OBJECTIVE:To compare the cost-effectiveness of4antibacterials in the prevention of post-operative in-fection in patients with uterine-incision delivery(UID).METHODS:A total of1066cases with UID were ascribed to receive cefoperazone sodium/sulbactam sodium+arilin(therapy A),ampicillin sodium/sulbactam sodium+arilin(B),cefradine+ar-ilin(C)and cefoperazone sodium/sulbactam sodium(D),respectively for the prevention of infection.The cost-effectiveness of the4groups was analyzed retrospectively.RESULTS:The costs of the4schemes were4954.13yuan,4752.77yuan,3870.16yuan and3988.22yuan,respectively;The effective rates were98.5%,87.4%,84.6%and96.8%,respectively;The cost-effectiveness ratios were50.30,54.38,45.75and41.20,respectively;The incremental cost-effectiveness ratios of scheme A,B and D were77.98,315.22and9.68,respectively as against scheme C.CONCLUSIONS:Scheme D is more economical and reasonable in the prevention of post-operative infection in patients with UID.