AIM To develop an HPLC method for the simultaneous content determination of ginsenosides Rb1,Rd,F4,Rg1,20 (R)-Rg3,20 (S)-Rg3,Rgs,20 (R)-Rh1,20 (S)-Rh1,Rh4,Rk1,Rk3 and notoginsenoside R1 in Shusanqi Powder (processed Notoginseng Radix et Rhizoma).METHODS The analysis of 70％ methanol extract of this drug was performed on a 35 ℃ thermostatic Agilent Zorabax-C1s column (4.6 mm ×250 mm,5 μm),with the mobile phase comprising of acetonitrile-water flowing at 1.0 mL/min in a gradient elution manner,and the detection wavelength was set at 203 nm.RESULTS Thirteen saponins showed good linear relationships within their own ranges (r =0.999 5),whose average recoveries were 90.01％-108.32％ with the RSDs of 0.62％-3.54％.CONCLUSION This sensitive and accurate method can be used for the quality control of Shusanqi Powder.

Objective:This article is to study the quality of life and the situation of social support for the elderly in Weifang while analyzing the correlation between them.Methods:This study was undertaken among elderly aged over 60 followning the European five D health scale and Social Support Rating Scale.The results were analyzed statistically.Results:On the living quality of elderly in Weifang,the EQ-SD index was (0.78 ±0.12) and the EQ -VAS index was (76.42 ± 14.67).The result from each scale shows a tremendous health issue among the elderly in Weifang.On the other hand,the situation of social support for the elderly in Weifang appeared optimistic.Still,this situation can be improved in practical supports.Also,there was significant negative correlation between EQ-5D and SSRS (r =0.260,P ＜ 0.05).Results of multiple linear regression show that the subjective support and objective support may enter the regression equation.Conclusion:To conclude,the city of Weifang awaits improvements in aged care and social support for the elderly.Only by this chance the quahty of life of the elderly may be improved.

Objective To study the effects of poly lacticoglycolic acid(PLGA) ultrasound contrast agent on tumor lymph node imaging and its mechanism.Methods PLGA ultrasound contrast agent was made by double emulsion method; VX2 tumor cells were harvested from carrier rabbits and inoculated in the thigh of healthy New Zealand White rabbits. Implants were allowed to grow for 14 to 18 days before imaging. Popliteal lymph nodes were imaged as the injection sites were massaged. And macrophages were used to investigate the mechanism for lymph node enhancement. Results PLGA ultrasound contrast agent had a tight size distribution. Tumor lymph node was significantly enhanced by PLGA ultrasound contrast agent. Macrophages experiment showed that macrophages could phagocyte lots of PLGA ultrasound contrast agents.Conclusions PLGA ultrasound contrast agent is good for lymph node imaging. The possible mechanism for lymph node enhancement is that macrophages in lymph node can phagocyte lots of PLGA contrast agents, which causes the concentration of PLGA contrast agent in lymph node.