Objective To assess the effects of intraventricular conduction abnormality on left ventricular function in dilated cardiomyopathy. Methods The study composed of 3 groups,16 patients of dilated cardiomyopathy (DCM) without wide QRS complexes, 16 patients of DCM with complete left bundle branch block(CLBBB),and 16 age-matched healthy individuals,all showing sinus rhythm and being complicated with mitral regurgitation. Pre-ejection contraction time(PET), left ventricular ejection time(LVET), left ventricular filling time(LVFT), myocardial performance index(MPI), mitral regurgitation time(MRT), stroke volume(SV) were recorded with pulsed or continuous-wave Doppler. Pulse tissue Doppler imagining(TDI) was performed to measure the time dispersity of electromechanical motion of left ventricular in systole and diastole on the atrial-ventricular annulus with mapping techniques. Results Time dispersity of electromechanical motion of adjacent left ventricular segments in systole[((77.9)?(13.6))ms vs ((52.1)?(13.2))ms vs ((28.3)?(7.2))ms, P

Objective To evaluate the effectiveness and safety of TCM treatment to children with mycoplasma pneumonia. Methods RCTs of trational Chinese medicine in treating children with mycoplasma pneumonia were retrieved. CNKI, Wanfang Database and CBMdisc were searched for Chinese literature, and PubMed, EMbase and Cochrane Library were searched for foreign literature. All searching time was up to May 25, 2012. Data were picked up by two system reviewers individually and evaluation standard of Cochrane was used to evaluate the quality of selected literature. Results A total of 64 RCTs including 6289 cases of children with mycoplasma pneumonia were analyzed. In the improvement of clinical symptoms, among comparison between traditional Chinese medicine and western medicine (RR=1.10, 95%CI:-1.0--1.18) and comparison between traditional Chinese medicine plus western medicine and western medicine (RR=1.14, 95%CI:1.10-1.18), curative effects of treatment group were superior to the control group, P<0.00;For the fever clearance time, among comparison between traditional Chinese medicine and western medicine (RR=-4.26, 95%CI:-8.15--0.37), comparison between traditional Chinese medicine plus western medicine and western medicine (RR=-0.97, 95%CI:-1.27--0.66), curative effects of treatment group were superior to the western medicine group. For the time of the disappearance of cough and pulmonary rales, and the basic X-ray absorption time, curative effects of treatment group were also superior to the control group. Untoward effects in western medicine group were obvious than that of traditional Chinese medicine group. Conclusion TCM could improve and shorten the duration of symptoms of children with mycoplasma pneumonia. However, it is still necessary to be verified with more multi-center, double-blind, large sample randomized controlled trials, since the literature which have been brought into related researches were with low quality.

OBJECTIVE: To develope a reversed-phase high performance liquid chromatographic(RP-HPLC) method for the determination of allitridum in human serum.METHODS: The serum sample was injected after being deproteinized with trichloroaceticacid and being extracted with hexane.A Phenomenex C1s was used as the stationary phase and the solution being composed of acetonitrile- 1%HAc(62: 38,V/V)as the mobile phase with a flow rate of 1.2 ml/min .The serum samples were monitored at 240nm.RESULTS: The peak area of allitridum against allitridum concentration was linear with a correlation coefficient of 0.9 977 over the range of 0.29～12.4 μg/ml, the limitation of detection was 0.18 μg/ml.The average recovery was (99.2 ± 6.6) %, within - day RSD＜ 5.5% (n = 5), between - day RSD＜ 5.8% (n = 5) .CONCLUSIONS: This method is rapid, accurate and sensitive,it is very suitable for the investigation on clinical pharmacokinetics of allitridum.

[Objective]To explore the value of magnetic resonance imaging (MRI) for articular cartilage lesions after bone bruise of distal femur under arthroscopy.[Method]Articular cartilage lesions of 29 cases of distal femur bruises diagnosed by MRI were examined under arthroscopy,12 cases of them combined with medial and lateral meniscus injury,17 combined with anterior cruiciate ligament rupture.[Result]The distal femur articular cartilage lesions examined under arthroscopy were corresponding to MRI findings.The lesions showed by arthroscopy were in direct proportion to MRI.These lesions were classified into Ⅰ-Ⅳ degrees.[Conclusion]Arthroscopic examination showed correspondent result to MRI findings for articular cartilage lesions.Sometimes MRI couldn't deliver the severity of cartilage lesions because of instrument factors.Arthroscopy is considered as the golden standard of evaluation for articular cartilage lesions after bone bruises.

20?10 9/L on day 16 (range 9~35).Over grade Ⅱ acute GVHD occurred in three patients(25%) and chronic GVHD occurred in five patients, including three patients with localized chronic GVHD and two with extensive chronic GVHD . The incidence of acute GVHD in allo-PBSCT is similar to allo-BMT, while care should be taken for the occurrence of chronic GVHD.

To analyze the outcome of allogeneic peripheral blood stem cell transplantation(allo PBSCT) for hematological malignancies and prevention of complications, forty one patients with hematological malignancies were treated with allo PBSCT. One regimen of prophylaxis for acute graft versus host disease(GVHD) was the combination of cyclosporine(CsA)and methotrexate(MTX),another mycophenolate mofetil(MMF) with cyclosporine and methotrexate .The results showed that all patients were successfully engrafted .The incidence of over grade Ⅱ acute GVHD after HLA matched transplantation was 21 05%(8/38). Chronic GVHD occurred in 19/25(76%) patients. Three of thirty four patients with acute leukemia(CR 1 ) and CML(CP) after HLA matched transplantation relapsed(8 82%). The disease free survival was 71 43%(10/14) after follow up for more than 2 years. The results suggest that the incidence of acute GVHD in allo PBSCT appears to be similar to allo BMT, but the incidence of chronic GVHD in allo PBSCT is higher than that in allo BMT. Infection and interstitial pneumonitis are the main cause of death.

OBJECTIVE: To investigate the characteristics and regularity of adverse drug reactions (ADR) occurred in our hospital. METHODS: 286 ADR cases collected from our hospital from Jan. 2007 to Jun. 2009 were analyzed statistically. RESULTS: There were 3 severe ADR cases. 213 ADR cases were caused by anti-infection agents in our hospital (74.48%), followed by 38 ADR cases caused by TCM preparations (13.29%). Main clinical manifestation of ADR cases were lesion of skin and its appendants in 146 cases (44.92%), followed by 62 cases of lesion of digestive system (19.08%). 202 ADR cases were caused by intravenous administration (70.63%). CONCLUSION: Pharmaceutical monitoring and administration system should be established and improved. Great importance should be attached to ADR monitoring to reduced the incidence of ADR in our hospital.

This study was aimed to optimize Qinshuang particle best spray granulation process conditions. The or-thogonal test method was used with grain yield and baicalin transfer rate as the inspection indexes. The main in-fluence factors of Qinshuang particle spray granulation process were investigated. The results showed that the best technological parameters are atomization pressure of 1 800 Pa, inlet temperature at 90°C - 100°C, outlet temper-ature at 50 ° C - 60 ° C , and the extract relative density of 1 . 10 ( 60 ° C ) . It was concluded that the reasonable pro-cess conditions make particles with stable quality, which provide the experimental basis for industrial production.

Objective To investigate the clinical efficacy of Pingchuan cataplasm combined with hyperthermia therapy for stable chronic obstructive pulmonary disease (COPD) with qi deficiency syndrome of both lung and spleen. Methods Sixty patients of stable COPD with TCM syndrome of qi deficiency of both lung and spleen were selected and randomized into treatment group and control group, 30 cases in each group. Based on conventional treatment, the treatment group was treated by Pingchuan cataplasm combined with hyperthermia, and the control group was given analog stick applicator without additional heat treatment. After 6 weeks of treatment, the TCM symptom score and the time of the first exacerbation after treatment were observed. Results Compared with the control group, Pingchuan cataplasm can reduce the patients’ TCM symptom score (F=9.843, P=0.003), and extend the interval of acute exacerbation after treatment (F=4.451, P=0.040). Conclusion Pingchuan cataplasm combined with hyperthermia applicator can improve symptoms and reduce the frequency of acute exacerbation, thus can treat and prevent the acute exacerbation of COPD.

Objective To analyse the clinical features of pelvic insufficiency fractures (PIF) in patients with cervical cancer after radiotherapy and explore the risk factors affecting its occurrence .Methods 55 cases of patients with cervical cancer that used radia-tion therapy as a single treatment were chosen in our hospital from February 2007 to May 2010 and the clinical features were ana-lysed;The fractures of spine ,sacrum ,sacroiliac joint ,ilium and pubis and femoral were observed and the density of fifth lumbar (L5 ) vertebrae ,left and right sacrum were detected via the CT or MRI (Hounsfield Unit)after 2-year follow-up ,the different factors on the incidence of PIF were explored .Results 12 cases (19 sites) of patients in 55 patients occured PIF after follow-up 2years ,the cumulative incidence was 21 .82% ;the distribution of PIF parts were followed :lumbar vertebrae had 5 cases ,sacral had 5 cases ,pu-bis had 4 cases ,sacroiliac joint had 2 cases ,iliac had 2 cases and femoral head had 1 case .The incidence rate of PIF that density of fifth lumbar vertebrae was ≤130 HU and >130 HU were 16 .36% and 5 .45% respectively ,the PIF′incidence rate that density of left side of sacrum was≤ -35 HU and > -35 HU were 18 .18% and 3 .64% respectively ,the incidence rate of PIF that density of right side of sacrum was ≤ -35 HU and > -35 HU were 20 .00% and 1 .82% respectively ,the density of the three parts all had statistical difference on the incidence of PIF (P<0 .05) .Univariate analysis showed that menopausal status and the average density of CT had statistical effects on PIF (P<0 .05);Multiple analysis showed that the average density of CT was the independent factors affecting PIF′incidence after radiotherapy .Conclusion The patients with cervical cancer may occur pelvic insufficiency fracture af-ter radiotherapy ,and its incidence is related to menopausal status and bone mineral density .