Objective To study the value of CT and MRI(3D heavy T_2WI) in cerebrospinal fluid rhinorrhea.Methods 4 cases with spontaneous cerebrospinal fluid (CSF) rhinorrhea confirmed by operation were collected in this study.There were 2 men and 2 women.All patients underwent CT thickness was 0.625 mm and no gaps.MRI (coronal 3D heavy T2WI,thickness of 1 mm,TR/TE 5000 ms/119 ms).Results All 4 cases accepted the treatment of operations.The defects bone were showed by CT,and the sign of CSF of intracranial cavity communicated with nasal cavity diretly was showed by MRI,pituitary herniated into sphenoid sinus in one case also showed by MRI.Conclusion For spontaneous cerebrospinal fluid rhinorrhea,thin-section coronal CT scan and MR coronal 3D heavy T_2WI can clearly show the location of fistulas.

Objective To analyze the etiological factor for hypo-side agglutination in cross match blood test(CMT)with microcolumn gel assay,and to provide a guide to the clinical blood transfusion.Methods The data were collected and analyzed about 81 cases with hypo-side agglutination in CMT with microcolumn gel assay and direct antiglobulin test(DAT)positive from Jan.2007 to Oct.2008.Results Among the 81 hype-side agglutinated cases,most were with kidney disease,liver and gall disease,hematologic disease and immunologic disease.Specially,the kidney disease was most,accounting for 16.2%.Conclusion The analysis contributes to disposal in CMT and the safety of clinical blood transfusion.

Objective To investigate the clinical and pathological features of children malignant lymphoma.Method A retrospective study was carried out to analyse the clinical,laboratory and pathological data in 65 patients with malignant lymphoma.Results In the chidren malignant lymphoma,the incidence of nonHodgkin′s lymphoma(NHL) was more than that of Hodgkin′s disease(HL),the ratio of NHL to HL was 2.25∶1.The peak incidence of age was among 6 to 9 years old,the ratio of male to female is about(3.5∶1.)NHL of our children was mostly consised of lymphoblastic lymphoma,anaplastic large-cell lymphoma,diffuse large B-cell lymphoma and Burkitt′s lymphoma.The clinical manifestations were predominantly presented with peripheral nodes intumescing,mediastinal tumeur,abdominal tumeur,bone marrow infiltration.In patients with Hodgkin′s disease,mixed cellularity was the most common pathological category,and cervical painless lymphadenectasis was usually the initial signs in most patients,sometimes accompanied with infiltration of celiac lymph nodes,spleen and bone marrow.Conclusions NHL of our children differs from that of adult in the clinical feature and pathology,while HL of our patients is similar to adults.Since the prognosis of the malignant lymphoma is determined by its pathology,immunohistochemistry plays an important role in the diagnosis and differential diagnosis.J Appl Clin Pediatr,2006,21(3):160-161

The changes of active oxygen species and some enzymes in Grifola umbellata induced by Armillaria mellea elicitor were studied.The results showed that active oxygen species appeared in both mycelia and sclerotia of G.umbellata after treated with A.mellea.There were two phases of active oxygen production upon addition of A.mellea elicitor.Phase I occured at 10 minute after addition of A.mellea elicitor.Phase Ⅱ occurred about 90 minute.The changes of some enzyme activity were also studied in this paper.Compared with control,the A.mellea elicitor could reduce the activity of superoxide dismutase and peroxidase.The catalase activity changed only little.The phenylanine ammonia lyase activity declined in the early stages and then increased in the late stages.

Few studies of cetuximab on patients with gastric and esophageal cancer were available now.The disease control rate was 72.7%～92%,OS was 9.5～16.6months,PFS/was 6.2～11 months among first-line setting with cetuximab-contained regimens.And cetuximab shown in second-line regimen setting overcome the resistance of irinotecan and docetaxel.The pCR was 13%～65% when cetuximab was used as induction treatment combined with concurrent chemoradiation.18F-FDG-PET was a potential method to predictthe efficacy of cetuximab-contained regimens,however,status of Kras gene had no predictive value.

Objective To study the level of serum vascular endothelial growth factor(sVEGF)in advanced non-small cell lung cancer(NSCLC) and its clinical significance.Methods Serum level of VEGF was detected by ELISA method in 96 patients with advanced NSCLC.sVEGF level was analyzed after giving 2-4 cycles of cisplatin-based chemotherapy.At the same time,serum level of VEGF in 50 healthy controls was detected.Results The level of sVEGF was significantly higher in patient with lung cancer than in control group (P＜0.01).No statistical significant defference was observed between sVEGF level of stage Ⅲ and Ⅳ NSCLC patients,the patients with squamocellular lung cancer and adenocarcinoma(P＞0.05);Descended sVEGF level was found in the patients with response to chemotherapy(P＜0.05).Conclusion sVEGF can be used to evaluate chemotherapy response and diagnoses in the patients with advanced NSCLC.

Objective To observe the efficacy of Foley balloon combining with uterine adhesions to prevent the recurrence of intrauterine adhesions after resection of intrauterine adhesions.Methods Patients underwent resection of intrauterine adhesions were randomized into two groups. 30 patients in control group underwent the therapy of uterine adhesions to prevent the relapse intrauterine. On the other hand, the study group with 30 patients were placed Foley balloon for 5 ~ 7 days and combined with the therapy of uterine adhesions to intervention for 1 ~ 2 weeks. All patients were followed-up for 1 ~ 2 months, and the result of the intrauterine adhesion were assessed by hysteroscopy.Results The rate of the relapse in control group was 3.33%; the study group had the same result (the rate was 3.33%). There was no difference between these two groups.Conclusions The rate of recurrent intrauterine adhesions is no different between the control group of only use therapy of uterine adhesions and replacement of Foley balloon combining with therapy of uterine adhesions as intervention.

Objective To provide an information monitoring software for therapy drug,which can automatically construct safe concentration scope,statistically analyses data,query and input data.Methods TDMIS is developed by Powerbuilder 9.0 and is run in WIN 98 or the copy over it.2062 cases are analyzed through TDMIS and a safe concentration scope is set.Conclusion TDMIS is a practical software.It can make drug prescription standardized,computerized and easy to be statistically analyzed.The working efficiency and quality of clinical apothecary are greatly improved.

Objective]To explore the experiences in syndrome differentiation and treatment of acute leukemia from chief physician Xia Xiaojun. [Metheod] Learning my teacher diagnosing the disease, I refer to literature and combine with the study to summarize and introduce my teacher's clinical experiences and academic point of view in treatment of acute leukemia from the etiology and pathogenesis, syndrome differentiation, treatment, prescriptions and so on. [Results]Teacher Xia thinks that the emphasis of acute leukemia is deficiency in origin and excess in superficiality.The treatment is replenishing qi and blood,enforcing spleen and nourishing kidney and detoxication and activating blood stasis.Weighing the illness samples priorities and distinguishing between primary and secondary so as to improve the curative effect.[Conclusion]Teacher Xia bases on the progress of acute leukemia in different stages of syndrome characteristics,combines traditional Chinese with western medicine and finds the Huisheng Decoction series hebal medicine for treatment according to syndrome differentiation.The clinical curative effect is remarkable and the knowledge is worthy of our further in-deep learning.