Objective To study the anticoagulation therapy of lower molecular weight heparin in the treatment of patients with acute pancreatitis.Methods Seventy-three patients with acute pancreatitis were divided into anticoagulation group(n=38)and control group(n=35).The serological indexes and prognosis of patients were detected.Results Anticoagulation treatment with lower molecular weight heparin significantly decreased the white blood cell count,increased the oxygen partial pressure in arterial blood,shoaened the duration of hospitalization,and reduced the aggravation rate,secondary operation rate and mortality of patients with acute pancreatitis.Conclusions Anticoagulation treatment with lower molecular weight heparin is safe,effective and can improve the prognosis of patients with acute pancreatitis.

OBJECTIVE: To test the association of K469E, the common intercellular adhesion molecule-1 (ICAM-1) polymorphism with chronic obstructive pulmonary disease (COPD) and expression of ICAM-1 in Han people of Central and South Region in China. METHODS: A case-control study was done on 91 patients with COPD and 80 matched controls of Han people from central and south region in China, mainly from Hunan Province. Genomic DNA was extracted from white blood cells. ICAM-1 sequences were amplified by PCRand analyzed by agarose gel electrophoresis. Genotypes were defined by base sequencing. In addition, soluable intercellular adhesion molecule-1 (sICAM-1) serum levels were measured in 86 people picked out randomly from the COPD group and the control group. RESULTS: There was no difference in the frequency of the genotype and allele between the COPD group and the controls, but compared with those who were not very severe, the frequency of KE/ EE genotypes and E allele in COPD patients at very severe stage was significantly higher (10/16 vs 26/75, 12/30 vs 20/150, P<0.05). The level of sICAM-1 increased in the COPD patients, with negative correlation to forced expiratory volume in one second for the percentage of predicted value (FEV1%). But in both COPD patients and controls, the level of sICAM-1 did not differ significantly in different genotypes(P>0.05). CONCLUSION K469E polymorphism of ICAM-1 may not affect the susceptibility of COPD and the expression of ICAM-1 in Han people from central and south of China in this study, but carriers of E allele are at high risk of developing severe stage of COPD.
Aged ; Alleles ; Base Sequence ; Case-Control Studies ; China ; ethnology ; Female ; Genotype ; Humans ; Intercellular Adhesion Molecule-1 ; genetics ; Male ; Middle Aged ; Molecular Sequence Data ; Polymorphism, Genetic ; Prognosis ; Pulmonary Disease, Chronic Obstructive ; genetics ; Risk Factors

Liver metastasis is one of the main causes of death in patients with colorectal cancer. About 15%-25% of patients with colorectal cancer have synchronous liver metastasis at the initial diagnosis. With the development of new evidence and concept of surgery, there is a improvement in the understanding of the surgical treatment, transformation treatment, criteria of surgical resectability and prognosis of patients with colorectal liver metastasis (CRLM). Based on latest progress, specialized multi-disciplinary team decides the best individualized treatment strategy. This paper reviews the current situation and progress of CRLM.

Liver metastasis is one of the main causes of death in patients with colorectal cancer. About 15%-25% of patients with colorectal cancer have synchronous liver metastasis at the initial diagnosis. With the development of new evidence and concept of surgery, there is a improvement in the understanding of the surgical treatment, transformation treatment, criteria of surgical resectability and prognosis of patients with colorectal liver metastasis (CRLM). Based on latest progress, specialized multi-disciplinary team decides the best individualized treatment strategy. This paper reviews the current situation and progress of CRLM.

Objective:To explore the effect of partial splenectomy with minimally invasive surgical technique in treating splenic benign lesions.Methods:The clinical data of 19 patients, who underwent partial splenectomy with laparoscopic and robotic surgery for benign lesions of spleen, in Faculty of Hepato-Pancreato-Biliary Surgery, Chinese PLA General Hospital from January 2021 to January 2023 were retrospectively analyzed. There were 11 males and 8 females, with the age of (29.2±10.1) years old. Clinical data, such as gender, age, operating procedure, intraoperative blood loss, operation time, postoperative hospital stay and postoperative complications, were collected.Results:Nineteen patients successfully underwent partial splenectomy with minimally invasive surgery, including laparoscopic partial splenectomy (13 cases) and robotic partial splenectomy (6 cases). Irregular partial splenectomy was performed in 10 patients, and regular partial splenectomy in 9 patients. There was no conversion to open surgery. Operation time, intraoperative blood loss, postoperative hospital stay and time of postoperative drainage tube indwelling were 178(130, 200) min, 200(50, 300) ml, 6 (4, 7) d and 3(2, 5) d. Postoperative complications developed in 4 cases (21.1%, 4/19), including left pleural effusion (3 cases) and spleen remnant infarction (1 case).Conclusion:Partial splenectomy by minimally invasive surgery in treating splenic benign lesions is safe and feasible.