Twenty-three patients with pain from osteoporotic vertebral fractures,aged 65-90 yr,weighing 51-78 kg,received an image intensifier-assisted nerve-root block with a 6-8 ml mixture of 0.5 ％ lidocaine,mecobalamine 0.5 mg and betamethasone sodium phosphate injection 5.26 mg in a prone or lateral position.The VAS scores before operation,at 0,1 week,1 and 3 months after operation were 8.6 ± 0.9,1.5 ± 0.7,2.8 ± 0.9,1.6 ± 0.5 and 2.5 ± 0.7,respectively.VAS scores were significantly lower at each time pint after operation than before operation (P ＜ 0.05).According to modified MacNab standard,the effectiveness of treatment was rated as excellent/good in 87％ of the patients.No complication such as bleeding,hematoma,infection,pneumothorax,hemopneumothorax,headache was found during or after operation.Selective nerve-root block is effective in the treatment of pain resulting from osteoporotic vertebral fractures in patients.

Objective To investigate the real experiences of nurses participating in the treatment of patients with new respiratory infectious diseases. Method The semi-structural interview method was used to carry out in-depth interviews with 8 nurses who were involved in the whole process of treatments and cares of patients with SARS and H1N1 influenza to understand their real experiences. Result The nurses, who participated in the treatment and care to patients with new respiratory infectious diseases, experienced such emotions of nervousness, excitement, anxiety, fear, exhaustion, obtained support from their families, hospitals, society and meanwhile recognized their lack of professional knowledge and clinical skills. Conclusion The nurses participating in the treatment of patients with new respiratory infectious diseases should be given strengthened professional training , psychological and social support.

This article reviews the concept, classification, screening and evaluation tools of cognitive frailty, and research in chronic diseases of the elderly, with the aim of improving the awareness and understanding of cognitive frailty among medical and nursing staff. It is recommended to further strengthen the research on cognitive frailty in elderly patients with chronic diseases, optimize screening tools, and promote the construction of targeted intervention programs, so as to provide a basis for the research progress of cognitive frailty in elderly chronic diseases in China.

Objective To explore the influence of acupuncture point massage combined with limb function exercise on ankle brachial index (ABI) and pulse wave velocity (PWV) in patients with coronary heart disease (CHD). Methods According to scores by grace score scale, 180 CHD patients were divided into three groups: low risk group (n=58), moderate risk group (n=68) and high risk group (n=54). Within the three groups, the patients were divided into the experiment group and the control group by using the random digital table. The control group was treated with routine nursing intervention , while the experiment groups accepted acupuncture point massage and limb function exercise training on the basis of control groups. We collected the values of ABI and PWV at four points-in-time: before intervention, 7 days after intervention, 30 days after intervention and 90 days after intervention. Results Repeated measurement data analysis of the experiment group and control group suggested that:in the moderate and high risk groups, there was statistically significant difference (P<0.05) in the data at the four time points. There was no statistically significant difference (P > 0.05) in time and group interaction effect. The difference between the experiment group and control group was statistically significant (P<0.05). Repeated measurement data analysis showed that there was no statistically significant difference (P>0.05) in ABI&PWV interaction effect at the four time points between the experiment group and control group. In the low-risk group,the differences in time points compared with the main effect were insignificant (all P>0.05). In comparison of main effect at all the four time points, there was significant different in the moderate and high risk group (P<0.05), And it suggested that time and group interaction, namely effect of time factor (1 d, 7 d, 30 d, 90 d), was not decided by the division of groups. In comparison of main effect, the difference was statistically significant (all P < 0.01) in the moderate and high-risk group, which indicated the main effect (intervention) playing main role. However, there was no statistically significant difference (P>0.05) of ABI&PWV before and 90-days after intervention. Conclusion Acupuncture point massage combined with limb function exercise can effectively improve the peripheral artery blood supply in CHD patients, lower ABI and promote PWV.

Objective:To investigate the psychological state and influencing factors of clinical front-line nurses in response to public health emergencies.Methods:We used stratified cluster random sampling method to survey 1187 front-line clinical nurses from February to March, 2020, using the Psychological Questionnaire for Emergent Events of Public Health.Results:The questionnaire survey showed that the scores for dimensions of depression, neurasthenia, fear, obsessive-anxiety and hypochondria were (0.52±0.02), (0.37±0.01), (0.87±0.02), (0.24±0.01) and (0.25±0.01), respectively. There were statistically significant differences in scores of hypochondriac dimension for clinical nurses at different hospital levels ( F=4.30, P<0.05), and there were statistically significant differences in scores of depression, neurasthenia, obsessive-anxiety and hypochondriac dimension for nurses in different nursing units ( F values were 4.34-11.11, all P<0.05). Multiple linear regression analysis showed that the nursing unit factors had influence on depression, neurasthenia, obsessive-anxiety and hypochondria. Conclusions:Clinical front-line nurses experienced negative psychology such as depression, neurasthenia and fear in public health emergencies. As a manager, it is necessary to strengthen preventive psychological counseling, do a good job in the theory, operation and protection knowledge training for public health emergencies, humanistic care, establish a good organizational atmosphere to maintain the physical and mental health of clinical nurses, and ensure the quality and safety of nursing.

Objective To explore the effects of peer support education on the compliance and quality of life in patients with liver cirrhosis complicated with upper gastrointestinal bleeding.Methods A total of 60 patients with liver cirrhosis complicated with upper gastrointestinal bleeding during January 2015 and December 2016 were selected in this study using convenient sampling. Patients who treated from January to December 2015 were included in the control group (n=30) and those treated from January to December 2016 were included in the observation group (n=30). Patients in the control group adopted routine nursing. Based on the routine nursing care, the observation group received additional peer support education. The medication adherence questionnaire and the MOS Item Short Form Health Survey (SF-36) were used to compare the compliance and quality of life before and after the intervention within two groups.Results After six months of intervention, the intervention group had significantly better compliance compared with the control group [(1.23±0.76) vs (2.23±1.45);t=3.144,P<0.05]. The scores of SF-36 (except health dimension) were significantly higher in the observation group compared with the control group (P<0.05).Conclusions Peer support education may be helpful in improving the medication compliance and quality of life in patients with liver cirrhosis complicated with upper gastrointestinal bleeding.

Objective To investigate the mechanism of white matter damage (WMD) and the neuroprotective effect of Xenon on neonates with WMD.Methods Three-day-old SD rat pups (n =96) were randomly divided into the blank control group (n =24),the WMD control group (n =24),the Xenon intervention group A (n =24) and the Xenon intervention group B (n =24) by random number method according to their birth time.WMD rat models were successfully established by giving intraperitoneal injection of lipopolysaccharide(LPS) 0.05 mg/kg combined with carotid artery ligation and hypoxia for 1 hour in the WMD control group and the Xenon intervention groups.In the control group,only 9 g/L saline (0.05 mg/kg) was injected intraperitoneally,while carotid artery ligation and hypoxia were not administered.Rats in Xenon intervention group A and group B were given inhalation of 500 mL/L Xenon for 3 hours at 0 and 2 hours respectively after establishment of the models.Six rats in each group were randomly selected and decapitated at 0,24,48 and 72 hours after the intervention.The brain white matter on the right was analyzed by using HE staining and myelin basic protein(MBP) immunofluorescence staining,and real-time quantitative polymerase chain reaction was used to detect the expressions level of CLIC4 mRNA.Results (1) Brain tissue pathology:compared with the blank control group,the brain white matter on the right of the WMD control group and the Xenon intervention group A and group B had loose and disordered structure,nuclear pyknosis and cytoplasm loosening.However,the lesions in both Xenon intervention group A and group B were significantly less than those in the WMD control group,and there was no significant difference between the Xenon intervention group A and group B.(2) MBP measurement:the number of MBP-positive cells in the brain white matter on the right of WMD control group was significantly lower than that in the blank control group,while compared with WMD control group,they were significantly higher in Xenon intervention group A and group B.(3) CLIC4 mRNA expression level:compared with blank control group,the expressions levels of CLIC4 mRNA at most time point were higher both in the WMD control group and the Xenon intervention group A and group B (all P ＜ 0.05),except the time point 24 h in the Xenon intervention group A.The expressions of CLIC4 mRNA in group A and group B were significantly decreased compared with those in the WMD control group (all P ＜ 0.05).However,there were no significant differences between Xenon intervention group A and group B (P ＞ 0.05).Conclusions The expressions of CLIC4 mRNA in brain tissues on neonatal rats with WMD significantly increased,indicating that the mitochondrial pathway could be one of the pathological processes of WMD.Early Xenon intervention may reduce neonatal WMD by reducing the expression of CLIC4 mRNA,which plays a neuroprotective role.

Objective To investigate the risk factors of falls and balance force in community elderly patients with orthostatic hypotension,so as to prevent from fall risk.Methods The elderly fall risks assessment tool and the elderly balance force test table were investigated in community elderly patients with orthostatic hypotension in community.Results The average score in fall risk assessment of 189 elderly patients with orthostatic hypotension in community was (6.78±5.49)and the average score in balance ability was(5.42±5.23), and there were statistically significant differences in occupation, gender and marital status(P<0.05).The fall risk assessment was positively correlated with the balance ability(r=0.637,P< 0.01).Conclusions The elderly patients with orthostatic hypotension in community have a higher risk of falls and balance problems, so the community should carry out comprehensive measures to improve the environment of community and home, strengthen the balance ability training,and reduce the risk of falls.

Objective To explore the real experience of patients with hepatic failure during artificial liver treatment.Methods Totally 10 patients with hepatic failure undergoing artificial liver treatment hospitalized in Department of Liver Disease of Nantong the Third Hospital of Nantong University from January to June 2016 were selected as the research objects by objective sampling method. Semi-structured interview method was used to conduct the deep interview and know the real experience of patients.Results Four themes were extracted by interviewing the real experience of patients with hepatic failure during artificial liver treatment, which were: comfortable change, anxiety, fear, lack of effective coping capacity and lack of knowledge.Conclusions Patients with hepatic failure suffer great physical and mental pains during artificial liver treatment. Nursing staff should take positive measures to relieve patients' discomforts and negative moods, improve patients' coping capacity and promote their quality of life.

Objective To understand the medication compliance,family care and their correlation in patients with chronic hepatitis B. Methods From January to Decemeber 2016,two hundred and seventy-six chronic hepatitis B patients from a class III grade A infectious disease hospital in Nantong were selected as the research object by convenient sampling method. They were investigated by the medication compliance questionnaire and the family care index questionnaire. Results Chronic hepatitis B patients with good medication compliance accounted for 48.91%,the family care score was(7.82±2.38)points. Pearson correlation analysis showed negative correlation between the medication compliance of patients and family care(r=-0.173, P < 0.05). There were significance differences in medication compliance among different age,gender, occupation,cultural level,monthly income,medical payment(χ2=27.45,8.42,13.36,24.76,10.65,18.38;P < 0.05). There were significant differences in family care scores among patients of different age,gender, occupation,marital status,monthly income and method of medical payment(t=7.41,2.52,4.96,6.88,5.65, 11.26;P<0.05). Conclusions The medication compliance and family care of chronic hepatitis B patients still needs to be further improved. It is necessary to strengthen the multi family-oriented nursing intervention,and improve medication compliance and family care so as to delay progression and improve quality of life of patients.