Objective To explore the influence of shenmai injection on C-reactive protein(CRP) and homocysteine(Hcy) of patients with non-ST-segment elevation acute coronary syndrome.Methods 96 patients with nonST-segment elevation acute coronary syndrome were randomly divided into the control group(48 cases) and the observation group(48 cases).The patients in the control group were treated through the conventional treatment,while the patients in the treatment group were treated by shenmai injection based on the conventional therapy.They were all treated for 14 days.CRP and Hcy were detected before and after treatment.Results The total effective rate of the observation group was 95.8％,which was significantly higher than 87.5％ of the control group (x2 =4.760,P ＜0.05).The plasma levels of CRP and Hcy were all decreased after treatment in both two groups.The CRP and Hcy in the observation group were significantly lower than those in the control group (t =2.927,2.624,all P ＜ 0.05).Conclusion Shenmai injection can significandy decrease the plasma levels of CRP and Hcy in patients with non-ST-segment elevation acute coronary syndrome.

Objective To study the effect of femoral offset reconstruction ON the Harris hip score and the hip ROM (range of motion) after artificial hip replacement in femoral neck fractures. Methods Follow-ups were conducted for 47 patients who had undergone artificial hip replacements for their unilateral femoral neck fractures. We took X-ray pictures to compare the femoral offsets at the affected and unaffected hips. The operated hips were evaluated by the Harris hip score. Statistical analyses were performed with SPSS l2.0 software. Results The Harris hip score of the operated hip was positively related to femoral offset reconstruction(t=7.25,P＜0.001).There was a significant and positive correlation between femoral offset and the hip abductor ROM(r=0.80,P＜0.001).The rate of femoral offset reconstruction had no significant difference between total hip arthroplasty and bipolar hip arthroplasty (χ2=0,P＞0.05).Conclusions Reconstruction of femoral offset after artificial hip replacement in the femoral neck fractures can improve funetional recovery and ROM of the hip. Femoral offset reconstruction is uncorrelated to the selection of total hip arthroplasty or bipolar hip arthroplasty.

OBJECTIVE: To bring forward feasible suggestions for Direct-to-Consumer(DTC) marketing of prescription drugs.METHODS: The importance of analysis of DTC marketing of prescription drugs in solving "unrealistically high" drug price because of asymmetric information and its role in sufferers' participating in self-health care were analyzed.The status quo and the problems faced in US DTC marketing were also analyzed.RESULTS & CONCLUSIONS: The marketing of prescription drugs can be extended to the sufferers in China,but we must pay attention to the checkup for DTC advertisement,the time of DTC advertisement being forbidden after the new drugs launched into the market and the scope for DTC marketing.

Mesenchymal stem cells (MSCs) are adult stem cells which derived from the embryonic mesoderm. They have a high proliferative ability and can differentiate into various tissues of mesodermal origin including bone, cartilage and adipose tissue in vitro. Moreover, MSCs have also been shown to produce anti-inflammatory molecules which can modulate cellular and humoral immune responses. Because of their easy preparation, the capacity for self-renewal, multi-lineage differentiation and immunoregulatory effect, MSCs therapy becomes a promising tool in the treatment of tissue regeneration, anti-inflammation, and autoimmune diseases. In this review we will focus on the application of MSCs for nasal inflammation disease.
Adult Stem Cells ; transplantation ; Autoimmune Diseases ; Cell Differentiation ; Humans ; Inflammation ; therapy ; Mesenchymal Stem Cell Transplantation ; Mesoderm ; cytology ; Nose Diseases ; therapy ; Wound Healing

Dermcidin (DCD) was found in isolated human skin sweat glands with antimicrobial effect, and was defined as a kind of new small molecule antimicrobial peptide. It was a part of human sweat glands in the skin as the immune system's innate defense. With the studies of DCD, its extensive biological functions are gradually discovered. Since 2010, a number of studies have shown that DCD may be a new risk factor for atherosclerosis. And the role of DCD in ischemic heart disease has drawn increasing attention in particular its relationship with insulin secretion and glycemic control, nitric oxide (NO) synthesis and hypertension, platelet aggregation and acute myocardial infarction (AMI). In those experiments, it was also confirmed that aspirin had antagonistic and reverse effects on various biological functions of DCD. Further research on the role of DCD in cardiovascular and cerebrovascular diseases may lead to the prevention, early warning, prognosis evaluation and treatment breakthrough of cardiovascular and cerebrovascular events.

OBJECTIVE To investigate the evolution of drug-resistance of Staphylococcus aureus in children in Hubei tertiary level hospitals during four years and provide the evidence for clinically reasonable use of antibiotics.METHODS The summary data of drug sensitivity in clinical isolates of meticillin-resistant S.aureus(MRSA) and meticillin-sensitive S.aureus(MSSA) in children in Hubei tertiary level hospitals from 2004 to 2007 were investigated retrospectively and the results were analyzed statistically.RESULTS The tendency of infections with MRSA upgraded yearly during four years(5.7%→10.7%→40.8%→46.9%);the resistance rates of MRSA to various antibiotics were all higher than that of MSSA.The vancomycin-resistant S.aureus had not been detected.CONCLUSIONS The drug-resistance status of SA in Hubei is still very serious.We should adopt effective measurement to control the occurring and epidemic outbreak in combination with children physiological characteristic.

OBJECTIVE:To evaluate the clinical efficacy of combination of low molecule heparin calcium with Asipilin for early acute cerebral infarction.METHODS:A total of 320 patients with early acute cerebral infarction were randomly assigned to low molecule heparin calcium group,aspirin group,combination treatment group(low molecule heparin calcium group plus aspirin)or control group.The clinical efficacy in 4 groups was evaluated respectively.RESULTS:The nerve function showed a better recovery in all the treatment groups than in control group.As compared with low molecule heparin calcium group or aspirin group,the combination treatment group showed a significantly improved nerve function and higher clinical efficacy.There were significant differences in total effective rate among groups after treatment for different time(P0.05).CONCLUSION:The combination of low molecule heparin calcium with Asipilin for early acute cerebral infarction is safe and more effective than low molecule heparin calcium and Asipilin used alone.

Polycomb group proteins Bmi-1 is the core subunits of the PRC1 complex,and also plays important roles in the regulation of neural development. This review introduces the construction of Bmi-1 and the recent study for Bmi-1 in the nervous system development and tumor generation. The important roles of Bmi-1 for sustain of the neural stem cell proliferation,regulation mechanism of neural development and tumor generation are discussed.

Objective:Comparative analysis of total parathyroidectomy (total parathyroidectomy, TPTX) and total parathyroidectomy with autoransplantation (total parathyroidectomy with autoransplantation, TPTX+ AT) for the treatment of uremia secondary hyperparathyroidism Clinical efficacy.Methods:A total of 82 cases of SHPT treated with TPTX or TPTX + AT in First Affiliated Hospital of Chengdu Medical College from June 2015 to July 2019 were collected According to the operation methods, 82 cases were devided into TPTX group and TPTX+ AT group.There were 34 patients in the TPTX group, 17 males and 17 females, with an average age of (45.97±8.96) years, and 48 patients in the TPTX+ AT group, 21 males and 27 females, with an average age of (49.12±7.30) years. SPSS 20.0 software was used for statistical analysis. The measurement data conforming to normal distribution were represented by ( Mean± SD), and the comparison between groups was performed by t test. The data not conforming to normal distribution were represented by quaternary M( P25, P75), and the comparison between groups was performed by non-parametric test. Enumeration data were expressed as cases (%), and comparison was performed by χ2 test. The postoperative complications, postoperative efficacy and recurrence rate were compared between the two procedures. Results:Both TPTX and TPTX+ AT had a low incidence of complications after SHPT, and both of them could effectively relieve symptoms such as bone pain, skin itching and subcutaneous soft tissue calcification.After 1 year of follow-up, both of the two surgical methods can effectively reduce blood calcium (TPTX group: t= 14.522, P<0.05; TPTX+ AT group: t=13.704, P<0.05), blood phosphorus (TPTX group: t=35.022, P<0.05; TPTX+ AT group: t=42.303, P<0.05) and iPTH(TPTX group: t= 20.166, P<0.05; TPTX+ AT group: t= 23.976, P<0.05), but the reduction of iPTH in TPTX group was more effective than that in TPTX+ AT group ( t=-3.416, P<0.05). Conclusion:Both TPTX and TPTX+ AT can effectively treat SHPT, and have high safety and can be used as an alternative for SHPT treatment.

Objective To explore the most suitable condition of influenza virus which was culturing on plateau region,and im-prove the effect of the separation of influenza virus.Methods The original specimens were respective inoculated in MDCK cells,by comparing CO2 percent concentration (5%,4.8%,4.6%,4.4%,4.2%),TPCK-pancreatic enzyme dosage (1,2,3, 4,5μg/m and 6,8,10μg/ml),inoculation amount (100,200,300,400,500μl),incubation time (48,72,96,120,144 h),inoc-ulation methods (adsorption,direct inoculated),and culture vessel(cells,6 orifice)that were influenced on influenza virus, the best culture conditions was determined.Hemagglutinatio (HA)method was used to detect the virus titers.Results Through the comparison,the HA titer of virus was in the highest titer with 6 orifice plate culture vessel,4.4% CO2 and 4.6% CO2 ,2μg/ml TPCK-pancreatic enzyme,300μl and 400μl inoculation amount,72h~96h of incubation time.Conclusion The optimal condition of the influenza virus cultured with the MDCK cell has been established in the laboratory on plateau region.