Objective To observe the effect of the soft tissues injury around atlantoaxial joint on memory abilities of mice.Methods 44 mice were divided into the model group and control group with 22 animals in each group.The soft tissues around atlantoaxial joint were injured in the model group by surgery between the first and the second cervical vertebrae.The changes of learning and memory of mice were observed with step-down avoidance test,water-maze test and hole-board test;the expression of caspase-3 in hippocampus was observed by immunohistochemical staining.Results Compared with the control group,escape latency was longer and wrong times were more in water-maze test of the model group(P<0.01). In step-down avoidance test of the model group,the reaction period prolonged and wrong times increased obviously(P<0.01).In hole-board test,the latency period prolonged and the times of extending the holes decreased significantly(P<0.01).Degenerated or dead neuron in hippocampus of surgery-treated mice was found scatteredly or continuously with HE staining,the expression of caspase-3 protein was showed positive with immunohistochemical staining.Conclusion The soft tissues injury arround atlantoaxial joint can induce abnormality of the stability of cervical vertebra,which aggravated the aging process of the mice and decreased abilities of learning and memory.

Objective To explore the effect of persistent psychological intervention on negative emotions, immune function and quality of life to patients with ovarian cancer in biotherapy period. Methods A total of 80 ovarian cancer patients were randomly divided into the control group (biotherapy and routine nursing) and the intervention group ( psychological intervention in addition to biotherapy and routine nursing). In the intervention group, Hamilton anxiety scale (HAMA) and Hamilton depression scale (HAMD), and European organization for research and treatment of cancer quality of life questionnaire-30 ( QLQ-C30) were used to measure the psychosomatic reaction, quality of life, and immune level by flow cytometry among ovarian cancer patients during biotherapy 3 weeks after and before psychological interventions. Results Three weeks after intervention, the scores of HAMD (9. 27 ± 3. 15) and HAMA (10. 17 ± 3. 06) in the intervention group were significantly lower than those in control group (16. 93 ± 10. 49) and (18. 97 ± 6. 24) (t = 1. 74,1. 78;P <0. 05), while the scores for general quality of life (71. 52 ±19. 50), the cognitive function (65. 40 ±19. 97) and emotional function (80. 97 ±15. 59) in the intervention group were higher than than these of the control group (t =2.45,2. 67,2. 58;P < 0. 05). The scores for fatigue (34. 76 ± 20. 78), insomnia (41. 75 ± 29. 19) and loss of appetite (59. 57 ± 15. 78) in the intervention group were lower than that of the control group with statistically significant differences (t = 2. 98,3. 27,2. 88;P < 0. 05). Persistent psychological intervention had no significant effect on the immune level of patients ( P > 0. 05). Conclusions Persistent psychological intervention can improve the state of negative emotions and quality of life, and has positive effects on assisting cancer biotherapy.

Objective To explore the effects of Balint group work combined with compassion meditation on psychological capital and professional burnout of nurses in tumor department. Methods A total of 60 nurses in tumor department were randomly divided into intervention group ( n =30, given Balint group work and compassion meditation once a week for 12 weeks) and control group ( n =30, no activities) from August to October 2014. All nurses were assessed with nurses psychological capital questionnaire ( PCQ-R ) and professional burnout inventory ( MBI-GS) before and after implementation of Balint group work and compassion meditation. Results The PCQ-R scores of the self-efficacy (4. 97 ± 0. 26), hope (4. 27 ± 0. 08) and resiliency (4. 72 ± 0. 43) improved obviously in the intervention group than that of control group [(3. 87 ± 0. 24),(3. 53 ± 0. 49), (3. 62 ± 0. 18)] with statistically significant differences (t=17. 03, 8. 16, 12. 92;P<005);the MBI-GS scores of the emotional burnout sense (13. 42 ± 7. 98) and depersonalization tendency (3. 75 ± 2. 19), sense of achievement (45. 76 ± 15. 78) in the intervention compared with (24. 22 ± 11. 01), (7. 54 ± 5. 57) and (37. 73 ± 21. 34) in the control group (t=4. 35, 3. 47, 2. 26;P<005). Conclusions Implementation of Balint group work with compassion meditation can improve the psychological capital and decrease the professional burnout of nurses in tumor department.

Objective To explore the effect of combined Naikan therapy and modified Morita therapy on psychological distress and post traumatic growth in elderly patients with cancer pain.Methods Ninety elderly patients with cancer pain were randomly assigned into two groups;those in the study group(n =45)were given Naikan therapy and modified Morita therapy for 4 weeks and those in the control group (n =45) were given standardized aerodyne treatment and standardized nursing care.All subjects were assessed with the Distress Thermometer and Problem Listand the Post traumatic Growth Inventory before and after Naikan therapy and modified Morita therapy.Results Compared with the control group,the study group was associated with significantly decreased scores of psychological distress(1.8± 0.1 vs.3.9 ± 0.2,t =1.78,P＜0.05),emotional problems (1.2 ± 0.4,vs.2.4±0.4,t=1.41,P＜0.05)and family problems(1.1±0.1,vs.2.9±0.1,t=1.63,P＜0.05).The study group also showed markedly higher scores in posttraumatic growth(66.0± 19.9 vs.45.3± 27.6,t=2.58,P＜0.05),relationships to others(34.8±12.1 vs.23.8±12.2,t=1.91,P＜0.05),new possibilities(25.2 ± 10.1 vs.13.7± 4.4,t=1.94,P＜0.05),personal strength(20.7 ± 10.4 vs.7.6 ± 3.1,t =2.03,P ＜ 0.05),spiritual change (11.6 ± 5.6 vs.5.4 ± 2.7,t =1.26,P ＜ 0.05),and appreciation of life(18.9±6.2 vs.6.1±-2.1,t=1.88,P＜0.05) than the control group.Conclusions Naikan therapy and modified Morita therapy can decrease psychological distress and improve post traumatic growth in elderly patients with cancer pain.