Objective To study the reasons why PLoS One has set off an upsurge in China especially in hospitals, the academic level of papers published in PLoS One, and how to correctly judge the SCI-covered papers published by hospitals.Methods Papers published in PLoS One by hospitals in China were retrieved.The number of papers published in PLoS One by hospitals in China, the institutions that published the papers in PLoS One, and the num-ber of fund-supported papers were analyzed.Results A total of 9739 papers were published in PLoS One by hospitals in China from 2007 to October 2015, with an average cited frequency of 5.29.The majority of authors who published the papers were from affiliated hospitals of scientific research institutions and teaching hospitals of colleges and uni-versities.Of the 9739 papers, 87.78%were supported by funds from different foundations.Conclusion Nothing is strike about the academic level of papers published in PLoS One by hospitals in China with their average cited fre-quency lower than that (8.14) in our country.The SCI-covered papers published by hospitals should not be con-sidered as the only criterion in assessing the performances of staff in hospitals.

目的观察急性心肌梗死患者早期康复护理的远期效果。方法40例老年急性心肌梗死患者随机分为实验组20例(早期康复组)和对照组20例(常规治疗组),前者接受2周的康复护理,后者接受3周的康复护理。对两组患者进行为期18个月的随访,观察其心功能、活动情况,及心绞痛和再梗死的发生率。结果两组患者的心功能无明显差异,但实验组患者心绞痛的次数和再梗死的发生率低于对照组(P<0.05)。结论对急性心肌梗死患者进行早期康复是安全、可行的,可改善心功能和降低再梗死的发生率,减少并发症的发生。

Female ; Humans ; Melanosis ; Middle Aged ; Occupational Diseases

Congenital long QT syndrome ( LQTS) is a cardiac ion channel dysfunction, leading to prolonged myocardial repolarization time. It is characterized by the typical ECG QT interval prolongation and torsades de pointes. It shows clinical recurrence of cardiogenic syncope and even lead to sudden death. Molecular genetic studies have revealed a total of 12 forms of congenital LQTS caused by mutations in genes of the potassium, sodium and calcium channels or membrane adapter located on chromosomes 3, 4, 7, 11, 12, 17, 20 and 21. This review summarized the studies of the pathogenesis of LQTS and gene-related treatments.

Objective To investigate the regularity and characteristic of adverse drug reaction (ADR).Method 987 ADR cases collected in our hospital from 2005 to2010 were analysed statistically.Results Numbers of ADR reports increased quickly.The incidence of new and severe ADR increased every year.Numbers of ADR reports written by nurses and pharmacists increased every year.The incidence of ADR in female was higher than in male.Antimicrobials showed the highest proportion (76.46％) among all kinds of drugs which were involved in these ADR cases.Among all antimicrobials,penicilins which advanced cephalosporins and quinolones showed the highest proportion.83.49％ which were largest were caused by intravenous administration.Main clinical manifestation were lesion of skin and its appendants (44.66％).Conclusion Publicity and training of ADR knowledge,ADR monitoring and rational drug use should be strengthened in order to use drug safely.

Neutrophil genatinase-association lipocalin(NGAL)is a kind of lipocalin of binding proteins that seems to be a popular topic studied much recently,which at first was considered as endogenous bacteriostatic agent.It is bound up with the occurrence,development and prognosis of many kidney diseases.Therefore,it can provide new idea and method on clinical diagnosis and treatment by further study on expression and significance of NGAL in kidney diseases.

Depressive disorders are very common in older people.Most of the patients suffered from depressive disorders seek help from non-mental health professional in general hospitals.To help physicians in general hospitals to recognize and treat depressive disorders in the elderly,a case report on unrelieved chest pain after coronary artery stents is presented in this paper,and then clinical manifestation, diagnostic criteria, clinical assessment, principles for antidepressants and psychotherapies to alleviate depressive symptoms are introduced.

Objective To investigate the clinical characteristics and prognosis of young patients with endometrial cancer.Methods Thirty cases with endometrial cancer were selected as our observed group (age less than 40 years old).Forty cases with endometrial cancer were selected as control group and their age were over 40 years old.The information about clinical characteristics,diagnosis,treatment and prognosis of patients in two groups were collected.Results The rates of primary infertility and less than 3 times of pregnancy in observed group were 30.0％ (9/30),56.7％ (17/30) respectively,higher than that in control group (5.0％(2/40) or 30.0％ (12/40)).The differences were statistically significant (x2 =6.183,5.372 respectively,P ＜ 0.05).The positive rate of estrogen receptor(ER) and progesterone receptor(PR) expression were 93.3％ (28/30) and 86.7％ (26/30) in observed group,higher than that in control(42.5％ (17/40),52.5％ (21/40)respectively).The differences were statistically significant (x2 =5.951,4.721 respectively,P ＜ 0.05).Two groups of patients were statistically significant differences in pathological stage,the pathological type of observed group was mainly stage Ⅰ (76.7％ (23/30)),higher than that of control group (47.5 (19/40),and the difference was statistically significant (x2 =5.464,P ＜ 0.05).There was statistically significant difference between the observed and control group on Cervical infiltration and lymph node metastasis(x2 =5.464,1.018respectively,P ＜ 0.05).Conclusion The infeaility and less than 3 times of pregnancy may be the risk factors of younger endometrial cancer and the pathological type of observed group was mainly stage Ⅰ.However the prognosis is similar between the young and the old patients.

Objective To investigate the chnical effect of levonorgestrel-releasing intrauterine system(LNG-IUS) in patients with adenomyosis.Methods A total of eighty patients with adenomyosis were enrolled and underwent LNG-IUS insertion.The degree of dysmenorrhea,amount of menorrhea,size of the uterus,endometrial thickness,hemoglobin as well as hormonal changes and adverse reaction before treatment and after treatment for 3,6,12 months were compared.Results After treatment for3,6,12months,the amount of menorrhea was reduced [(52.4 ± 8.4)％,(22.6 ± 9.8)％,(14.8 ± 8.6)％ vs.(100.0 ±0.0)％],the scores of dysmenorrhea was reduced [(1.2 ± 0.5),(0.8 ± 0.4),(0.3 ± 0.2) scores vs.(2.4 ±0.6) scores],the level of hemoglobin was increased [(104.4 ± 11.4),(109.2 ± 12.6),(118.8 ± 13.4) g/L vs.(88.6 ± 16.5) g/L],the endometrial thickness was thinner [(6.3 ± 1.4),(3.6 ± 0.8),(1.8 ± 0.5) mm vs.(9.2 ± 2.8) mm],the size of the uterus was reduced [(156.8 ± 56.8),(142.4 ± 48.9),(126.6 ± 36.5)cm3 vs.(172.6 ± 62.5) cm3],there was significant difference compared with that before treatment (P ＜ 0.05).After treatment for 3,6,12 months,the levels of folhcle-stimulating hormone,luteinizing hormone and estradiol had no significant difference compared with those before treatment (P ＞ 0.05).After treatment for 3,6,12 months,the level of cancer antigen 125 was significantly reduced compared with that before treatment [(34.6 ± 11.6),(16.6 ± 9.8),(11.7 ± 6.4) kU/L vs.(62.4 ± 24.3) kU/L].Conclusiom The LNG-IUS has exact therapeutic effect in treatment of adenomyosis,and has little influence on ovarian function.It is worth of using in clinic.

Objective To explore the clinical efficacy of ethinylestradiol and cyproterone acetate (Diane-35) combined with mefformin in patients with polycystic ovary syndrome (PCOS).Methods One hundred and sixty patients with PCOS were divided into control group and observation group by random digits table method with 80 cases each.Patients in the control group were given Diane-35 only,while patients in the observation group were given Diane-35 combined with metformin.The triglycerides (TG),total cholesterol (TC),low density lipoprotein cholesterol (LDL-C),fasting insulin (FINS),fasting blood glucose (FBG),follicle-stimulating hormone (FSH),luteinizing hormone (LH) and testosterone (T) of patients in the two groups were measured before treatment and after treatment 6 months,the rates of pregnancy and abortion were recorded.Results TC,LDL-C,FINS,FBG,FSH,LHt and T of both the 2 groups after treatment decreased obviously than before treatment,and TG in observation group decreased obviously than before treatment,there were statistical differences (P ＜ 0.05).There was no statistical difference in TG in control group between before treatment and after treatment (P ＞ 0.05).After treatment,TG,FINS,FBG,LH in observation group were lower than those in control group [(1.0 ± 0.2) mmol/L vs.(1.6 ± 0.8) mmol/L,(15.2 ± 6.3) mU/L vs.(18.9 ± 6.2) mU/L,(4.5 ± 1.1) mmol/L vs.(5.1 ± 0.9) mmol/L,(6.3 ± 3.0) U/L vs.(7.4 ± 2.9) U/L],there were statistical differences (P ＜ 0.05).After treatment,the rate of pregnancy in observation group was higher than that in control group [61.2％(49/80) vs.42.5％(34/80)],there was statistical difference (x2 =5.633,P＜ 0.05).The rote of abortion in observation group was lower than that in control group [6.1％(3/49) vs.17.6％(6/34)],but there was no statistical difference (x2 =1.694,P ＞ 0.05).Conclusion The clinical effect of Diane-35 combined with metformin in patients with PCOS is better than Diane-35 only.