Female ; Humans ; Melanosis ; Middle Aged ; Occupational Diseases

AIM: To explore the machanism of calcined mica by comparing the difference in crystal structure and inorganic elements of raw mica and calcined ones. METHODS: Crystal structures were compared by IR spectrum and X-ray crystallography and the contents of element in the prevention were determined with ICP-AES. RESULTS: After being calcined,crystal phase transformation changed in gold mica and did not change in white mica.Both of their chemical composition changed,crystal water decreased and crystal defects increased.There were obvious differences in the contents of inorganic elements.The content in white mica was obviously more than that in gold mica.After being calcined,the value of K/Na in white mica decreased and the contents of Ca,Mg increased,while the content of Mg increased and the content of Ca decreased in gold mica. CONCLUSION: There are(actually) many differences in contents of elements and chemical structure in white and gold mica before and after being calcined,which may explain the mechanism of calcined mica.

AIM: To study the technological parameters of the enrichmentpurification of iridoid glycoside with SP825-macroporous resin and method of increasing the content of morroniside and loganin in solid production. METHODS:()The sample volume,elution concentration,volume and methods were observed and compared with those elution solvents.The enrichment of iridoid glycosides was evaluated with contents of morroniside and loganin by HPLC methods. RESULTS: The optimum process was that sample of 2 times macroporous resin was absorbed two dynamicaly with columns of SP825macroporous resin and the column was washed with 7 column volume of 50% ethanol. CONCLUSION: After being enriched,the content of morroniside and loganin is raised 6 times and reached 69.68% in solid production.Iridiod glycoside are enriched by SP825-macroporous.It is a feasible method to produce preparation.

The paper discusses the problems and inequity in town and country family-planning service by comparing the following aspects: work thinking in the service,accessibility of family-planning service,service capacity of the organizations,resource allocation.Besides,in order to satisfy the demand of rural family-planning service market and improve the equity,some suggestions,such as integrating resource and complementing advantages to implement regional family-planning program,identifying the functions of government and changing the service thinking,increasing the investment in primary health family-planning organizations and reinforcing the co-operation between health and family-planning organizations.

We have made an investigation on medica1 college students' thinking about the teaching of human parasitology,and put forward a preliminary tentative plan and suggestion to the teaching goal,teaching content,method and so on to human parasitology teaching.

Objective To discuss the possibility of prognosing the hydatidiform mole deterioration and metastasis by detecting the expression of matrix metalloproteinase 9(MMP-9)in different type of trophoblastic disease,and analyze the correlative factors of the hydatidiform mole deterioration,so as to improve the criterion of hydatidiform mole prognosis.Methods The expression of MMP-9 in 30 cases of normal human(Iess than 12 weeks)cytotrophoblast cells,32 cases of partial hydatidiform mole,93 cases of complete hydatidiform mole,30 cages of invasive mole and 5 cases of choriocarcinoma were detected by immunohistochemical streptavidin-pemxidase.The factors as the age of onset,uterine size,luteinizing cyst,β-human chorionic gonadotropin hCG of 7 cases of the hydatidiform mole deterioration were analyzed.Results The expression of MMP-9 was detected in all types of trophoblastic cells,with the development of the malignant transformation the stainning Was markedly increased in the invasion of the normal human cytotrophoblast cells(X2=23.49,P＜0.05).Conclusion The difference of MMP-9 expressin gestational trophoblasts is helpful to predict the hydatidiform mole deterioration and metastagis,the hydatidiform mole deterioration correlates with the age of onset,β-hCG,uterine size,luteinizing cyst.

Coal ; Noise, Occupational ; prevention & control ; Steel

ObjectiveTo investigate whether miR-25 targets KLF4 to regulate the growth of gastric cancer cells and lucidate the mechanism of miR-25 producing functional effects in gastric cancer cells. Methods The expression levels of miR-25 and KLF4 were detected by qRT-PCR in 35 pairs of gastric cancer tissues of patients. Target genes of miR-25 were predicted using Targetscan and verified though dual luciferase activity assay and west-ern blot. MTT assay and clone formation assay were detected after downregulated miR-25 and overexpressed KLF4 respectively. Results miR-25 was highly expressed in gastric cancer tissues with KLF4 downexpresstion. Downreg-ulated miR-25 and overexpressed KLF4 respectively can significantly reduce the proliferation of gastric cancer cells,the results were opposite when overexpression of KLF4. Conclusion miR-25 promotes gastric cancer cells proliferation by targeting KLF4.

Objective To investigate essentiality of bone scintigraphy in patients with renal cellcarcinoma.Methods The clinical data of 152 patients with confirmed renal cell carcinoma from Jan uary 1999 to June 2007 were retrospectively analyzed.There were 106 men and 46 women with a meanage of 56 years (range 11-86 years).The tumor size was 1.5-20.0 cm (mean 6.0 cm).Accordingto the TNM and AJCC staging classification,88 patients had stage I,included of T1a in 47 cases,T1bin 41; 38 had stage Ⅱ; 16 had stage Ⅲ,included of T3a,in 10 cases,T3b in 6; and 10 had stage Ⅳ.Histological grade was well differentiated in 90 cases,moderately in 43,poor in 19.Ten clinical pa thology factors were evaluated by Logistic analysis to present the significant factors related to osseousmetastatic lesions.Results Overall osseous metastatic lesions were present in 22 of the 152 patients(14.5%).Of the 126 patients with clinically localized,11 cases (8.7%) had osseous metastatic le sions.Of the 16 patients with clinically advanced,5 eases (31.2%) had osseous metastatic lesions.Ofthe 10 patients with metastasis,6 cases(60%) had osseous metastatic lesions.Clinical stage was re lated to osseous metastatic lesions by Logistic analysis.The incidence of osseous metastatic lesionswas 40.9% in localized renal cell carcinoma patients with bone pain.Conclusions Bone seintigraphymay be omitted in patients with clinically localized renal ceil carcinoma(stage Ⅰ,Ⅱ) unless bone pain is pres ent.Bone scintigraphy should be performed in patients with stage Ⅲ or Ⅳ regardless of symptoms.

Objective To study the clinical significance of dexamethasone (DT) in the combined spinal and epidural anesthesia for delivery of elderly parturient women. Methods 134 elderly parturient women were selected as the research object, and randomly divided into two groups. 69 cases in DT group received intramuscular injection of dexamethasone and combined anesthesia, while 65 cases in INN group received intramuscular injection of tramadol (INN) and combined spinal and epidural anesthesia. The anesthetic effect of the two groups were observed. Results After treatment, the interleukin (IL-6), myeloperoxidase (MPO), tumor necrosis factor-α (TNF-α) and methane dicarboxylic aldehyde (MDA) in DT group were significantly higher than INN group (P<0.05). The five kinds of immunoglobulins levels (IgA, IgD, IgE, IgG and IgM) in DT group were higher than those in INN group (P<0.05). The heart rate (HR) in DT group was lower and mean arterial pressure (MAP) was higher than that in INN group(P<0.05). There was 1 cases of macrosomia, 2 cases of premature delivery in DT group, the adverse pregnancy outcomes was 4.35%(3/69). there was 1 cases of macrosomia, 1 cases of congenital deformity, 1 cases of premature delivery and 1 case of postterm delivery in DT group, the adverse pregnancy outcomes was 5.80%(4/69), with no significant difference between two groups. Conclusion Dexamethasone combined with anesthesia is very effective for delivery of elderly parturient women which shows very good anti-inflammatory and immunoregulation.