Objective To evaluate the efficacy and safety of allicin in patients with Behcet's disease (BD). Methods Thirty-eight patients with BD that was mainly involved skin, mucosa and joints were divided into treatment group ( 20 cases) and control group (18 cases) by randomized digital table method. Two groups of patients were respectively assigned to receive allicin tablets and identical placebo vehicles for 12 weeks, and were followed up to 16 weeks. The changes of clinical symp-toms and laboratory detection were observed in the time of pretreatment and post-treatment in two groups. Meanwhile, the ef-ficacy and side effects were compared between both groups. Results A total of 31 patients completed the experiment. The effective rate was 88.89%in treatment group, which was significantly higher than that of the control group (7.69%, P<0.01). After administration of allicin or placebo, there was no significant difference in white blood cell (WBC) count between treat-ment group and control group(P>0.05). The levels of ESR and CRP were significant lower in treatment group than those in pretreatment and control group (P < 0.01). Although allicin displayed some adverse reactions, most patients could tolerate them, and these side effects tended to dissipate once the drug ceased. Conclusion Allicin is a safe and effective drug in the treatment of BD, which is significantly better than placebo, and is worth to be further researched and promoted.

Objective To explore the therapeutic effect and the mechanism of allicin on experimental Behcet′s disease (BD) . Methods BD models were established .Then ,model mice were randomly divided into experimental group ,positive control group and negative control group ,with respectively nasogastric infusion allicin ,colchicine and saline respectively .Before and after treatment , the changes of the skin lesions were visually observed .Cytokines of IFN‐γ,TNF‐αand IL‐4 in serum were detected by ELISA anal‐ysis ,while the markers of T‐AOC ,MDA ,SOD and GSH‐PX by chemical colorimetric methods .Results After modeling ,ulcers ap‐peared on the back ,abdomen and genital of model mice with IFN‐γ,TNF‐α,IL‐4 and MDA elevation ,while T‐AOC ,SOD and GSH‐PX decrease .Twenty days of treatment later ,ulcer on mice in the experimental group and positive control group healed .After 30 days ,only two mice in the experimental group recurred ,while 6 mice in the positive control group ,which showed a significant differ‐ence between two groups (P<0 .05) .After treatment ,IFN‐γ,TNF‐αand IL‐4 levels in the experimental group were markedly low‐er than pretreatment (P<0 .01) ,but no significant difference compared with the positive control group (P>0 .05) .Meanwhile ,T‐AOC ,SOD and GSH‐PX levels in the experimental group were significantly higher than those in the pretreatment ,but MDA was lower (P<0 .01) .In comparison with the positive control group ,levels of those markers in the experimental group changed remark‐ably (P<0 .05) .Conclusion Allicin is an effective drug in the treatment of experimental BD .The therapeutic mechanism of allicin may be the inhibition of inflammatory mediators and prevention of oxidative stress .

Objective To observe the change and relation between heart rate variability (HRV) and renin-angiotensin-aldostemne system (RAAS) under epidural anesthesia.Methods 16 cases patients ASAⅠ-Ⅱwere chose for epidural anesthesia.HRV,MAP and RT had been monitoring at pre-anesthesia (T1),15 min after inducing (T2),1 min after incising (T3),1 min pre-probing (T4),5 min after dragging uterus (T5), 1min after cutting uterus (T6) and the end point (T7).At same time,renin angiotensin and aldostemne were measured by drawing radial arterial blood when it was T1,T2,T3,T5,T7.Results Comparing with T1,LF/ HF increased significantly (P

Objective: To assess the value of transesophageal echocardiography (TEE) during cardiac surgery. Method: Intraoperative TEE was performed to record left atrial gas during and for 15 minutes after bypass in 131 pa tients and to evaluate mitral regurgitation after mitral replacement in 38 patients. The degrees of the gas and mitral re gurgitation by TEE was visually quantified on a 4-point scale(0 to 3) and a 5-point scale(0 to 4), respectively. Result: The left atrial gas was detected in 115(88%)patients, two of which with positive echograms(gas grade=3). There was significant improvement in the mean mitral regurgitation grade after mitral replacement (3.4?0.6 to 0.5?0.2, P

Humans ; Occupational Health Physicians ; organization & administration ; Personnel Selection

OBJECTIVETo observe and evaluate the clinical effect of acupuncture at "Siguan" combined with the Gallbladder Meridian acupoints on migraine.

METHODSWith randomized controlled trial design, 87 patients were randomly divided into an observation group (42 cases) and a control group (45 cases). The observation group was treated with acupuncture at "Siguan" including Hegu (LI 4) and Taichong (LR 3), combined with the Gallbladder Meridian acupoints including Fengchi (GB 20), Shuaigu (GB 8), Qiuxu (GB 40) and Zulinqi (GB 41), while the control group was treated with acupuncture at the Gallbladder Meridian acupoints, including Fengchi (GB 20), Shuaigu (GB 8), Qiuxu (GB 40), Zulinqi (GB 41), Yanglingquan (GB 34) and Hanyan (GB 4). The treatment was given every other day in two groups, 3 times per week for totally 6 weeks. The migraine intensity, migraine frequency and lasting time of each migraine were observed before and after treatment, and 3-month follow-up was performed after treatment. The clinical efficacy in two groups was evaluated.

RESULTSCompared with those before treatment, the migraine intensity, frequency and lasting time were all reduced significantly after treatment in the two groups (all P<0.01), which were more obvious in the observation group (all P<0.05). At the end of the treatment, the total effective rate was 95.2% (40/42) in the observation group and 80.0% (36/45) in the control group, which had statistical difference (P<0.05). After 3-month follow-up, the total effective rate was 88.1% (37/42) in the observation group and 75.6% (34/45) in the control group, which had no statistical difference (P>0.05).

CONCLUSIONThe "Siguan" combined with the Gallbladder Meridian acupoints could significantly relieve the migraine intensity, frequency and lasting time, and its improvement of symptoms and short-term efficacy are superior to those of the Gallbladder Meridian acupoints alone.

Acupuncture Points ; Acupuncture Therapy ; Adolescent ; Adult ; Female ; Gallbladder ; physiopathology ; Humans ; Male ; Meridians ; Middle Aged ; Migraine Disorders ; physiopathology ; therapy ; Young Adult

Objective To investigate the radiosensitizing effects of cyclooxygenase-2 selective inhibitor LM-1685 on A549 cells in vitro.Methods A549 human lung adenocarcinoma cell line was used in this study.Cell growth kinetics Was determined using MTT assay.Cell survival was analyzed by clonogenic assay.The change of cell cycle Was measured by flow cytometry.Results LM-1685 inhibited the growth of A549 cells,showing a dose-dependent and time-dependent manner.LM-1685(50/μmol/L),either with or without IL-1β,showed the radiosensitizing effects on A549 cells,and the sensitizing enhancement ratio(SER)was 1.12 and 1.06,respectively.LM-1685(50 μmol/L)abrogated radiation-induced G2/M arrest of the tested A549 cells.Conclusions Cyclooxygenase-2 selective inhibitor can enhance the radiosensitivity of A549 cell line.Abrogation of radiation-induced G2/M arrest could be part of the mechanism.

BACKGROUND: Mongolian osteopathy is famous for the complicated manipulation and theoretical complexity. Combined with the finite element model of ulna-radius fractures, the analysis on the manipulation of osteopathy has not been reported at home and abroad. OBJECTIVE: To simulate the force of various ulna-radius fractures and establish the model of ulna-radius fractures, to analyze the effect, and to analyze the manipulation mechanism of Mongolian osteopathy on the corresponding fractures. METHODS: One 35-year-old volunteer was selected to obtain the CT image data of the right forelimb after signed the informed consent. The geometric model of the radius and ulna was established based on the parameters of bone tissue. The material mesh was divided, and the load parameters were assigned for analysis and calculation. Based on the common causes of Colles and Smith fractures, the osteopathy manipulation was evaluated by combined with “force to force” of Mongolian osteopathy. RESULTS AND CONCLUSION: (1) The stress distribution of the model of ulna-radius fractures is highly consistent with previous studies of the forearm. The mechanical models of Colles and Smith fractures were obtained in the direction of stress. After adjusting the mechanical parameters of bone, the fracture models of four different ages could be simulated. (2) These results indicate that the finite fracture model is feasible. Meta-analysis could simulate the ulna-radius fractures, and provide a manual reference for treating ulna-radius fractures with “force-to-force” theory in Mongolian osteopathy.

BACKGROUND: Soft silicone silver ion dressing, a kind of high molecular weight organic compound prepared with Safetac technology, has the characteristics of anti-infection, good permeability and good air permeability. It can provide a good moist environment for wound healing. OBJECTIVE: To evaluate the effectiveness of soft silicone silver ion dressings in repairing deep II degree and milder burn wounds. METHODS: A computer-based retrieval of CNKI, VIP, WanFang, CBM, PubMed, Embase and Web of Science databases was performed. The randomized controlled trials concerning soft silicone silver ion dressing for repairing deep II degree and milder burn wounds were selected. The treatment group was treated with a single soft silicone silver ion dressing, or a soft silicone silver ion dressing combined with conventional treatment, or combined with other treatments. The control group was treated with conventional treatment, or other treatments, or placebo. After screening, data extraction and quality evaluation, meta-analysis was performed using Review Manager 5.3 software. RESULTS AND CONCLUSION: (1) Eleven articles were included, involving 784 patients, 381 patients in the treatment group and 403 patients in the control group. (2) The results of meta-analysis showed that the burn wound healing rate in the treatment group was higher than that in the control group [OR=11.56, 95%CI (9.60, 13.53), P < 0.000 01; OR=13.29, 95%CI (7.54, 19.04), P < 0.000 01; OR=4.10, 95%CI (2.28, 5.93), P < 0.000 1; OR=1.17, 95%CI (0.42, 1.93), P=0.002] at 7, 14 and 21 days, and the last measurement. The healing time of burn wounds in the treatment group was shorter than that in the control group [OR=-2.81, 95%CI (-3.49, -2.12), P < 0.000 01]. The degree of pain in burn wounds in the treatment group was lower than that in the control group [OR=-0.38, 95%CI (-0.53, -0.24), P < 0.000 01]. There was no significant difference in the positive rate of bacterial culture on wound surface [OR=1.16, 95%CI (0.47, 2.85), P=0.74], burn wound infection [OR=1.44, 95%CI (0.47, 4.41), P=0.52], dressing frequency [OR=-8.04, 95%CI (-18.82, 2.74), P=0.14], wound treatment cost [OR=-98.26, 95%CI (-272.91, 76.40), P=0.27] and adverse reaction [OR=0.61, 95%CI (0.31, 1.20), P=0.15] between treatment and control groups. (3) These results show that the application of soft silicone silver ion dressing on deep II degree and milder burn wounds can improve wound healing rate, shorten wound healing time and alleviate pain.

BACKGROUND: At present, platelet-rich plasma has been used in bums, plastic surgery, surgery and orthopedics. However, due to the different standards for platelet-rich plasma preparation, the results of research on bums are controversial. OBJECTIVE: To systematically evaluate the effectiveness of platelet-rich plasma in the repair of burn wounds. METHODS: A computer-based online search of CNKI, VIP, WanFang, CBMdisc, PubMed, Embase, CochraneLibrary, Web of Science databases to retrieve randomized controlled trials regarding platelet-rich plasma repair of bum wounds. In the treatment group, platelet-rich plasma therapy or platelet-rich plasma therapy combined with conventional or other therapies were used. In the control group, conventional therapy, other therapies, or placebo treatment were used. After literature screening, information extraction and quality evaluation, Review Manager 5.3 software was used for meta analysis. RESULTS AND CONCLUSION: Eleven articles were included, involving 837 patients consisting of 420 patients in the treatment group and 417 patients in the control group. Meta analysis results revealed that the wound healing rate in the treatment group was significantly higher than that in the control group [OR=12.61, 95%Cl (6.93,18.29), P<0.000 1], Wound healing time in the treatment group was significantly shorter than that in the control group [OR=-4.64, 95%Cl (-6.21, -3.06), P<0.000 01]. The number of layers of gauze soaked by dressing [OR=-4.01, 95%Cl (-4.91, -3.11), P<0.000 01], the times of changing inner gauze [OR=-3.79, 95%Cl (-5.33, -2.26), P<0.000 01, and the times of dressing change on wound surface [OR=-3.41, 95%Cl (-5.93, -0.88), P=0.008] in the treatment group were significantly less than those in the control group. The positive rate of bacterial culture in wound [OR=0.46, 95%Cl (0.22, 0.94), P=0.03] and the incidence of inflammatory reaction in wound [OR=0.30, 95%Cl (0.17, 0.56), P=0.000 1] in the treatment group were significantly lower than those in the control group. The results suggested that platelet-rich plasma can increase the wound healing rate, shorten wound healing time, reduce the number of layers of gauze soaked by dressing, the times of changing inner gauze, and the times of dressing change on wound surface, and lower the positive rate of bacterial culture and the incidence of inflammatory reaction in wound.