Colorectal cancer is one of the most common malignant tumors. The majority of the patients die of metastases and recurrences after surgery. Circulating tumor cells (CTC) exist in the patients' peripheral blood, which can be considered as the crucial step in the metastasis cascade, thus being considered as the most valuable prognostic indicator. This paper summarized the clinical research works about CTC in eolorectal cancer during recent years.

Objective To analyze the clinical effect of membrane guided bone regeneration technique combined with 3 I implant system in anterior dental implant.Methods 50 patients with anterior teeth missing were selected as the experimental group,they received membrane guided bone regeneration technique combined with 3 I implant system of dental implant.50 cases alone with 3 I implant system of dental implant were selected as the control group.The clinical data were retrospectively analyzed.The effects of the two groups were compared.Results Statistical results showed that the satisfaction of appearance and function had significant difference between the two groups(χ2 =6.73,P<0.05).The operation area of plaque index (PLI) (t=3.16,P<0.05),gingival sulcus bleeding index (MBI) (t=6.32,P<0.05),probing depth (PD) (t=2.63,P<0.05) had significant differences between the two groups.The thickness of the buccal tongue of the bone graft,and other indicators of the top of the implant to the top of the alveolar ridge showed significant differences between the two groups (t=17.65,P<0.05,t=8.48,P<0.05). Conclusion Using membrane guided bone regeneration technique and 3 I implant system combined application can improve dental implant in the anterior and the success rate of patients on the appearance and function of satisfaction after dental implant in the anterior,and to broaden the bone defect of anterior tooth planting the indication effect,it is worthy of clinical promotion.

Objective To observe the clinical effect of combined treatment of single tooth loss and implant denture.Methods The clinical data of 80 patients with single tooth loss were analyzed retrospectively.According to the different surgical methods,they were randomly divided into control group and observation group,40 cases in each group.The control group was treated with implant denture,the observation group was treated with orthodontic treat-ment.The clinical efficacy of the two groups was observed.Results The total effective rate of the observation group was 97.50%,which was significantly higher than 62.50% of the control group(χ2 =15.31,P <0.05).The satisfac-tion scores of the observation group were higher than those of the control group,the differences were statistically signif-icant(t =12.21,17.78,15.98,11.85,9.35,all P <0.05).Conclusion The clinical effect of combined treatment of orthodontic and dental implants for patients with single tooth loss is remarkable,and can achieve good results,and improve the treatment satisfaction,it is worth promoting.

Objective To observe the effect on serum inflammatory factors and immune function of Shiwei Longdanhua particles in elderly patients with acute bronchitis.Methods 120 cases of elderly patients with acute bronchitis from November 2014 to October 2016 were selected and randomly divided into the observation group and the control group with 60 cases in each group, according the order of single and double number.The control group was given conventional treatment, and the observation group was given Shiwei Longdanhua particles based on the control group.Treatment for seven days, to observe the differences of serum inflammatory factors (hs-CRP, TNF-αand IL-6, IL-1) and immunologic function indexes (CD3 +, CD4 +, CD8 +, CD4 +/CD8 +and IgM, IgG, IgA) between the two groups.Results After treatment, hs-CRP, TNF-αand IL-6, IL-1 of the two groups decreased with before treatment, the difference was statistically significant (P<0.05), and all indexes of the observation group were lower than those of the control group, the difference was statistically significant ( P<0.05 ) .After treatment, CD3 +, CD4 +, CD4 +/CD8 + of the two groups increased with before treatment except CD8 +decreased, the difference was statistically significant (P<0.05), there was no significant difference between the control group and before treatment, there was significant difference between the two groups after treatment (P<0.05).After treatment, IgM, IgG and IgA of the two groups decreased with before treatment, the difference was statistically significant (P<0.05), and all indexes of the observation group were lower than those of the control group, with significant differences, the difference was statistically significant (P<0.05).Conclusion Shiwei Longdanhua particles has the effects of inhibiting inflammatory reaction and improving the immune status in the treatment of elderly patients with acute bronchitis .

Objective To compare the clinical efficacy of small titanium plate rigid internal fixation and intermaxillary fixation in the treatment of simple mandibular fracture,and to explore the best treatment method for the reduction of fractures of the mandible.Methods 252 cases with simple fractures of the mandible were randomly divided into the two groups.126 cases of group A were treated by rigid internal fixation,126 cases of group B were treated by intermaxillary fixation.The patients were followed up for 6 months after operation.The complications,occlusion and mouth opening were compared between the two groups.And then,the data were analyzed.Results 120 cases of group A occlusal relation recovered to normal,the appearance and function were recovered well.The average mouth opening was 3.90cm.4 cases got postoperative infection,1 case titanium plate was broken.118 patients of B group occlusal relation recovered to normal,the appearance and function were restored,no case of infection and clamp plate broken.10 cases happened bad oral health condition,gingiva swell and teeth loosen.8 cases complicated with bad occlusion.There were no statistical differences between A and B group about occlusion and(x2=0.30,0.86,all P ＞ 0.05).Conclusion Two treatment methods are effective in the treatment of simple mandibular fracture,rigid skillfully master indication to get best efficacy.

Colorectal cancer is one of the most common malignant tumors. The majority of the patients die of metastases and recurrences after surgery. Circulating tumor cells (CTC) exist in the patients’ peripheral blood, which can be considered as the crucial step in the metastasis cascade, thus being considered as the most valuable prognostic indicator. This paper summarized the clinical research works about CTC in colorectal cancer during recent years.

Bone marrow stroma provides the microenvironment for hematopoiesis and is also the source of mesenchymal stem cells. Marrow mesenchymal stem cells are capable of self-renewal and differentiation into all mesodermal cell types and neuro-ectodermal cells, such as osteoblast, chondrocyte, myoblast, T/L fibroblast, stromal cell, adipocytes, neuron, astrocytes, and so on. These abilities make the mesenchymal stem cells as an excellent target cell of tissue engineering, cell transplantation and gene therapy.

Objective:To explore the nursing efficacy of 321 health education model on maintenance hemodialysis patients with itchy skin.Methods:A total of 97 cases of maintenance hemodialysis patients with itchy skin from January 2019 to December 2019 in the Central Hospital of Panzhihua were divided into control group of 49 cases and study group of 48 cases by table of random number. The patients in control group were taken with conventional nursing and health propaganda measures while the patients in study group accepted a different nursing mode of combining 321 health education model. The Chinese version of the Four-Item Itch Questionnaire (FIIQ), the Chinese version of the Dermatology Life Quality Index (DLQI), and the Chinese version of the Kidney Disease Questionnaire (KDQ) were used to evaluate the skin itchy status and its influences to patients′ life and life quality of the 2 groups before and after intervention.Results:There was no significant difference in the skin itchy status and its influences to patients′ life and life quality before intervention between the two groups( P>0.05). After intervention, the total score of FIIQ, and the scores of the three dimensions of itchy degree, itchy frequency, and influences on sleep were respectively (7.46 ± 0.94), (1.83 ± 0.26), (1.92 ± 0.29), (1.86 ± 0.23), which were all lower than the same data of the control group patients: (12.36 ± 1.24), (2.69 ± 0.31), (3.02 ± 0.42), (2.91 ± 0.37), showing differences with statistical significance ( t values were 14.79-21.90, P<0.05). After intervention, the total score of the DLQI, and the scores of five dimensions of symptom perception, daily life, entertainment and leisure, work and study, and treatment of the patients in study group were respectively (10.55 ± 1.27), (2.85 ± 0.29), (2.11 ± 0.32), (2.47 ± 0.29), (1.72 ± 0.25), and (2.21 ± 0.27), which were all lower than the same data of patients in control group: (14.47 ± 1.78), (3.92 ± 0.37), (1.57 ± 0.22), (1.64 ± 0.25), (1.26 ± 0.18), (1.21 ± 0.11), indicating statistically significant difference ( t values were 9.67-23.80, P<0.05). After intervention, the total score of KDQ and the scores of the four dimensions of physical symptoms, fatigue, depression, and frustration of the patients in study group were respectively (121.66 ± 15.91), (27.36 ± 3.02), (24.44 ± 3.44), (26.71 ± 3.58), and (19.28 ± 2.66), which were all higher than the same data of patients in control group: (108.38 ± 14.69), (24.51 ± 2.64), (22.60 ± 3.41), (22.45 ± 3.47), (14.92 ± 2.04), presenting differences with statistical significance ( t values were -9.07 - -2.65, P<0.05). Conclusions:For maintenance hemodialysis patients with itchy skin, the nursing intervention by 321 health education model can effectively ease the itchy skin problem, relieve the impact of itchy skin on patients' lives, and improve the life quality of patients.

Humans ; Male ; Mesylates ; poisoning ; Occupational Diseases ; Occupational Exposure ; adverse effects ; Young Adult

Animals ; Cell Differentiation ; physiology ; Cell Hypoxia ; Cell Line ; Mice ; Myoblasts ; cytology ; Transcription Factors ; metabolism