The vascular endothelial cells (VECs) are not only a mechanical barrier of blood cycle cells and vascular smooth muscle cells, but also largest and most important type of endocrine organs.Because of its mechanical barrier action It is highly susceptible to in vitro and in vivo a variety of physical and chemical factors in the injury; damaged VECsvascular endothelial cells, especially the disordered endocrine function, the inevitable imbalance to a variety of active substances secreted or related active substances, finally result in dysfunction of cardiovascular system.This article reviews many mechanisms underlying VECsvascular endothelial cell injury, investigates VECsvascular endothelial cell repair mechanisms, and study ways to protect and repair the injured VECsvascular endothelial cells, and improve the prognosis of vascular disease.

Objects:To investigate the current situation of interpersonal communication inpreparatory students in one Xinjiang medical college from the exchanges between students.Methods:Using self-developed questionnaire,a survey was conducted among 200 preparatory students and depth interviews were conducted for typical cases.Results:Preppies showed a strong willing of interpersonal communication.In the process of students' interaction,some features were presented as followings:pure motives but dissimilarity,narrow range of interactions,lack of interaction ability and the single form of social activities.Conclusion:Based on the above current situation of interpersonal communication in preparatory students,it should enhance the language application ability of preparatory stage,change the idea and attach importance to the education of humanistic quality in preparatory education and train preppy's expression and listening art.

Objective To discuss the etiology,clinical findings,anatomical characters,diagnosis and treatment of the painful flexion deformity of the hallux after open reduction and internal fixation of the fibular fractures.Methods From October 1996 to March 2004,we treated 33 cases with flexion deformity of the hallux after fibular fracture,including 19 males,14 females,with a mean age of 33.2 years old(ranged from 22 to 49 years).24 cases were ankle fractures,according to Lauge-Hansen clssification,pronation-external rotation for 18 cases;supination-exteral rotation for 4 cases;pronation-eversion for 2 cases.9 cases were distal third tibial and fibular fractures.19 cases were simple hallux flexion deformity,8 cases were combined with the second and third toes deformity,6 cases were combined with not only the second and third toes but also the fourth and fifth toes deformity.The deformities were corrected by flexor hallucis longus tendolysis or lengthening alone or flexor digitorum longus lengthening in combination.Results 19 cases were simple hallux flexion deformity,the deformities were corrected simply by flexor hallucis longus tendolysis(7 cases)and lengthening(12 cases).14 cases were combined with the lesser toes deformity,the flexor hallucis longus tendon were lengthened alone in 6 cases,and both the flexor hallucis longus and the flexor digitorum longus were lengthened in 8 cases.During an average duration of follow-up of 6 months(2 to 10 months),there were no postoperative complications.All patients had full correction of all deformed toes and reported relief from pain,ease of shoe-fitting and subjective improvement of gait.There was no recurrence of the deformity.Conclusion Adhesions of the flexor hallucis longus tendon to the fibular fracture site should be considered when a flexion deformity of the hallux occurs after open reduction and internal fixation of the fibular fractures.Variations in the interconnections between flexor hallucis longus and flexor digitorum longus in the region of the knot of Henry also have special clinical significance.

Objective To determine bone mineral density (BMD) and biochemical parameters of bone metabolism in premenopausal female patients with systemic lupus erythematosus(SLE), and investigate the correlation between them. Methods Lumbar and femoral BMD in 30 female patients with SLE was determined by dual energy X ray absorptiometry. In 30 female patients and 39 controls, the corrected serum levels of calcium, phosphorus, alkaline phosphatase, creatinine and albumin were measured by routine methods, and bone specific isoform of alkaline phophatase, propeptide of type 1 procollagen, deoxypyridinoline excretion, telopeptide of type 1 collagen, osteocalcin, parathyroid hormone, 25-OH vitamin D, testosterone, progesterone, estradiol, follicle stimulating hormone and luteinotropic hormone were measured by ELISA or RIA. Results According to the WHO criteria, 39% patients with SLE had normal BMD, 46% had osteopenia and 15% had osteoporosis at the lumbar spine; at the femoral neck 38.5% had normal BMD, 38.5% had osteopenia and 23% suffered form osteoporosis. All other bone resorption and formation markers measured were not significantly different except significantly higher corrected serum levels of albumin calcium (P=0.0001)and significantly lower osteocalcin level and phosphorus value(P=0.03,P=0.002) were found in the SLE patients. Of all sex hormones tested lower testosterone and higher follicle stimulating hormone concentration were seen in patients with SLE(P=0.001,P=0.42). Conclusion A high incidence of osteopenia and osteoporosis was found in premenopausal patients with SLE, which seems to be attributable, at least in part , to decreased bone formation in SLE patients.

目的观察功能锻炼对神经根型颈椎病恢复期的作用和效果。方法患者随机分为试验组49例和对照组48例。试验组采用体育保健学的锻炼方法结合常规手法整复,对照组只采用与试验组相同的手法整复。结果两组间基线资料无显著性差异(P>0.05)。试验组的总有效率为89.8%,对照组的总有效率为56.3%(P<0.01),试验组治疗前后症状积分明显优于对照组(P<0.01)。结论主动锻炼有助于改善神经根型颈椎病疗效。

Objective To observe the effect of Weici acupuncture on shoulder-hand syndrome after acute stroke.Methods 90 cases were divided into two groups:the test group(49 cases) who were treated with Weici(a kind of acupuncture) and the control group(41 cases) who were treated with the normal acupuncture.Results The total effective ratio of the test group was 93.88%,and that of the control group was 73.17%(χ2=7.2863,P<0.01).Conclusion Weici acupuncture is more affective on shoulder-hand syndrome after acute stroke than the normal acupuncture.

ObjectiveTo observe the effects of the Partner Rehabilitation Gymnastics on periarthritis of shoulder in later stage. MethodsPatients were randomly divided into 2 groups: 60 in treatment group accepted the Partner Rehabilitation Gymnastics, and the other 60 accepted the forcing active and passive physiotherapy.Results76.66% of the treatment group recovered, 96.66% improved; while 45% of the control group recovered, 73.33% improved. The scores of visual analogous scale and activity of daily living improved after treatment in both groups, and the differences pre- and post-treatment were more in treatment group than in control group. ConclusionThe Partner Rehabilitation Gymnastics is more effective than the routine forcing active and passive physiotherapy on periarthritis of shoulder.

[Objective]To discuss the fractures classification,operative route,internal fixation and operative therapeutic effection of acetabular fractures.[Method]Thirty-four cases of acetabulum fractures and femoral head dislocation were involved from November 2001 to August 2006 in our hospital throught operative treatment.The classification according of AO system:type A fractures 24 cases,type B 10 cases.Applicated Kocher-Langenbeck operative route was applied in 20 cases,Gibson route 2cases,illioinguinal route 4 cases and anteriorcombined posterior route 4 cases.Thirty-two cases were adopted reconstruction plates and screws and 2 cases steel-wire cerclage to fix fracture.All patients were followed up.[Result]Acorrding to evaluation system of AAOS:excellent in 12 cases,good in 12 cases,fair in 4 cases,poor in 6 cases.Total exellence rate were 71%.[Conclusion]Combinate full-scale imageology information,correct classification of fracture according of AO,reasonable surgical approach and fixation,correct subtle technique during the operation and effective fracture resetting are keys to improve the effect of acetabular fractures.

Objective To analyze the clinical profiles of lupus mesenteric vasculitis (LMV).Methods Thirty-six SLE patients diagnosed with LMV and 72 SLE patients (1:2) without LMV at West China Hospital between October 2009 and January 2012 were enrolled.The imaging,clinical manifestation,laboratory examinations data were analyzed retrospectively.Quantitative differences were analyzed by the Student's t and Z tests and qualitative data were compared with Chi-square.P value less than 0.05 was considered as statistically significant.Results ① The prevalence of LMV in patients with SLE was 1.2％(36/3 051),while 47％(17/36) as the initial symptom of SLE.Thirty-six LMV patients were all female.The prevalence of abdominal pain was 78％(28/36),nausea or vomitting was 58％(21/36),abdominal distension was 50％(18/36),diarrhea was 47.2％ (17/36),intestinal perforation was 3％ (1/36) and incomplete obstruction was 8％ (3/36).Enhanced CT scan showed 81％(25/31) patients suffered from intestinal dilation and (or) mesenteric edema;SLEDAI (17±5),C3 (0.44±0.25) g/L,C4 (0.10±0.09) g/L,Z value on above items were 4.30,-3.85 and-2.94 respectively compared to SLE patients without LMV,and all P＜0.05,the differemces were significant.In addition,Also,the proportion of ANA and anti-ENA antibody showed no significant difference.68.6％(13/36) patients were also diagnosed with lupus nephritis;61％(22/36) patients were treated with methylprednisolone more than 200 mg/d resulting in relief of symptom.Conclusion Female patients with SLE may be more likely to suffer from LMV;Enhanced abdominal CT scan is still essential to the diagnosis of LMV.LMV is correlated with urinary system malfunction.LMV always occurs in active lupus with low C3 and C4 level.More than half patients should be treated with corticosteroid and cyclophosphamide pulse therapy.

BACKGROUND:Vascular endothelial growth factor(VEGF)can promote vascular endothelial regeneration,inhibit thrombosis,and attenuate neonatal intimal thickness and luminal stenosis degree.OBJECTIVE:The present study established atherosclerosis models in rabbits and observed the effects of local transfection of VEGF gene on restenosis after angioplasty.DESIGN,TIME AND SETTING:A randomized controlled animal experiment was performed at the Laboratory of Microorganism,Tongji Medical College,Huazhong University of Science and Technology between November 2004 and December 2006.MATERIALS:Rabbits were daily raised with high-fat diet to create atherosclerosis models.Twenty successful rabbit models were randomly and evenly divided into a control group and a gene treatment group.METHODS:The DcNDA 3.0 recombinant human VEGF165(hVEGF 165)was trimsferred to the ventral aorta through the use of Foley's catheters.and the pcDNA3.0 was transfefred in the controls.MAIN OUTCOME MEASURES:At 1,2,and 4 weeks after surgery,luminal area of left renal artery opening was measured by MRI.At 2 and 4 weeks after surgery,the ratio for intimal to medial area was obtained through the use of HMIAS-2000 high definition color medical image analysis software.Simultaneously,vascular endothelial cell regeneration was observed by immunohistochemistry of factor Ⅷ related antigen.RESULTS:The pcDNA3.0/hVEGF 165 could be successfully transferred through the use of Foley's catheters.At 2 and 4 weeks after surgery,luminal area was larger in the gene treatment group than in the control group(P<0.01);simultaneously, the ratio of intimal to medial area was significantly smaller in the gene treatment group than in the control group(P<0.05).In the gene treatment group,expanded vascular endothelial cell regeneration was accomplished at 2 weeks after surgery,while in the control group,it took 4 weeks.CONCLUSION:pcDNA3.0/hVEGF 165 gene transduction can promote local vascular endotllelialization and apparently attenuate restenosis degree and intiaml thickening.