Objective:To explore whether CD36 deficiency promotes insulin resistancein the C57BL/6 mice.Methods:Micewerefedwith a high-fat die(tn=7)for 14 weeks.Intravenous glucose tolerance tests,insulin release and tolerance tests were performed.Triglyceride and free fat acid levels in serum were measured.Results:Compared with the C57BL/6 mice,blood levels of glucose,insulin,triglyceride and free fatty acid were increased in the CD36 knockout mice.Conclusion:The CD36 deficiency indeed promotes insulin resistance in the C57BL/6 mice.

Enterovirus A, Human ; Enterovirus Infections ; pathology ; Female ; Hemorrhage ; etiology ; virology ; Humans ; Infant ; Male ; Pulmonary Edema ; etiology ; virology

Systemic Inflammatory Response Syndrome ; virology ; Virus Diseases

Asian Continental Ancestry Group ; China ; Humans ; Sepsis ; Terminology as Topic ; Translations

Anti-Bacterial Agents ; therapeutic use ; Child ; Humans ; Practice Guidelines as Topic ; Sepsis ; classification ; complications ; diagnosis ; drug therapy ; physiopathology

Objective To investigate the clinical effect of insulin therapy in the treatment of patients with polycystic ovary syndrome .Methods 91 cases of endocrine disorders of patients with polycystic ovary syndrome were selected from September 2013 to September 2016 in Yinzhou Ningbo people’s hospital,and divided into observation group and control group,44 cases in the control group and received conventional treatment,47 cases in the observation group and received insulin sensitizer on the basis of conventional treatment.Before and after treatment, the level of sex hormones, blood glucose and insulin levels in the two groups were detected and compared,and the efficacy was determined and compared.Results Compared with before treatment,the levels of LH,FSH,E2,T,A2,Ds in the observation group were decreased,SHBG was increased,HOMA-β,HOMA-IR,FPG,FINS were decreased,the difference was statistically significant (P<0.05);compared with control group, the levels of LH,FSH,E2,T,A2,Ds in the observation group were lower,SHBG was higher,HOMA-β,HOMA-IR,FPG,FINS were lower,the difference was statistically significant (P<0.05);After treatment, the total effective rate of observation group 95.74%was significantly higher than the control group 81.82%(P<0.05).Conclusion Insulin sensitizer in treatment of polycystic ovary syndrome in patients with endocrine disorders has significantly effect,can significantly improve the patient’s sex hormone levels and blood glucose levels,adjust the patient’s insulin levels,improve the clinical treatment efficiency.

Objective To estabilish a HPLC method for the determination of Geniposide in Jigucao Capsule. Methods The column was Lichrospher-C18(5 ?m,4.6 mm?250 mm). The determination was carried out with acetonitrile-0.1% phosphoric acid(10∶90) as the mobile phase,a flow rate of 1.0 mL/min and detected at 238 nm,and temperature of the column was 35 ℃. Results The calibration curve showed good linearity in the range of 0.14～1.68 ?g,Y =1 552.15X-6.42,r=0.999 9. The mean recovery was 97.53%(RSD=1.24%,n =6). Conclusion The method is accurate,reliable,and can be used for quality control of the preparation.

Medicine is a practicing and experiencing subject.The most important study method for medical students is to practice during clinic.With the development of society,patients' consciousness of sticking up for their rights is stronger and stronger.During their receiving medical treatment,they are not satisfied with the teaching behavior provided by physician,and even to make medical conflicts.To resolve these conflicts,it is necessary to rule the clinical practicing teaching,harmonize the relationship between clinical teachers,medical practicing students,and patients.Medical education should be based on humanity and should be behaved by law.

Objective To investigate the clinical application of low dose chest CT examination with PACS/RIS-HIS-Health screening system.Methods 6038 subjects underwent chest low-dose CT examination were retrospectively analyzed in this study. With or without PACS/RIS-HIS-Health screening system,the physical examination workload per day,average examination duration and waiting duration were retrospectively calculated and compared,respectively.Results At the same working hours,the low dose chest CT screening workload was sharply increased from 73.87 to 127.4 per day (t=11.526,P<0.001).The mean CT examina-tion duration was decreased from 2.58 to 1.8 minutes per subject (t=8.443,P<0.001).30 percent of waiting duration were saved approximately (t=6.951,P<0.001).All the related management departments could do statistics and analyze the data online with high efficiency via the screening system.Conclusion PACS/RIS-HIS-Health screening system can optimize the workflow and im-prove the work efficiency of chest low-dose CT screening.

The author reviewed papers on Evaluation on Teaching Hospitals in China from 1997 to now.Teaching hospitals were evaluated by educational and health administrator of local government since 1997.The methods the roles of evaluation,advantage and disadvantage of evaluation on teaching hospitals were described in this paper.