Pancreatic cancer is one of the most malignant gastrointestinal tumors,characterized by a poor prognosis,absence of specific clinical symptoms and signs,prone to metastases and lack of response to conventional therapy.1 year survival rate of this disease increased to about 20 ％ by gemcitabine,but the morbidity and mortality rates are still higher and higher in the whole worldwide.DNA methylation is one of the mechanisms of epigenetics which is the study of heritable changes in gene expression that are not coded in the DNA sequence itself.It seems that DNA methylation indeed plays an important role in the development and progression of pancreatic cancer.

Newborns,especially premature newborns,because of immature of immune function,have high incidence of sepsis.Today sepsis is still an important cause of neonatal death and poor prognosis.Unfortunately,clinical signs of sepsis are non-specific,so early diagnosis and treatment of the newborn infant with suspected sepsis are essential to prevent severe complications.Blood culture is the gold standard for diagnosis of sepsis,but the positive rote is low.Indicators in diagnosis of sepsis included acute phase reaction proteins,cytokines,cell surface antigen and bacterial DNA testing.This article compares and analyzes the indicators in diagnosis of neonatal sepsis.

Objective To observe effect of Rho kinase inhibitor combined with hyperbaric oxygen on the recovery of neurological function after spinal cord injury in patients with thoracolumbar fractures.Methods A total of 80 cases of thoracolumbar fractures combined with spinal cord injury patients as the research object, the packet by the standards of admission of single and double serial number, odd numbers were divided into control group, even number were divided into treatment group (40 cases in each group); two groups underwent surgical treatment, control group was given single usage fasudil treatment, treatment group was given hyperbaric oxygen therapy for auxiliary therapy on the basis of control group, Continuous treatment for two months.Compared neurological function scoring, grading, blood superoxide dismutase (SOD) , epithelial growth factor (EGF) , lipid peroxide (LPO) and adverse reactions pre-and post-treatment between two groups of patients.Results After treatment,total effective rate of treatment group (92.50%), ASIA sensory, movement scores were significantly higher than control group (75.00%)(P<0.05);Content of SOD and EGF of treatment group were significantly higher than control group(P<0.05);the adverse reaction rate (12.50%) was significantly lower than that of control group (32.50%)(P<0.05).Conclusion Rho kinase inhibitor combined with hyperbaric oxygen can significantly improve the degree of injury, neurological function and blood SOD, EGF, LPO content in patients with lumbar vertebral fractures combined with spinal cord injury, and the adverse reactions are few, has definite clinical effect.

The main goal for the foundation of national life science and technology talents cultivating base(biopharmaceutical base) is building up perfect talents education systems to create elites with originality and carving-out ability.4 aspects including optimizing courses?improving teaching technics?enhancing practicing ability and reforming pattern of running school were mentioned to explore the cultivating system of biopharmaceutical base.

Objective To study the effect of lidocaine combined with local anesthesia and psychological intervention in induced abortion.Methods200 cases of artificial abortion in our hospital from March 2015 to August 2016 were selected as the research object and randomly divided into control group and experimental group,with 100 cases in each group.The control group was treated with lidocaine for local anesthesia,direct abortion,and the experimental group was given lidocaine local anesthesia and psychological intervention.The pain and satisfaction index of the two groups were compared.ResultsAfter the treatment, the satisfaction rate of cervical dilatation in the experimental group was 93 cases was 93% higher than that in the control group, and the difference was statistically significant (P<0.05).The number of patients with grade Ⅱ pain in the experimental group was 12, and the number of patients with grade I pain was 87.In the control group, the number of patients with grade Ⅱ pain was 25, and the number of patients with grade Ⅱ pain was 57.But the control group was significantly lower than the experimental group, with statistical difference (P<0.05).In the control group, patients with grade Ⅱ pain were significantly higher than those in the experimental group, the number of patients with grade I pain was significantly less than that in the experimental group, and the difference was statistically significant (P<0.05).There was no significant difference in the operation time and blood loss between the control experimental and the control group.ConclusionThe application of lidocaine local anesthesia combined with psychological intervention can effectively relieve the pain of patients and improve the therapeutic effect.It has the value of clinical popularization and Application.

Objective To explore the influence of behaviour.individuality-personality factors on the intellectual impairment in early period of cerebral infarct.Methods To compare the correlation of the occurence of intellectual impairment and behaviour individuality among 98 cerebral infarct dementia index cases and 80 cerebral infarct without dementia index cases and 87 control subjects.Results A-type behaviour have 63.27％ cerebrol infarct dementia index cases,47.75％ cerebrol infarct without dementia inedx cases,and 35.63％ control subjects.(EPQ)P >60,63.2％ cerebral infarcl domentia index cases,35％ cerebrol infarct without demcntia index cases,and 20.69％ control subjects.(EPO)N>55,42.86％ cerebrol infaret demcntia index cases,38.75％ cerebrol infarct without dementia index cases and 24.14％ control subjects. Conclusion A type behaviour play on important role on intelligence impairment in post cerebral infact.Psychone drviduality and unsteady mood were manly mood feature of cerebral infarct,especially important post cerebral infarct intelligence impairment.

Objective To realize the clinical and epidemiological characteristics of measles,and explore effective measures to control measles epidemic.Methods Clinical data of 554 hospitalized measles children between January 2009 and December 2013 were analyzed retrospectively.Results All children had fever,cough,and skin rash,507 (91.52% )had typical clinical manifestations of measles,47(8.48% )had mild manifestations;the major population were children aged≤6 months(n= 176,31.77% )and 7-8 months (n= 346,62.45% );132 (23.83% )children had contact history of confirmed measles,19(3.43% )measles children’s mothers also developed measles (all were cases of 2013),227 (40.97% )children had history of repeated infusion or hospitalization in large medical institutes dur-ing the measles incubation period (all were cases of 2013,there were measles children who had infusion or hospitali-zation in the same hospital during the same period). The peak incidence of measles usually occurs in January-May. Conclusion Intensive immunization of measles for young women of reproductive age and vaccination with“pre-mea-sles vaccine”for early infancy,and strengthening the medical management of fever outpatients are important meas-ures to prevent measles epidemic.

The arteries of the M. latissimus dorsi, gracilis, tensor fasciae latae, gastrocncmius and soleus were studied on 100 Chinese cadavers (40 fetus and babies, 60 adults) by dissection and arteriography. The origin, number, diameter and distribution of these arteries were observed, and were investigated quantitatively by means of MAGISCAN-Ⅰ Image Analyser.Based on the studies of the vascular anatomy of muscles. We classified the arterial distribution into three patterns: Type Ⅰ: The muscle of this group was supplied by one or two main arteries which coursed the entire muscle belly, as in: M. tensor fasciae latae, gastrocnemius, soleus. Type Ⅱ: The muscle of this group had a segmental supply of several arteries, which is distributed partially in muscle belly, as in: M. gracilis, soleus. Type Ⅲ: The musele of this group had a combination of both patterns of vascular arrangement, as in: M. latissimus dorsi, soleus.The muscles of Type Ⅰ and Type Ⅱ could often be divided into several regions which were based on the distribution of each branch of the artery.

Objective To get the information about the infection condition of blood in voluntary donors in Fuling District from 2001 to 2007, so as to take measures to improve blood quality and ensure blood safety.Methods Serum ALT was detected with Reitman-Frankel assay, and HBsAg, anti-HCV, anti-HIV and anti-TP were detected with ELISA.Results A total of 72 868 serum samples from blood donors were detected, in which 5 512 (7.56%) were positive. The positive rates of HBsAg, anti-HCV, anti-HIV and anti-TP were 3.09%, 0.48%, 0.07% and 1.27% respectively, and the abnormality rate of ALT was 2.73%. There was statistical difference of positive rate among various years (from 2001 to 2007).Conclusion The positive rate of blood in voluntary donors decreases year by year. HBsAg was the highest (1.16%), followed by ALT (2.73%), anti-TP (1.27%), anti-HCV and anti-HIV. It suggests that blood quality monitoring should be strengthed to assure blood safety.

Papers on medical information system published in 16 medical journals in 2013 JCR with their IF≥1 were retrieved from Web of Science(2010-2014).Social network analysis and co-word analysis of their high fre-quency key words showed that efficiency of medical information system implementation, acceptance behaviors of medical information system users, mining of medical data, application of medical information system in medical sci-ences, and application of decision support system in medical sciences were the hotspots in papers on medical infor-mation system.The authors pointed out that electronic health records, medical information system management, and application of emerging information technology in medical information system were still the study hotspots in the coming years.