[Objective]To evaluate curative effects of Osteoset~ synthetic bone transplants and internel fixations on calcaneus fracture.[Method]Twenty-three patients with calcaneus fracture,who were treated by Osteoset~ synthetic bone transplants and internel fixation,were followed up by plain X-Rays and JOA functional questionnaires.Fracture patterns were based on Sanders methods.[Result]A series of 23 patients,7 of which were sanders Ⅱ,15 were sanders Ⅲ,3 were sanders Ⅳ,were treated with ORIF and Osteoset~ implants.The preoperative Blher's angle was 4.8 degrees(standard deviation 6.6 degrees).Blher's angle increased to a mean of 26.8 degrees(SD 8.6 degrees) postoperatively.In the first 3 months after surgery,a mean decrease in the Blher's angle of 0.4 degrees(SD 2.27 degrees) occurred.One month after surgery osteoset synthetic bone transplants,which was replaced by new bone,were gradually absorbed and degraded.JOA questionnaires suggested that the whole effective rate was 92 percent.[Conclusion]Osteoset synthetic bone transplants and internel fixations has good therapeutic effects on patients with comminuted calcaneus fracture.Osteoset~ synthetic bone has the same effects as autogenous bone.

Objective To perform modification study of cyanoacrylate (CA) medical adhesive and to select the optimal mo-difying material and the best ratio.Methods Carboxylic multi-walled carbon nanotubes (MWCNTs-COOH), multi-walled carbon nanotubes (MWCNTs), hydrophobic nano-silica, nitrile rubber, epoxy resin and polymethyl methacrylate (PMMA) were used to modify 5% triclosan/cyanoacrylate antimicrobial adhesive respectively. The bond strength, toughness and viscosity of the modified adhesive were examined in different concentrations.Results 0.064% MWCNTs-COOH, 6% nano-silica, 4% nitrile rubber and 6.4% epoxy resin all had good effects in strength modification. The bond strength were (14.71±1.48)MPa, (14.03±1.92)MPa, (14.6±1.78)MPa and (14.05±1.46)MPa respectively. 8% nano-silica had the lowest Tg of (1.1±0.24)℃ and the strongest viscosity of (15 536.68±28.4)cP. When the nano-silica concentration was 8%, the compound was very viscous and sticky. When the antimicrobial adhesive modified with 6% nano-silica, the bond strength was (14.03±1.92)MPa, the Tg was (3.6±0.68)℃, and the viscosity was (5 278.87±31.68)cP.Conclusion 6% nano-silica is the best modifying material, and has the optimal effect of modification.

Objective To study the effect of different dose of VitC in the flap survival.Methods The Wistar rat was used as the experimental animal.On the back of each rat,a skin flap,measuring 1.5cm?6cm,caudally based,was elevated and separated wound edges and the flap bed from the flap itself by a silicone sheet.The VitC 30mg/ml,120mg/ml,300mg/ml were taken in the areas between flap and sheet respectively.With 8 rats in each group,the VitC group was as trial group,while the physiological saline group was as control group.On the seventh day after the flap elevation,flap survival length measurement would be done.Results The flap survival length changed with the dose of VitC.When the dose of VitC was 120 mg/ml,the maximum length was got.When the dose of VitC amounted to 300 mg/ml,the flap will be necrotic.Conclusion The effect of VitC on flap is bidirectional: suitable dose can improve its survival in some way;the flap will be necrotic along with the increase of the dose.The clinical side effect of VitC in whole body toxic effect is often noticed,such as renal toxicity,while the partial side effect is often ignored.The experiment shows that large local dose of VitC will result in side effect.So the dose of VitC should be controlled to reduce side effect.

A stent for bloodvessel anastomosis, with a slippery, soft out layer and a rapidly soluble inner layer, is developed in this paper. The out layer is made up of the gelatin with a high purity and a low molecular weight, and the inner one of polyglycol with a molecular weight of 20000. The structure changes of the stent surface are studied with anastomosis environment simulated. The result proves that the stent can be applied to bloodvessel anastomosis

In this paper, the solution modes of two stents with different structures are compared, and then one involved is elected as the optimum stent for anastomosis. Made of PEG20 000, two stents are solid and hollow respectively. The result proves that the hollow one, with the advantages of nonblocking bloodstream, undeflected and rapid solution, low requirement for raw materials, is fitter for anastomosis than the solid one.

Objective To design a new flap model using for study on effects of some drugs which would maximize flap survival,and to evaluate its experimental availability.Methods The Wistar rat was used as the experimental animal.On the back of each rat,a skin flap,measuring 1.5 cm ? 6 cm,caudally based,was elevated and separated.Wound edges and the flap bed were separated from the flap by a silicone sheet and the drug was put in the areas between flap and sheet.On the seventh day after the flap elevation,historical and physiological measurement to blood flow and skin specimens would be done.The repeatability of the model was calculated.Results Single pedicle separaration flap needed 26 rats as samples when the resolution was 10% in testing,while the back flap model(10 cm ? 3 cm ) needed 28 rats.The needed samples were 2 rats and 5 rats respectively when the resolution was 25%.So it was believed that with high repeatability,the model of pedicle separation flap met the basic principle of testing design and was suitable for the study of the same kind.Conclusion The model can be used with confidence to study the effects of drugs on the flap survival.

Objective To research and make one kind of sealant gel to prevent glue from leaking effectively,and protect vascular anastomosis site,raise the vascular anastomosis patency.Methods The experiment was carried out based on theory and methods in chemistry;According to the membrane performance,the membrane water solubility,and other characters,the author took experiment on the alginic acid sodium,chitsan,the gelatin and other biological materials.Results Through the experiment by membrane performance,the alginic acid sodium met the requirement,which became the membrane with the CaCl2 reaction at once.Its membrane was not dissolved in the water.And the characters of its 1%-3% solution were good on fluidity and surface contact angle determines.The biological compatibility of the compound of it with 20% CaCl2 solution was good.Conclusion The characters of the composition,which is double component sealant made from 1-3% alginic acid sodium and 20%CaCl2 solution,is best in the biological experiment.Before new medical glue appeared in clinical,this gel is hopeful to be applied in clinic and provide theory basis for clinical anastomosis.

Objective To study the effect of the VitC, bFGF, Magnesium sulfate and Papaverine in single pedicle separation flap survival. Methods The Wistar rats were used as the experimental animal. On the back of each rat, a skin flap, measuring 1.5 cm?6cm, caudally based, was elevated. Wound edges and the flap bed were separated from the flap itself by a silicone sheet. The VitC, bFGF, Magnesium sulfate and Papaverine were taken in the areas between flap and sheet. With 8 rats in each group, the drug-taken group was as trial group, while the physiological saline group was as control group. On the seventh day after the flap elevation, flap survival length was measured. Results The selected drugs could improve flap survival in some way, among which the effects of the VitC was the most distinct. Conclusion All the drugs can improve blood-flow, so it is believed the selected drugs can improve flap survival by improving flap’s blood-flow.

Objective This paper is to study a new sutureless vascular bonding method. Methods New-Zealand rabbits were randomly assigned to one experimental group and one control group. 10 end-to-end bonding on rabbit femoral arteries (1.2mm vessel) were performed using the experimental technique with histoacryl glue (OB) and a central channel soluble stent. In the control group, 10 rabbit femoral arteries (1.2mm vessel) were anastomosed with the standard suture method. The patency rates and anastomotic time were recorded. The late anastomoses were evaluated with arteriograph and stoma tissue pathological section. Results The anastomosis mean time of the experimental group is 7.91 minutes and the one of the control group is 12.90 minutes. The immediate patency rates of two groups are both 100% and the late patency rates are 80% and 90% respectively. There are no haemorrhage when the clamp released and no distortion and stricture caused by sutures. Conclusion The sutureless vascular bonding method has no needs for suture needle and line, and thus the possible injuries during suture are reduced. The stent makes the vessel free from stoma stricture and binder invasion. The stoma leakage is also avoided through the adhensive. The enhanced suture speed results from the short clotting time and the hollow structure of the stent. With all the above-mentioned excellences, the method proves simple and efficient.

Objective To evaluate the curative effects of percutaneous osteoperiosteal decortication combined with distraction osteogenesis for treatment of nonunion of lower-extremity bones.Methods A retrospective analysis was performed of the 32 patients who had been treated using osteoperiosteal decortication combined with distraction osteogenesis from September 2011 to December 2014 for nonunion of lower-extremity fractures.They were 23 males and 9 females,with a mean age of 33.4 years (range,from 15 to 62 years).After their former internal or external fixators were removed,the 2 fracture ends were fixated by a retractile mono-lateral or circular external fixator.Under radiographic monitoring,a percutaneous incision was made with a 5 mm sharp chisel,down to the bone.Scar and ossified tissue between the fracture ends were debrided and cut along the fracture line.Mter the marrow cavity was reamed,a new irregular wound was created at sclerotic fracture ends.Scale-shaped chips (1 mm thin and 5 mm in diameter) were elevated using a chisel on surface of the cortical bone within 2 cm from the fracture ends.The external fixators were adjusted to compress the fracture sites.On the 8th day after operation,the eternal fixators were applied to distract and compress at nonunion sites to stimulate the osteogenesis.Results All the patients were followed up for an average of 12.5 months (range,from 8 to 42 months).Primary union was successfully achieved in 28 patients while delayed union occurred in 3 patients who finally achieved union after adjuvant therapies like shock wave and or local injection of bone marrow blood.The average time for union was 4.6 months(range,from 4 to 7 months).The mean time for external fixation was 6.2 months (range,from 5 to 8 months).One patient encountered nonunion of lateral tibial cortical bone 6 months after surgery but eventually achieved union by autologous ilium grafting.Joint functions in all postoperative patients were similar to those before operation.Conclusion Percutaneous osteoperiosteal decortication combined with distraction osteogenesis is a simple,minimally invasive and effective treatment for nonunion of lower-extremity bones,avoiding disadvantages brought by traditional surgery,like massive trauma and excessive bleeding.