Pancreatic cancer is one of the most malignant gastrointestinal tumors,characterized by a poor prognosis,absence of specific clinical symptoms and signs,prone to metastases and lack of response to conventional therapy.1 year survival rate of this disease increased to about 20 ％ by gemcitabine,but the morbidity and mortality rates are still higher and higher in the whole worldwide.DNA methylation is one of the mechanisms of epigenetics which is the study of heritable changes in gene expression that are not coded in the DNA sequence itself.It seems that DNA methylation indeed plays an important role in the development and progression of pancreatic cancer.

Newborns,especially premature newborns,because of immature of immune function,have high incidence of sepsis.Today sepsis is still an important cause of neonatal death and poor prognosis.Unfortunately,clinical signs of sepsis are non-specific,so early diagnosis and treatment of the newborn infant with suspected sepsis are essential to prevent severe complications.Blood culture is the gold standard for diagnosis of sepsis,but the positive rote is low.Indicators in diagnosis of sepsis included acute phase reaction proteins,cytokines,cell surface antigen and bacterial DNA testing.This article compares and analyzes the indicators in diagnosis of neonatal sepsis.

Bronchopulmonary dysplasia is one of the most common chronic respiratory diseases in premature infants, especially in very low birth weight infants.Lung immaturity, inflammatory injury, oxidative stress and abnormal repair after injury are the important factors.Leukotriene is an inflammatory mediator of 5-lipoxygenase pathway and participates in the occurrence of bronchopulmonary dysplasia.Montelukast, as a leukotriene receptor antagonist, may play a role in the treatment of bronchopulmonary dysplasia through anti-inflammation, anti-oxidation and anti-fibrosis.This article will review the potential mechanism and related clinical researches of montelukast which is used in treating bronchopulmonary dysplasia.

Objective To explore the influence of behaviour.individuality-personality factors on the intellectual impairment in early period of cerebral infarct.Methods To compare the correlation of the occurence of intellectual impairment and behaviour individuality among 98 cerebral infarct dementia index cases and 80 cerebral infarct without dementia index cases and 87 control subjects.Results A-type behaviour have 63.27％ cerebrol infarct dementia index cases,47.75％ cerebrol infarct without dementia inedx cases,and 35.63％ control subjects.(EPQ)P >60,63.2％ cerebral infarcl domentia index cases,35％ cerebrol infarct without demcntia index cases,and 20.69％ control subjects.(EPO)N>55,42.86％ cerebrol infaret demcntia index cases,38.75％ cerebrol infarct without dementia index cases and 24.14％ control subjects. Conclusion A type behaviour play on important role on intelligence impairment in post cerebral infact.Psychone drviduality and unsteady mood were manly mood feature of cerebral infarct,especially important post cerebral infarct intelligence impairment.

Therapeutic effect of pancreatic cancer depends on early detection and effective treatment.The early diagnosis of pancreatic cancer is so difficult that the discovery of pancreatic cancer is often in mid and late stages,so the treatment of meaning is not so satisfying.In recent years the rapid study of proteomics has brought great hope in the early discovery of pancreatic cancer to make it the post-genome era of functional genomics research in hot areas.Separating and identifying the serum、juice and tissue of patients with pancreatic cancer to find out the different proteins between normal and sick individuals can provide theoretical base and new ideas for the pathogenesis and early diagnosis of pancreatic cancer.

Objective To explore the efficacy of flupenthixol melitracen in the treatment of functional dyspepsia (FD) and its effects on receptivity expansion and visceral sensitivity.Methods A randomized,controlled,multi-centre study was carried out.The FD patients with depression were divided into anti-depression group and control group.The patients of both groups received omeprazole and mosapride treatment for eight weeks.The patients of anti-depression group added flupenthixol melitracen and psychotherapy.Before the treatment,by the end of the second,fourth,sixth and eighth week of the treatment,the scores of upper gastrointestinal symptoms and adverse effects of the patients of the two groups were recorded,the psychological status was evaluated by Hamilton depression scale and the gastric receptivity expansion and visceral sensitivity were assessed by water loading test (WLT).The data were analyzed by t test and chi-square test.Results Among two hundred and fifty enrolled FD patients with depression,245 patients (129 in anti-depression group,116 in control group) were enrolled in intention-to treat analysis.Before the treatment and by the end of the eighth week of the treatment,the scores of upper gastrointestinal symptoms of anti depression group were 12.23±4.45 and 2.31±2.13 (t=22.837,P=0.008),the control group were 12.29± 4.62 and 8.58±3.76 (t=6.708,P=0.184).By the end of the eighth week of treatment,the difference between the two groups was statistically significant (t =16.261,P＜0.05).By the end of the fourth and eighth week of treatment,the total effective rates of the improvement of upper gastrointestinal symptoms of anti-depression group were 76.0％ (98/129) and 83.7％ (108/129),control group were 14.7 ％ (17/116) and 25.9 ％ (30/116),the differences between the two groups were statistically significant (x2 =92.191 and 83.117,both P＜0.05).By the end of the eighth week of treatment,the total effective rate of the improvement of depression of anti depression group was 71.3％ (92/129),which was higher than that of control group (23.3％,27/116),the difference between two groups was statistically significant (x2 54.434,P＜0.01).Before the treatment,the maximum WLT volume of anti depression group was (850±130) mL,by the end of the eighth week of treatment was (1400±210) mL (t=25.292,P＜0.01).Before the treatment and by the end of the eighth week of treatment,the maximum WLT volumes of control group were (800± 120) mL and (960±140) mL (t=9.345,P＜0.01).All the adverse effects of anti depression therapy were mild.Conclusion The treatment of flupenthixol melitracen can improve the efficacy in patients with FD,relieve the depression status,improve gastric receptivity expansion and visceral sensitivity with a good safety and tolerability.

Objective To realize the clinical and epidemiological characteristics of measles,and explore effective measures to control measles epidemic.Methods Clinical data of 554 hospitalized measles children between January 2009 and December 2013 were analyzed retrospectively.Results All children had fever,cough,and skin rash,507 (91.52% )had typical clinical manifestations of measles,47(8.48% )had mild manifestations;the major population were children aged≤6 months(n= 176,31.77% )and 7-8 months (n= 346,62.45% );132 (23.83% )children had contact history of confirmed measles,19(3.43% )measles children’s mothers also developed measles (all were cases of 2013),227 (40.97% )children had history of repeated infusion or hospitalization in large medical institutes dur-ing the measles incubation period (all were cases of 2013,there were measles children who had infusion or hospitali-zation in the same hospital during the same period). The peak incidence of measles usually occurs in January-May. Conclusion Intensive immunization of measles for young women of reproductive age and vaccination with“pre-mea-sles vaccine”for early infancy,and strengthening the medical management of fever outpatients are important meas-ures to prevent measles epidemic.

The previous studies identify connexin as a tumor suppressor gene,which inhibits the occurrence and development of breast cancer.However,some researches of resent years demonstrate that the expression level of connexin in a large part of metastatic breast cancer is elevated and connexin may promote breast cancer metastasis.Therefore,connexin may play different roles by different mechanisms in the occurrence,development,invasion and metastasis of breast cancer.Rational use of connexin in breast cancer treatment can be beneficial to breast cancer patients.

The immunohistochemical staining showed the connexin 43 (Cx43) was strongly expressed (average gray value, AGV=230±5), distributed at junction area and intercalated disks of cardiocytes in normal rats,and much less expressed (AGV 193±4) (P<0.01) and distribution-disorganized in STZ-induced diabetic rats. This may be associated with the pathogenesis of diabetic myocardial lesions.

Objective To investigate the effect of ectopic pregnancy tubal resection or common disease retention on female reproductive endocrine and menstrual traits.Methods 286 patients with ectopic pregnancy lapa-roscopic operation were selected.According to the different treatment methods,the patients were divided into resection group (n =199),retention group 87 cases,in surgical operation on the third day and the thirtieth day and tested for female reproductive hormone (P,LH,FSH,E2 )and human chorionic gonadotropin (hCG).Results Resection group in the third day after surgery of FSH[(8.5 ±4.9)IU /mL]was significantly higher than that of preserving group[(3.9 ± 0.9)IU /mL],with significant difference (t =5.44,P <0.05),the amounts of LH,E2 ,P and HCG were insignificant (t =0.56,1.24,0.82,all P >0.05).30 days after the surgery,there was no significant difference between the two groups in FSH,LH,E2 ,P and HCG (t =0.92,0.77,1.02,0.65,all P >0.05),but at the age of more than 40 years old and bilateral absence of fallopian tube in patients with,menorrhagia and menstrual cycle change obviously,and female ovarian endocrine function to reduce the clinical symptoms.Conclusion Tube resection has some influence on the ovarian function of tubal ectopic pregnancy,especially older,lack of bilateral fallopian tube.