Objective To measure N-acetylaspartate(NAA),choline(CHO) and creatine(Cr) in prefrontal cortex of patients with schizophrenia using in vivo proton magnetic resonance spectroscopy imaging(H'MRSI).Methods H'MRSI was performed on the right and left prefrontal cortex in 20 patients with schizophrenia and 20 normals.The ratio of NAA/Cr to Cho/Cr was determined.Results The NAA/Cr ratio in patients was significant lower than that in normal controls.The CHO/Cr ratio had no significant difference between both groups.Conclusion The neuron function in prefrontal cortex might decrease in first fit schizophrenia.

Objective To explore the relationship between parental rearing behavior and the depressive disorders in adolescents,and to provide objective basis for the prevention and treatment of the depressive disorders.Methods A total of 73 depressed patients were chosen as the disease group,with a control group of 81 healthy persons of similar age,sex,education level and civil status.The depressed patient must meet depressive episode unipolar criteria and HAMD scores were more than 18.Results In males,the scores of father penalty and rejection factors and mother emotional warmth,and over-protection and over-involvement factors were significantly different from those in the control normal group.In females,the scores of father emotional warmth and penalty and rejection factors and mother emotional warmth and rejection factors were significantly different from those in the control normal group.Conclusion Parental rearing behavior plays an important role in the etiology of depression in adolescents.

Objective To explore the contribution of psychoso cial factors including personality and social support to the onset of upper dige stive tract cancer. Methods Ninety-eight patients with up per digestive tract cancer were chosen as disease group, with 98 healthy persons as control group, who matched with disease group in habitation, age, sex and ed ucation level. Both the two groups were studied by Eysenck Personality Questionn aire (EPQ) and social support scale. The differences between the two groups were analyzed. Results The E score of EPQ in disease group was lower than that in control group, but its P and L scores were higher, and the su pport utilization degree in disease group was much lower than that in control gr oup. Positive correlation was found between the E score of EPQ and social suppor t utilization degree in disease group. Conclusion The onset of upper digestive tract cancer is correlated with personality and social suppo rt.

Objective To explore the effects of psychosocial f actors including life events and coping style on the onset of upper digestive tr act cancer. Methods A total of 98 patients with upper diges tive tract cancer were chosen as experiment group, while 98 healthy persons were chosen as control group, who matched with experiment group in habits, age, sex and education background. Both the two groups were studied by Life Event Scale a nd Simplified Coping Style Questionnaire. The difference between the contributio n of psychosocial factors in the two groups was analyzed. Results The stimulating amount and frequency of negative life events in experimen t group were much higher than those in control group, while those of its positiv e life events were much lower. The total score of passive coping style in experi ment group was higher than that in control group, while the total score of posit ive coping style was lower. Conclusion Stress may be one of the etiological factors in causing upper digestive tract cancer, and passive co ping style may also be a risk factor for the etiology of upper digestive tract c ancer.

Objective To explore the personality characters of patients with mental disorders and to determine the differences of dimension,trait level and model of personality between patients and normal subjects.Methods The patients with mental disorders(n=376) and normal subjects(n=368) were assessed with revised NEO personality inventory(NEO-PI-R).Results The mean scores of extroversion(E) and conscientiousness(C) of five-factor personality model of NEO-PI-R in patients were significant lower than those in normal group((P

Objective To measure metabolism in brain of first episode major depression patients with 1H-MRS.Methods Single-voxel proton magnetic resonance spectroscopic(1H-MRS) examination of bilateralis frontal lobe and hippocampus was conducted in 23 patients with first episode major depression and 23 age-,sex-and education-matched healthy controls.We examined the metabolism such as NAA,Cho,Cr,Glx and mI in bilaterlis frontal lobe and hippocampus of patients.Results Bilateralis frontal lobe NAA/Cr,right frontal lobe Glx/Cr and left hippocampus NAA/Cr and Glx/Cr were significantly lower in MD patients versus controls,but right frontal lobe and right hippocampus mI/Cr significantly higher than in controls.Conclusion Nerve cell activity disorder,abnormal second messenger and glutamicacid and glutamine may be involved in the pathogenesis of major depression.

Objective To investigate the change of plasma ghrelin level and explore the related factors of ghrelin alteration in elderly hypertensive patients with psychological distress. Methods A total of 300 elders, who were screened with Hamilton Anxiety Scale (HAMA), Hamilton Rating Scale for Depression (HAMD), and the Symptom Checklist-90 (SCL-90) for psychological stress and somato-psychological manifestations respectively, were divided into hypertension group (n=148) and non-hypertension group (n=152). Their blood samples were collected to measure the plasma level of ghrelin and total cortisol on the same day. Results The incidences of anxiety and depression were 27.7% and 11.7%, respectively, in all the enrolled elders. However, the rates of psychological distress, particularly anxiety, were significantly higher in the hypertensive elders than in the non-hypertensive ones (43.2% vs. 12.5%). Anxiety was positively related to the cortisol level but negatively related to the plasma ghrelin level, and the latter two were negatively correlated with each other. Conclusion Chronic increase of plasma cortisol induced by long-term anxiety can lead to the reduction of ghrelin level, which then adversely affects blood pressure in elders with psychological distress. Therefore, ghrelin might be a selective antihypertensive medicine for hypertensive elders with anxiety.

【Objective】 To revise the Highly Sensitive Child (HSC) Scale for Chinese Adolescents and investigate the role of adolescents’ sensitivity to environmental influences. 【Methods】 The HSC Scale was translated into Chinese. A total of 2166 adolescents in Xi’an were selected for exploratory factor, confirmatory factor analyses and reliability analysis. The participants were 609 healthy adolescents and 105 depressive adolescents aged 14-17 years, who were evaluated with the HSC scale and PHQ-9 scale as well as sleep duration and academic achievement questions. 【Results】 First, the factor structure (CFI=0.989, GFI=0.977, AGFI=0.958, TLI=0.983, RMSEA=0.042, RMR=0.050) indicated that HSC scale was a reliable measure of environmental sensitivity. The results supported a bifactor model with a general sensitivity factor and three group factors. Second, the Cronbach α was 0.892, and the test-retest reliability coefficient was 0.743. Third, depressive adolescents had a significantly higher HSC score, compared with the healthy ones (F=15.1, P<0.01). Fourth, the relationship between BMI and adolescent adjustment was moderated by environmental sensitivity. Simple slope analysis showed that when the level of environmental sensitivity was higher, weight gain could predict adolescents’ emotional, sleep and academic problems. 【Conclusion】 The Chinese version of HSC has good psychometric characteristics and may be applied in Chinese adolescents. Environmental sensitivity may be a personality factor that influences depressive symptoms in adolescents.

【Objective】 To examine the joint effects of parent-child relationship and environmental sensitivity (ES) on adolescent mental health from the perspective of sensitivity X family conflict interaction. 【Methods】 In 2023, we investigated 7,010 adolescents from six junior high schools in Shaanxi Province, China. Self-reported questionnaires were used to assess parent-child relationship, ES, and adolescent mental health. ES was assessed by Highly Sensitive Child Scale (HSC); Patient Health Questionnaire-9 (PHQ-9), Strengths and Difficulties Questionnaire (SDQ), and Happiness index were used to measure depression, externalizing problems, and subjective well-being. 【Results】 ① Girls’ ES scores were significantly higher than boys’ (t=-7.504, P<0.01). ② When predicting depression and externalizing problems, the main effects of parent-child relationship and ES in adolescents were significant (b=-0.263, 0.237, 0.332, P<0.001; b=0.201, 0.220, P<0.001), and the interaction between family conflicts and ES was significant (b=-0.072, P<0.05; b=0.092, P<0.05). (3) Widaman’s confirmatory and competitive approach results showed the significant interaction of sensitivity X family conflict with depression and externalizing problems, which were consistent with the differential susceptibility and diathesis-stress framework, respectively (BIC=2 170.98, 2 162.6). 【Conclusion】 Adolescents with high environmental sensitivity suffer more from high family conflict and benefit more from low family conflicts. These sensitive adolescents can be described as having developmentally susceptibility rather than vulnerability.