Objective To explore college students'achievement motivation level at basic medical education stage and its influencing factors.Method Achievement motivation scale and open questionnaire were applied in 223 college students at basic medical education stage.The effect of multiple influential factors on achievement motivation was analyzed from the perspectives of pursing for success and avoiding errors by multiple linear regression.Results The results showed that 70.4％ students had low achievement motivation level.Multiple factors had linear regression relation with Ms and Mf(RMs=0.644,RMf=0.898).Academic self assessment and learning attitude can increase the motivation for success significantly(P＜0.001).Performance evaluation and learning objective can significantly increase the motivation for avoiding errors(P＜0.001).Conclusion The study and application of achievement motivation can improve education quality at basic medical education stage.

As the newest anti-vascular endothelial grown factor (VEGF) drug,alfibercept binds to all forms of VEGF-A,VEGF-B, and PIGF.So far, intravitreal injection of alfibercept has already been used to treat certain opthalmological diseases, such as neovascular age-related macular degeneration, polypoidal choroidal vasculopathy, central retinal vascular occlusion, diabetic macular edema, corneal neovascular,and retinopathy of prematurity.In this article,we contrasted alfibercept to the other anti-VEGF drugs, conducted a review of the recent research progress of alfibercept in opthalmological diseases and introduced the questions which still need to be solved and the probably research direction of alfibercept in the future.

Setting Chinese as preparatory courses is an effective way to harmonize Chinese language teaching and medical teaching.By this way,some low-level students can be disqualified from further study,thus both the level of Chinese teaching and medical professional teaching can be improved.In the process of the eductional system reform from 5 years to 6 years,building Chinese training based preparatory course,will consummate the oversea medical undergrade education system.

Genotype ; Hepatitis B, Chronic ; complications ; Hepatitis C, Chronic ; complications ; Humans ; Parvoviridae Infections ; complications ; virology ; Parvovirus ; classification ; genetics ; isolation & purification ; Parvovirus B19, Human ; isolation & purification

Objective To investigate the influence of early rehabilitation on cognitive function of patients with acute stroke.Methods 120 acute stroke patients were selected as research subjects,and according to the digital table,they were randomly divided into the study group and the control group.ESS,BI,QOF and NCSE Scale were used to evaluate the limb function,quality of life,cognitive function of patients before and after treatment.Results After treatment,ESS score was higher than before treatment.After treatment,ESS score of the study group was (81.4 ±7.7) points,which was significantly higher than the control group (75.1 ± 4.5) points (t =5.47,P ＜ 0.05).BI,QOF score after treatment were higher than before treatment.BI,QOF score in the study group were (67.3 ± 16.7) points,(8.2 ± 0.4) points respectively,which were significantly higher than those of the control group [(58.2 ± 14.5) points,(7.6 ± 0.7) points] (t =3.19,5.77,all P ＜ 0.05).After treatment,the scores of cognitive function in the study group were significantly higher than those in the control group (t =4.21,7.33,4.77,2.86,7.48,4.06,7.11,4.92,7.23,4.11,all P ＜ 0.05).Conclusion Early rehabilitation treatment can improve the patients' neurological deficit,improve the patients' limb movement disorder and cognitive function,improve quality of life.

Objectives To explore the relationship of serum miR-30a and cardiac function in children with congenital heart disease (CHD), and the diagnostic value of serum miR-30a to heart failure. Methods From January 2013 to June 2013, 65 children with CHD were enrolled, and divided into the HF group (patients with heart failure, n=40) and the Non-HF group (patients without heart failure, n=25) according to modified Ross score. The serum miR-30a expression level was quantified by real-time PCR. Left ventricular ejection fraction (LVEF) was tested by echocardiography. The correlation between miR-30a and modified Ross score and LVEF were evaluated with Spearman's analysis. The area under the receiver-operating characteristic (ROC) curve for miR-30a was examined. Results The expression level of miR-30a in HF group was higher than that in Non-HF group, the LVEF was lower in HF group than that in Non-HF group (all P<0.001). The serum miR-30a level was positively correlated with modified Ross score (r=0.63, P<0.01) and negatively correlated with LVEF (r=-0.32, P<0.01). According to ROC analysis, the AUC of miR-30a for detection of HF was 0.7440. Conclusion The expression level of serum miR-30a was closely correlated with the cardiac function, which can be as a biomarker for indicating the heart failure in CHD.

Human breast milk contains a good balance of nutrients.In recent years,researchers have found that it contains not only abundant nutrients,but also different active components,and MicroRNAs (miRNA) are included.MiRNA are endogenous non-coding RNA,consisting of 21 to 25 nucleotides in length.They play an important role in regulating a variety of biological processes.In the miRNA confirmed in human breast milk,let-7、miRNA-30b and miRNA-378 are highly expressed and researches have already demonstrated that these miRNA are participating in the regulation of adipocytes differentiation,lipid accumulation and sugar and lipid metabolism.

After an analysis of the urgent need of systematic medical information service in village and township hospitals and doctors and the advantageous conditions for medical academic libraries to provide information service for them, its imple-mentation strategies were proposed and how to promote the construction of libraries and the development of medical cause in villages and townships by providing information service in countryside were pointed out.

10.3969/j.issn.2095-4344.2013.24.023

Lung cancer is one of the most common malignant tumors in the world.Non-small lung canc-er( NSCLC) accounts for approximately 85%,but its pathogenesis has not been elucidated.As a family of soluble enzymes,matrix metalloproteinases(MMPs)can degrade the constituents of the extracellular matrix(ECM)and the basement-membrane,members share common structural features and are responsible for the relative specific sub-strates.Some researches show that the matrix metalloproteinases 7(MMP-7)involve in the invasion and metasta-sis of NSCLC,the expression of MMP-7 in the tissue of NSCLC is significcantly higher than that in adjacent tis-sues,and the MMP-7 plays important roles in prognosis evaluation of NSCLC patients.Therefore this paper sum-marize the domain structure,function,regulation and research in NSCLC about MMP-7.