Objective To discuss the significance and effect of tuberculosis of thoracic-lumbar vertebra treated by interfixation with Z-plate in anterior approach. Methods Summarize was made in 32 cases of patient with tuberculosis of thoracic-lumbar vertebra from January 2000 to June 2004 ,All were treated by focus eliminate through anterior approach in first intention, autobody bone transplantation inter vertebra and interfixation with Z-plate in anterior approach. Results Followed up for a average of 25 months. 32 cases with tuberculosis of vertebra were cure, whole transplantation bones were bone fusion ,the fusion time was a average of 5 months. rectification angle of back protruding was 17.50,no surgery complication of hemothorax,pheumothorax, aggravation of paraplegia, leak of cerebrospinal fluid,looseness of interfixation and rupture . Conclusion Treatment of tuberculosis of thoracic-lumbar vertebra by focus eliminate through anterior approach in first intention, fixation by bone transplantation and interfixation of Z-plate have importance significance and marked effect.

Objective To investigate the expression and significance of transforming growth factor-β1 (TGF-β1) gene in bone marrow mesenchymal stem cell (BMMSC) derived from patients with multiple myeloma (MM).Methods BMMSC of 7 MM patients and 10 patients with iron deficiency anemia were cultured in vitro.The morphology of BMMSC was observed and the growth curve was portrayed according to the daily results of BMMSC proliferation.Total RNA was extracted from BMMSCs and transcription of TGF-β1 gene in BMMSC was measured by reverse transcription-PCR.Results The proliferative activity of BMMSC was not significantly different between the two groups,but expression of TGF-β1 gene of BMMSC was higher in MM patients (0.01241±0.00419) than the control group (0.00122±0.00030) (t =3.218,P ＜ 0.05).Conclusion The abnormally high expression of TGF-β31 gene in BMMSCs could contribute to the pathogenesis of MM.

Objective To investigate family caregivers' burden and fatigue condition of home-living patients with Parkinson's disease and to explore the relationship between the burden of care and the condition of fatigue. Methods By convenience sampling methods, 136 family caregivers, who took care of Parkinson's disease patients, were investigated. Caregiver burden scale and fatigue self rating scale were used to investigate the burden and fatigue status of primary caregivers of patients with Parkinson's disease. Results The total score of home caregiver's burden was (37. 54 ± 8. 15) and the total score of fatigue was (53. 18 ± 11. 62). The total score of the care burden was positively correlated with the total score of fatigue of primary caregivers of home Parkinson patients (P<0. 05); personal burden and physical fatigue, mental fatigue, fatigue total score was positively correlated (P<0. 05);the burden of responsibility and the decrease in the dynamics, mental fatigue was positively correlated (P<0. 05). Conclusions The burden of family caregivers of home-living patients with Parkinson's disease is moderate, and the fatigue condition is in the moderate level of fatigue. Nurses should strengthen the evaluation of the family caregivers' burden of home-living patients with Parkinson's disease, in order to relieve their fatigue status.

Objective:To explored the feasibility and efficacy of a rapid ramp-up,2-week maximum regimen of venetoclax(VEN)plus low-dose cytarabine(LDAC)for treating relapsed/refractory acute myeloid leukemia(R/R AML).Methods:We retrospectively analyzed patients with venetoclax-na?ve R/R AML treated with VEN+LDAC between October 2018 and November 2023.On the first day,patients received 200 mg of VEN,and the dose was quickly increased to 400 mg for the rest of the treatment;cytarabine was administered subcutaneously at a low dose of 20 mg/m2/day.The treatment duration was 10 or 14 days,depending on the condition of bone marrow hyperplasia determined on the 8th day of treatment.No patients received venetoclax monotherapy.All patients responding to salvage therapy received VEN+LDAC until disease progression or transplantation.Results:Among the patients,the median follow-up duration was 27.5 months.No clinical mani-festations of tumor lysis syndrome(TLS)occurred during the treatment.The overall response rate(ORR)was 68.75%,including four com-plete responses(CR),one complete remission with incomplete hematologic recovery(CRi),and six partial responses(PR).The median num-ber of best treatment result cycles was one cycle.The median overall survival(OS)in the whole cohort was 5.8(0.5-47.2)months;the medi-an progression-free survival(PFS)was 22.2(7.3-42.9)months.The major adverse events were grade 3-4 hematologic adverse events and in-fections.Conclusions:The 8th-day myelosuppression-adjusted VEN+LDAC regimen is a feasible salvage option with a reasonable safety pro-file in patients with venetoclax-na?ve R/R AML.Most patients tolerated the 14-day treatment;the response was generally rapid in the re-sponding patients.

Splenic lymphoma with villous lymphocytes (SLVL) or splenic marginal zone lymphoma with circulating villous lymphocytes is rare, and prolymphocytic transformation of SLVL is rarer. At present, only one case of SLVL with t(8;14)(q24;q32) translocation has been reported. In this study, we report a case of B-lymphoproliferative disorder with villous lymphocytes harboring t(8;14)(q24;q32) chromosome translocation that we inclined to SLVL with a prolymphocytic transformation. A 73-year-old female showed marked hepatosplenomegaly and high lymphocytosis (lymphocytes > 200 × 10/L). The abnormal lymphocytes had short coarse villi and round nuclei with prominent nucleoli. The immunophenotypes showed CD19, CD20, HLA-DR, CD22, CD5, Kappa, CD25, CD71, Lambda, CD7, CD10, CD23, CD34, CD33, CD13, CD14, CD117, CD64, CD103, and CD11c. The karyotype showed complex abnormality: 46XX,+ 3,-10, t(8;14)(q24; q32)[11]/46XX[9]. The cytoplasmic projection, immunological characteristics, and trisomy 3 chromosome abnormality supported the diagnosis of SLVL. However, the presence of prominent nucleoli and high lymphocytosis suggested prolymphocytic transformation, probably as a result of t(8,14) chromosome translocation. In this report, we described an unusual case of B-lymphoproliferative disorder with villous lymphocytes harboring t(8;14)(q24;q32) translocation, which could provide help in the diagnosis and differential diagnosis of B-lymphocytic proliferative diseases.
Aged ; B-Lymphocytes ; pathology ; Female ; Humans ; Immunophenotyping ; Lymphoproliferative Disorders ; genetics ; pathology ; Translocation, Genetic