Objective: to explore the influence of traffic accident psychologically and physiologically Method:120 inpatients fractured in traffic accident (study group) and 67 fractured inpatients (control group) from other reasons were collected The study group was divided into those with stable character (with N score of EPQ56) All subjects completed SCL-90 Their IL-1?, IL-2, IL-8 and cortisol level were measured Result: The total score and subscores of SCL-90 of study group were significantly higher than that of control The serum levels of IL-1?, IL-2, IL-8 were lower than that of control, while cortisol level was higher than control The interleukin levels of stable group were higher than that of unstable group Conclusion:Patients injured by traffic accident have poor health both mentally and physically, especially for those with unstable character