Cardiovascular Diseases ; diagnosis ; Humans ; Magnetic Resonance Imaging

Promyelocytic leukemia (PML) protein can regulate many cellular processes, Here we summarize the role of PML protein in cell and mechanisms according to researches in recent years.

Hematopoietic stem cell transplantation(HSCT) is one of the measures therapy on acute leukemia in children.Very-high-risk children with acute lymphocytic leukemia (ALL),such as Philadelphia chromosome-positive(Ph+),T cell immunophenotype,achieved the first complete remission(CR1),and then receive allogeneic HSCT(allo-HSCT).The transplantation group had significantly improved disease-free survival(DFS)and overall survival(OS) compared with chemotherapy group. ALL children in the second complete remission(CR2) were recommended to receive allo-HSCT,especially early-relapse group. All children in the third complete remission (CR3) were recommended to receive an allo-HSCT,and reduce replapse rate through inducing graft versus leukemia.Total body irradiation-based conditioning regimens in children with ALL has advantage over chemotherapy conditioning regimens.Children with acute myeloblastic leukemia (AML) achieved CR1 and then undergo all-HSCT.This group had significantly improved DFS and OS compared with chemotherapy group.The children with relapsed AML,if having suitable donor,were recommended to receive allo-HSCT. The children with AML who underwent transplantation relapse,and can receive the second transplantation.There was no advantage in children patients with AML using TBI-based conditioning regimens.Conditioning regimens consisted of high-dose cytarabine,in combination with granulocyte colony-stimulating factor has advantage,and improve DFS. Unrelated umbilical cord blood has emerged as a potential option.Compared with unrelated bone marrow transplantation,there was no different in DFS and relapse.For the extent,it is one of the donor hematopoietic stem cell sources.

Objective To discuss the mechanism of rubia cordifolia extractive affecting some biochemical indicators of blood serum and sporting ability in highly endurance-trained rats,which can provide theoretical basis for using rubia cordifolia extractive as sport supplements.Methods After establishing the highly endurance-trained rats model,we tested the exhaustion time in the trained rats and the contents of serum urea(BUN),lactic dehydrogenase(LOH),blood lactate(BLa)as well as the cruarin(Hb)in the rats.Results The activity of LDH in training group was greater than that in silent group(P

Coronary Stenosis ; etiology ; pathology ; Diagnostic Imaging ; Humans

Objective To demonstrate the manifestations on positron emission tomographycomputed tomography (PET-CT) at different stages in anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis.Methods PET-CT was performed in 10 patients with anti-NMDAR encephalitis at different clinical stages,and the images were analyzed to investigate the relation of metabolic patterns in the images with clinical presentations.Results Except for normal PET-CT images in 2 patients,images in 8 patients at early stage of the disease showed generally increased 2-[18F] fluoro-2-Deoxy-D-glucose(18F-FDG) uptake at frontal and temporal lobe,basal ganglion and cerebellum,indicating hyper-metabolism in these areas,while 2 of them also had mixture of hyper-and hypo-metabolism in parietal-occipital region.In longitudinal analysis of PET-CT images in these 8 cases,starting at basal ganglion,18 F-FDG uptake gradually decreased bilaterally,prominently at left dominant hemisphere and right cerebellum.Conclusions During the course of anti-NMDAR encephalitis,18F-FDG metabolism markedly increases at early stage and then gradually declines at late stage,at frontal,temporal,parietal and occipital lobes,basal ganglion and cerebellum,predominantly at left dominant hemisphere and right cerebellum.However,in relapsing anti-NMDAR encephalitis,18 F-FDG metabolism in brain does not show these characteristics.

BACKGROUND:The elastic modulus of the fiber post is close to that of the dentine, so it can form a homogeneous whole and share the masticatory force, which can ease the stress concentration of dentine and prevent from tooth fracture. ＜br> OBJECTIVE:To investigate the effect of alveolar bone height and fiber post length on the fracture resistance of endodontical y treated maxil ary central incisors. ＜br> METHODS:Forty-eight human maxil ary central incisors were assigned randomly to six groups (n=8) of three different post insertion depths (5, 7, 9 mm) and two alveolar bone levels (2 and 5 mm) from the cement-enamel junction. Al of them were restored by glass fiber posts with composite resin core and cast metal crown. The samples were loaded in a testing machine with a crosshead speed of 1 mm/min at a 45° angle to the long axis of the tooth on the palatal surfaces until tooth fracture occurred. The maximum load and failure mode were recorded. ＜br> RESULTS AND CONCLUSION:Alveolar bone height had a significant influence on the fracture resistance (F=560.943, P>0.05), but fiber post length did not have a significant influence on it (P>0.05). Significant differences were found between the normal and resorbed alveolar bone groups in the number of repairable fracture patterns (χ2=5.689, P＜0.05). Under the circumstance of lowered alveolar bone height, lengthening fiber post cannot enhance fracture resistance of the teeth.

BACKGROUND:The elastic modulus of the fiber post is close to that of the dentine, so they can form a homogeneous whole and share the masticatory force, which can ease the stress concentration of dentine and prevent from tooth fracture. OBJECTIVE:To observe clinical effects of anterior teeth with flared root canals restored by fiber posts using three application methods. METHODS:Anterior teeth with flared root canals from 48 patients were involved. They were divided into three groups, then restored with three post-core crowns respectively: a single fiber post, rehabilitation with composite resin, and fiber post combined with accessory post. Al patients were folowed up for 2 years to observe post and core loosening, fracture and root fracture. RESULTS AND CONCLUSION:The group of a single fiber post was failed in eight teeth including four cases of post and core loosening and four cases of post and core fracture, with a successful rate of 64%. The group of rehabilitation with composite resin was failed in three teeth including two cases of post and core loosening and one case of post and core fracture, with a successful rate of 90%. The group of fiber post combined with accessory post was failed in two teeth of post and core loosening, with a successful rate of 93%. The successful rate of the group of a single fiber post was lower than that of the groups of rehabilitation with composite resin and fiber post combined with accessory post (P < 0.05) . The difference between the groups of rehabilitation with composite resin and fiber post combined with accessory post was not statisticaly significant (P > 0.05). The clinical effects of rehabilitation with composite resin and fiber post combined with accessory post are better than that of a single fiber post. But the method of combination fiber post with accessory post is recommended because of easy operation.

Objective To compare the differences of blood glucose detected by four methods with different instruments and specimen types at early stage in severely burned rats.Methods 24 Sprague-Dawley (SD) rats were randomly divided into two groups:control group 1 (Sham scald group,n=8) and scald injury group 1 (n=16).Blood samples of scald injury group 1 were collected at 12,and 24 hours after scald (n=8,each time).Another 20 SD rats were randomly divided into two groups:control group 2 (Sham scald group,n=10) and scald injury group 2 (n=10).Blood samples of scald injury group 2 were collected at 12 hours after scald.The rats in scald injury group 1 and 2 were placed into scalding water (95.0±0.5)℃ for 15 seconds to model third-degree burn with 30％ total burn surface area (TBSA).The rats in scald injury group 1 were given intraperitoneal injection with normal saline(40 ml/kg) immediately,while those in scald injury group 2 were given intraperitoneal injection with normal saline (40 ml/kg) 6 hours after scald.The rats in Sham scald group 1 and 2 were placed into warm water 37℃ for 15 seconds,and did not received injection.Portable glucometer/caudal artery (vein) blood,portable glucometer/abdominal aorta blood,spectrophotometer/femoral venous plasma,and spectrophotometer/abdominal aorta plasma were used to detect blood glucose.Results ①Compared with Sham scald group 1,the levels of blood glucose detected by portable glucometer/caudal artery (vein) blood and spectrophotometer/femoral venous plasma in scald injury group1 at 12,24 hours after scald were significantly increased(P＜0.05).Compared with Sham scald group 2,the levels of blood glucose detected by portable glucometer/abdominal aorta blood and spectrophotometer/abdominal aorta plasma in scald injury group 2 at 12 hours after scald were significantly increased(P＜0.05).②The comparison of portable glucometer/caudal artery (vein) blood and spectrophotometer/femoral venous plasma in Sham scald group 1,portable glucometer/abdominal aorta blood and spectrophotometer/abdominal aorta plasma in Sham scald group 2 had no statistical significance (P＞0.05).The levels of blood glucose detected by portable glucometer/caudal artery (vein) blood were significantly lower than those detected by spectrophotometer/femoral venous plasma (P＜0.05) in scald injury group 1.The comparison of blood glucose detected by portable glucometer/abdominal aorta blood and spectrophotometer/abdominal aorta plasma had no statistical significance in scald injury group 2 (P＞0.05).Conclusion Four kinds of methods used in this study shows that the levels of blood glucose were significantly increased at early stage in severely burned rats,and the portable glucometer/abdominal aorta blood is a relatively simple and fast method to detect blood glucose.