The vascular endothelial cells (VECs) are not only a mechanical barrier of blood cycle cells and vascular smooth muscle cells, but also largest and most important type of endocrine organs.Because of its mechanical barrier action It is highly susceptible to in vitro and in vivo a variety of physical and chemical factors in the injury; damaged VECsvascular endothelial cells, especially the disordered endocrine function, the inevitable imbalance to a variety of active substances secreted or related active substances, finally result in dysfunction of cardiovascular system.This article reviews many mechanisms underlying VECsvascular endothelial cell injury, investigates VECsvascular endothelial cell repair mechanisms, and study ways to protect and repair the injured VECsvascular endothelial cells, and improve the prognosis of vascular disease.

The special environmental features of high altitude, such as hypobaric hypoxia, low temperature, arid, high solar radiation, variable climate and geochemical anomaly, cause great effects on human physiology and health. It will provide valuable references and new ideas to study drug's metabolism in special environment of high altitude hypoxia, and give the guidance to clinical reasonable medication, avoiding adverse reactions and personalized medicine in plateau areas. This article reviewed the effect of high altitude hypoxia on drug metabolism, elaborated metabolic characteristics of some drugs and the activity and expression of drug metabolism enzymes under hypoxia environment at high altitude, and discussed related mechanism.

This paper reviewed the research of functional electrical stimulation (FES) in China, including mainland, Taiwan and Hong Kong, based on the literature. Specially, the research and development on FES system and device was discussed.

Objective To explore the clinical curative effect of AF system combined vertebra re-duction and posterolateral bone fusion treatment thoracolumbar burst fracture .Methods Seventeen pa-tients with thoracolumbar burst fracture using period stage , according to the system of AF clinical symptoms and image data line pressure decreased , and the pressure or not to hurt inside the vertebral pedicle autoge-nous bone grafts are grain filling and vertebral posterolateral line between the axon , lamina around small joints and bone , and postoperative follow-up X-ray inspection regularly , observe internal fixation and verte-bral vertebral height and adjacent intervertebral space changes , or after fixation and reset lost .Results following up 13 months, vertebral body height restore and maintain good , bolt looseness and broken and ver-tebral body height complications such as lost were no found in 17 cases.Conclusion Treatments of Poste-rior fixation combined short stage AF vertebral body and posterolateral bone fusion on thoracolumbar burst fracture are not only rebuild the vertebral height , but also make the vertebral obtained after three pillars in stable, reduce the internal fixation and compressed vertebral again such complications .

Objective To present and evaluate the diagnosis and treatment of congenital giant megaureter. Methods From 1992 to 1999, 6 cases of congenital giant megaureter were diagnosis and treated, the pathogenesis, diagnosis and treatment of congenital giant megaureter were discussed. Results Resection of the kidney and ureter were carried out in all the 6 with satisfaction. Conclusions The diagnosis may be confirmed on B ultrasonography, CT, or intravenous urography. Nephroureterectomy is the principal method of treatment for congenital giant megaureter.

Objective To summarize the experience on diagnosis and treatment of ectopic ureters. Methods 52 patients with ectopic ureter were analysed retrospectively. Results Of the 52 patients,sonography,IVU,CT and retrograde ureterography were used in 37,45,8 and 18 patients respectively.49(94.0%) cases got the diagnosis preoperatively by these methods.28(53.8%) patients underwent ureteral reimplantation,12(23.0%)nephrectomy,9(17.3%) upper pole partial nephrectomy and 1(1.9%) with ureterocele incised endoscopically.The 42 patients have been followed up for 6 months to 10 years with an average of 3 years. Conclusions Most of the cases can be diagnosed preoperatively by utilizing the appropriate methods.Ureterovesicle reimplantation,upper pole partial nephrectomy and nephrectomy are the effective modalities in the treatment of ectopic ureters.

[Objective]To investigate the surgical feasibility and efficiency with microendoscopy discectomy technique for the recurrent lumbar disc herniation.[Method]Ninteen cases underwent disc excision with different operative approaches,11 cases had undergone previous surgery with MED,7 cases with conventional approach,2 cases removing whole vertebrate plate approach,3 cases removing half vertebrate plate approach,2 cases with minor vertebrate plate window approach.There were 13 cases of ipsilateral protrusion and 2 cases of contralateral protrusion,3 cases of adjacent segment protrusion.All of these cases were revisioned by MED except for 1 case.[Result]Eighteen cases were finished by MED technique successfully except for 1 case which was changed to open operating.All cases were followed up from 6 months to 2.5 years,averaged 1.5 years.Postoperative JOA score was improved from preoperative average (9.61?3.40)? to average (26.17?2.60) ?,the rate of improvement final was 86.32%.In terms of Macnab scoring system,the satisfactory rate was 88.89%.[Conclusion]MED technique is an effective method for recurrent lumbar herniation,but the operator needs lots of experience in minimal invasive spine surgery.

HIFU treatment allows the destruction of a precise volume of tissue within an tumour without harming surrounding structures.The FEP-BY02 model is one of commercially available machines based on this technique,which is proved effectively in clinical practice.It's basic architecture,functional principle and some suggestions for safety use are introduced in this paper.

Objective To explore the relationship between learning and memory ability and antioxidant enzyme (SOD, CAT, GSH-Px)activities in specific brain areas of D-galactose model rats. Methods The aging models were induced by D-galactose in 3-month old rats, and the learning and memory ability of aging model was detected in model MG-2 maze. The activity of SOD, CAT and GSH-Px in brain cortex, cerebellum,hippocampus, striatum and hypothalamus were detected immediately after rats were executed. Results The learning and memory ability of D-ga-lactose aging model was lower than that of control group. The difference of antioxidant enzyme activity among different rat brain areas was significant. The correct response rate of D-galactose aging model was( 58.9 ± 5.4 ) %, which is significantly lower than that of the control group (66.8 ±8.9) %, P ＜ 0.05. The times of response required reaching the standard after 24h of aging model rats was significantly higher than that of the control( Aging group :29.5 ± 12.8, Control group 16.6 ± 6.2; P＜ 0.01 ). Correct response rate after 24h was significantly lower than that of the control ( Aging group :67.3 ± 10.3 , Control group: 79.1 ± 6.9; P＜ 0.01 ). The SOD activity in cortex, hippocampus and striatum( Aging group :66.12 ±5.89,80.46 ± 6.57,87.82 ± 6.87; Control group :57.63 ± 4.21,67.46 ± 6.80,68.37 ± 6.52) significantly reduced ( P ＜ 0.05 and P ＜ 0.01 ).The CAT activity in cortex, hippocampus, striatum and hypothalamus( Aging group :6.45 ± 0.55,5.86 ±0.35,6.93 ± 0.63,8.89 ± 0.38; Control group :5.32 ± 0.56,4.76 ± 0.38,4.37 ± 043,6.11 ± 0.37) significantly reduced ( P ＜ 0.05 and P ＜ 0.01 ). GSH-Px activity was similar in each brain area without significance ( P ＞ 0.05 ). Conclusions The learning and memory ability of aging mode rats decreased. The change of antioxidant enzyme activities in hippocampus, cortex, striatum and hypothalamus is closely related to learning and memory ability.

OBJECTIVE:To prepare rufloxacin eye drops METHODS:The content of rufloxacin was determined with HPLC method The therapeutic effect of the eye drops was observed in 150 out-patients with severe ocular infections RESULTS:Determined by HPLC method,the average recovery of rufloxacin was 100 12%(RSD=1 18%) After treatment,130 patients recovered,16 improved and had no efficiency with a total effective rate of 97 33% CONCLUSION:The eye drops have definite therapeutic effect The HPLC method is simple,rapid and accurate in determination of the content and no special reagent is needed