Objective To investigate the changes of serum electrolytes and blood coagulation function in the operative patients after massive blood transfusion.Methods Serum electrolytes and coagulation function during and after blood transfusion were de-tected and analyzed in 25 cases of massive blood transfusion.Results After intraoperative transfusion of blood products 1000mL, there were no significant changes in PT,APTT,TT and K+ ,Na+ ,Cl- ,Ca2 + (P >0.05),but after transfusing more than 3 000 mL of blood products,PT,APTT and TT were significantly prolonged(P <0.01),at the same time,the level of FIB was decreased ob-viously,K+ and Ca2 + were decreased obviously(P <0.01 ).Conclusion The patients with massive blood transfusion are prone to appear low potassium,hypocalcemia and coagulation function disorder.So the various indexes should be dynamically monitored dur-ing operation for avoiding the occurrence of serious complications.