Objective: To observe the therapeutic effects of RFA combined with chemotherapy drug on hepatic VX: carcinoma in rabbits and to explore its mechanism.Methods: 40 rabbit models with VX: carcinoma were used for this study.they were divided into four groups at random.We watched the changes in serolog ALT,diameter of tumor and pathomorphology.And we also utilized terminal deoxynucleotidyl ransferase-mediated dUTP nick-end-labeling and immunohistochemistry to observe the apoptosis and proliferation.Results: ⑴The blood ALT significantly increased at the first day after treatment,then descended at the third day,and at the seventh day it descended to the level of pretreatment stage in group RFA combined with epirubicin.(2) The diameter of tumor showed significant difference between combined treatment and other groups.(3) Two weeks after treatment,the complete necrotic area slightly extended.it was clearly seen that the zone consisted of normal liver constitution,inflammation hyperemia zone and amorphous necrotic constitution by HE staining in combined treatment group.(4) The apoptosis index of the combined treatment group was bigger than that in other groups by TUNEL technology,but the PCNA index in the combined treatment group was lower than other groups.They all had significant difference.There was negative correlation between apoptosis index and PCNA index in the combined treatment group(r=-0.745,P

10 units allows identification of patients a high risk factors in development ARDS.The high risk fac- tors providing the greatest contribution to improve therapy in acute lung injury and prevent ARDS to occur.

Objective To summarize and analyse the clinical data of death cases in the department of emergency internal medicine. Methods The clinical data of patients presenting at the department of emergency internal medicine from January 2005 to July 2010 were analyzed retrospectively. Results Among 13 211 patients of department of emergency internal medicine, 145 died. More cases died in winter( 32.0% , 39/122 ).More than half of deaths occurred within 6 hours after admission( 54.5% ,79/145 ). The top six death causes were sudden death, pulmonary infection, cerebrovascular accident, advanced cancer, gastrointestinal bleeding,cardiovascular diseases and the occurrence rates were 18. 6%, 13.8%, 13.8%, 10.3%, 9. 7% and 9.0%respectively. Conclusion The first three death causes in department of emergency internal medicine were sudden death, cerebrovascular accident, pulmonary infection. Prevention of these diseases, cooperation between emergency department and other departments and special training on standardized treatment of critically ill patients should be enhanced.

Objective To investigate the clinical features of anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis and the significance of anti-NMDAR antibody assay in clinical diagnosis.Methods Sixty-two patients were divided into 3 groups of encephalitis,encephalopathy and other central nervous system diseases based on their affliction. Anti-NMDAR antibody was detected by transfected cell-based indirect immunofluorescence assay in the serum and cerebrospinal fluid. The clinical features,laboratory tests,treatment and prognosis of NMDAR encephalitis were analyzed.ResultsAnti-NMDAR antibody was positive in serum and (or) cerebrospinal fluid of 9 patients (9/32,28％ ) from encephalitis group.The positive rate of anti-NMDAR antibody in cerebrospinal fluid was higher than that in serum of these patients.Among them,5 patients with higher antibody titer had impaired blood-brain barrier.No tumor was detected in these 9 patients.The most predominant symptoms of anti-NMDAR encephalitis include fever,psychiatric disturbances,seizures,dystonia and autonomic dysfunction.Brain MRI and electroencephalography were also abnormal. Patients were responsive to early immunotherapy. Conclusion Detection of the anti-NMDAR antibody may be important for early diagnosis and treatment of autoimmune encephalitis.

Objective Toinvestigatetheclinicalfeaturesofrecurrentbiliarypancreatitisandrelatedpredisposingfactors.Methods Ato-tal of 272 patients with biliary pancreatitis who were admitted and treated in Jiangbei District People′s Hospital from January 2008 to Decem-ber 2014 were enrolled and divided into recurrence group (56 patients with recurrent biliary pancreatitis)and primary group (216 patients with primary biliary pancreatitis).Clinical features and predisposing factors were compared between the two groups.Comparison of continu-ousdatabetweenthetwogroupswasmadebyttestandcomparisonofcategoricaldatewasmadebychi-squaretest.Results Therewere no significant differences in age and mortality between the two groups (both P>0.05 ).Compared with the primary group,the recurrence group had a significantly higher proportion of males,a significantly increased APACHE-Ⅱscore,significantly increased incidence rates of moderate-to-severe pancreatitis and common bile duct stones,significantly higher rates of stenosis of the common bile duct orifice and hy-perlipidemia,and a significantly higher rate of surgical treatment (all P<0.05).In the recurrence group,the type of pancreatitis differed significantly between patients with 2 times of recurrence and those with >2 times of recurrence (recurrence for more than 2 times)(P=0.040).Compared with the primary group,the recurrence group had a significantly higher proportion of patients with known predisposing factors (80.36%vs 58.33%,P=0.002),as well as significantly higher rates of high-fat diet and drinking (both P<0.05).However, the rates of biliary tract infection and oral administration of drugs showed no significant differences between the two groups (both P>0.05). Conclusion Recurrentbiliarypancreatitisiscommonandsevereinmales,andisoftencomplicatedbycommonbileductstones,stenosisof the common bile duct orifice,and hyperlipidemia,with a high rate of surgical treatment.High-fat diet and drinking are important predispo-sing factors for recurrent biliary pancreatitis.

Moyamoya disease is a chronic progressive cerebrovascular disease. Its main manifestation is bilateral internal carotid artery progressive stenosis w ith abnormal vascular netw ork formation of the compensatory hyperplasia in brain base. The pathological mechanism of moyamoya disease is not clear. Grow ing evidence has suggested that immune inflammation may play an important role in its occurrence and development process. Abnormal expression of various inflammatory cytokines and immune proteins can be observed in patients w ith moyamoya disease. This article review s the possible mechanism of immune inflammation in moyamoya disease in recent years.

Objective To explore the methods for the evaluation of the uncertainty of the determination of hardness in water. Methods A certain water sample was analyzed for the hardness according to EDTA-Na2 volumetry ruled by the Sanitory Standard for Drinking Water(2001).The mathematical model of the determination of hardness in water was established based on JJF1059-1999. The variance composition of the relative uncertainty was analyzed. The procedure of the evaluation of every uncertainty component was described in detail. Results The hardness in the water sample was 137 mg/L calculated according to mathematical model established in this study. The relative uncertainty and the expand uncertainty of the detection of hardness in the water sample were 0.008, 3 mg/L respectively. The expression of the uncertainty in the determination of hardness was (137?3)mg/L. Conclusion This method presented referable value for the evaluation of the uncertainty of volumetry determination method of hardness in water.

OBJECTIVE: To offer support for optimizing marketing strategy and increasing consumption in drug retailing.METHODS: Microsoft SQL Server 2005 database was established,the data mining method was subjected to a correlation analysis using association rules with the daily sales data in a retail drugstore in Jiangsu as an example.RESULTS & CONCLUSIONS: The data mining of drug retailing consists of 4 items: construction of drug sales data mart,data pretreatment,data mining,and analysis of mining results.The application of the data mining in retail drugstore can help analyze the purchase tendency of customers,find out potential customers and increase sales volume.

The "all-free health care" system is being implemented in Shenmu County in Shaanxi Province,whose ethical orientation is during the transitional process from "basic medical insurance" to "meeting residents′ actual healthcare demand".The "all-free health care" system safeguards human health rights,embodies the principle of giving priority to social benefits,and is in accordance with the principle of effectiveness.However,due to the lack of scientific management,the capital flows violate the principle of prevention in the system.