administration significantly decreased serum levels of alkaline phosphatase (ALP) and tartrate-resistant acid phosphatase (TRAP), and increased serum level of estrogen. CONCLUSION: TPIF may be a potential alternative medicine for the prevention and treatment of postmenopausal osteoporosis. Its mechanism may be related to increasing estrogen level, inhibiting bone resorption, and promoting bone formation.
2.Changes of Plasma Pulmonary Surfactant Protein-A and Serum Ferritin in Neonates with Mechanical Ventilation
xiao-ni, ZHANG ; min, JIN ; chao, CHEN
Journal of Applied Clinical Pediatrics 1986;0(02):-
Objective To observe the changes of plasma pulmonary surfactant protein-A (SP-A) and serum ferritin (SF) in neonates with mechanical ventilation and its clinical significance in ventilation-induced lung injury (VILI).Methods The study was carried out in 36 neonates with mechanical ventilation and 31 neonates without mechanical ventilation .Plasma SP-A and SF levels in venous blood were mea- sured on 1,24,48,72 hours after mechanical ventilation and 24 hours after mechanical ventilation removal by Western-dot blot and radioimmunoassay (RIA).Plasma SP-A and SF levels of non-mechanical ventilation group were determined at the same time.Results Plasma SP-A levels in neonates on 24,48,72 hours after mechanical ventilation were significantly higher than those of non-mechanical ventilation group[( 2.20? 0.22)vs(1.97?0.29) ?g/L,(2.43?0.28)vs(1.94?0.33) ?g/L,(2.61?0.38)vs(1.80?0.34) ?g/L,respectively P
3.Preliminary Research on Quality Control of PACS Image Display Device
Min ZHOU ; Minming ZHANG ; Wenbo XIAO
Journal of Practical Radiology 2001;0(09):-
Objective To study the quality assurance(QA) and quality control(QC) of PACS image display device in the department of radiology equipped with PACS and radiology information system (RIS). Methods Routine maintenance and periodic calibration were performed using photometer and automatic calibration software according to American Association of Physicists in Medicine Task Group 18 (AAPM TG18) test patterns and evaluating criterion. Digital image and communication in medicine (DICOM) gray scale standard display function (GSDF) standard calibration ,maximum luminance and minimum luminance,luminance uniformity,display resolution and geometry distortion adjustment were performed quarterly on BARCO CRT displays. Results All the results were well conformed to the criteria recommended by the AAPM TG18. About 95 percents of radiological images were interpreted on the PACS diagnostic image display.Conclusion The QC program of PACS image display device is an essential to ensure high-quality in digital medical environment.
4.Changes of error-related brain activity in generalized anxiety disorder patients
Min ZHANG ; Jijun WANG ; Zeping XIAO
Chinese Journal of Behavioral Medicine and Brain Science 2010;19(9):781-783
Objective To explore the traits of error-related negativity (ERN) in generalized anxiety disorder (GAD) patients. Methods Thirty GAD patients and thirty normal controls were enrolled in this study. Use the Hamilton Anxiety Scale and State-Trait Anxiety Inventory to assess the severity of symptoms. Error-related negativity was elicited by the modified Eriksen Flanker task, recorded by Brain Products' EEG/ERP recording system,and the EEG signals were analyzed off line by Brain Analyzer software. Results There were no significant differences between two groups at age, gender composition, handedness and education (P > 0.05 ), the scores of HAMA, SAI and TAI were significantly higher in GAD group than NC group( t = 8.225, P < 0.001; t = 4.093, P <0.001; t = 6.742, P < 0.001 ) ,there were no significant difference in behavioral reactions between two groups (P >0.05) except for non-response rate(GAD:(15.29 ± 18.18)% ,NC:(7.23 ±7.99)%; t=2.184, P=0.035).The ERN amplitudes of GAD group were larger than these of NC group( FCz: GAD: ( -8.76 ±5.74) μV,NC:( -6.91 ± 3.07 )μV, F = 6.924, P = 0.012), yet the ERN latency did not show any significant group difference.There were no significant correlations between HAMA scores and ERN amplitudes/latencies. Conclusion The increased amplitudes of ERN possibly reflect the abnormally activated internal error monitoring process in GAD patients.
6.Practice of Optimizing Outpatient Service Process Using the Integrated Outpatient Self-service Platform
Xiaojuan JIANG ; Min ZHANG ; Dewen XIAO
Journal of Medical Informatics 2015;(7):24-28
The paper conducts a case study of Yangzhou No.1 People′s Hospital, introduces the practice of outpatient process opti-mization based on informatization support platform, analyzes the operation status of self-service outpatient service platform and existing problems.Based on the M/M/s model in queuing theory, the queuing model of payment for outpatient service in the hospital is construc-ted, the characteristics of queuing payment problems for outpatient service are revealed, the relationship between the sharing rate of self-service terminals and the average length of the queue in service windows, the average waiting time of patients.
7.Influence of Nimodipine on [Ca~(2+)]i Levels in Red Blood Cell in Newborn Infants with Hypoxic-Ischemic Encephalopathy and Its Clinical Significance
min, JIN ; xiao-ni, ZHANG ; chao, CHEN
Journal of Applied Clinical Pediatrics 1986;0(02):-
Objective To explore change of RBC[Ca2+]i levels in neonates with hypoxic-ischemic encephalopathy(HIE)and the influence of nimodipine on RBC[Ca2+]i and its clinical significance.Methods Fifty-eight neonates with moderate and severe HIE were randomly divided into 2 groups including routine treatment group(n=28)and nimodipine group(n=30),and 20 healthy full-term neonates were selected as healthy control group.Based on the routine treatment,nimodipine[2 mg,0.5-1.0 ?g/(kg?min)] was given intravenously in the nimodipine group for 7-10 days.Blood samples were collected before and after treatment for 72 hours and 10-14 days,respectively.The levels of RBC[Ca2+]i were measured by Fura-2 pentakis(acetoxymethyl)ester[Fura-2/AM].The results were analyzed by SPSS 10.0 software.Results 1.The levels of RBC[Ca2+]i in neonates with HIE were significantly higher than those in healthy control group[(2.83?0.36)mmol/L vs(2.15?0.18)mmol/L,P
8.Effect of Anti-Epileplic Drugs on Immunological Function
min, ZHANG ; xiao-chuan, WANG ; yi, WANG
Journal of Applied Clinical Pediatrics 2004;0(09):-
Epilepsy is a common nervous system disease,with a morbidity of 4.8‰-11.2‰,so there has been about 50 million patients globally.Drug treatment is a major mean to treat epileptic patients.Recently,researches illustrated that cellular immunity disorder and humoral immunity disorder were coexist in epleptic patients,but there was no consensus on whether it was induced by anti-epileptic drugs(AEDs) or epilepsy itself up to now.This article is aimed to explain the impact of AEDs on immunity through review recent literature internal and abroad.
9.Effect of Metarhiziun taii polysaccharide on serum glucose and immune function of diabetic mellitus model mics
Daimin XIAO ; Jianhui XIAO ; Yu CAO ; Zhimin ZHANG ; Min LIU
Chinese Journal of Immunology 2016;32(9):1338-1341
Objective:To investigate the effects of Metarhiziun taii polysaccharide on the immunity activity of the diabetic mellitus model mouse.Methods:To build stables type Ⅰ diabetic model mouse by intraperitoneal injecting small dose streptozotocin ( STZ) continuously.Then observeing weight changes,detecting empty stomach serum glucose,immune organ index( include spleen and thymus),peritoneal macrophage phagocyte ability,spleen lymphocyte multiplication and immunoglobulin IgG′s and complement C3,C4 content in blood serum of the diabetic rats.Results:The weight of model mouse had been improved by Metarhiziun taii polysaccharide, serum glucose had been improved degrade of the ability of model mouse.T,B lymphocyte proliferation had been increased obviously by middle and high dose polysaccharid,spleen index,IgG′s and C3,C4 content in blood serum of the diabetic rats could be improved by high dose distinctively.Thymus index and the capacity of peritoneal macrophage phagocyte would enhanced by middle and high dose polysaccharide inject.Conclusion:The immune function and serum glucose of typeⅠdiabetic mode rats could be improved by intra-gastriced Metarhiziun taii polysaccharide.
10.The risk factors of prehypertension and the relationship between blood pressure and atherosclerosis
Yan ZHANG ; Xin XIAO ; Yalan MIN ; Ling TU ; Cuntai ZHANG
Journal of Chinese Physician 2013;(4):437-440
Objective To explore the risk factors of prehypertension and the relationship between blood pressure and atherosclerosis.Methods The data of 456 cases in the Department of General Medicine were cross-sectional analyzed,including 174 subjects with normotension and 282 with prehypertension.The information was consisted of demographic characteristics,blood pressure,blood biochemical metabolism index,brachia-ankle pulse wave velocity (baPWV),ankle-brachial index (ABI) and carotid intima media thickness (CIMT).Results Compared to normotension group,the levels of systolic pressure,diastolic pressure,pulse pressure,body mass index,fasting blood glucose,glycosylated hemoglobin,triglyceride,uric acid,and C-reactive protein in prehypertension group were significantly increased (P < 0.05) ; and high-density lipoprotein cholesterol was significantly decreased (P <0.05) ; the body mass index(OR =1.185),triglyceride(OR =1.302),and fasting blood sugar (OR =1.690) were the independent risk factors of prehypertension ; baPWV and CIMT in prehypertension group were higher,but ABI and artery atheromatous plaque rate were not obvious changed.When baPWV or CIMT were set as the dependent variables,multiple linear regression analysis showed that systolic blood pressure(β =0.226,P =0.007),fasting blood glucose(β =0.209,P =0.018),and age(β =0.279,P =0.002) were risk factors of baPWV;systolic blood pressure(β =0.118,P =0.015),body mass index(β =0.109,P =0.001),and age(β =0.396,P =0.001) were risk factors of CIMT.Conclusions Body mass index,triglycerides,and fasting blood sugar were the independent risk factors of prehypertension.The early subclinical damage of hardening of the arteries was occurred in the prehypertension cases,and systolic blood pressure was closely related with baPWV or CIMT.