BACKGROUND:Precision attachment has been widely used in complete denture because of its strong retention, good appearance, comfort and durability. Among them, magnetic attachment and bal-cap attachment are commonly applied for mandibular complete denture.
OBJECTIVE:To compare the clinical effects of magnetic attachment, bal-cap attachment and traditional clasp retainer used in the mandibular removable partial denture.
METHODS:A total of 45 patients with dentition defects were included in this study, they were treated with magnetic attachment, bal-cap attachment and traditional clasp retention of mandibular removable partial denture. Fifteen patients received one means. The satisfaction of patients and the periodontal health of abutments were observed after 3 years.
RESULTS AND CONCLUSION:Comparison of the patient satisfaction showed that, the aesthetics, retention conditions, masticatory function and comfort in magnetic attachment group were significantly better than traditional clasp retention group (P<0.05). The aesthetics and comfort in bal-cap attachment group were also better than traditional clasp retention group (P<0.05). There were significant differences on the retention conditions and comfort between magnetic attachment group and bal-cap attachment group (P<0.05). Gingival index was the highest in magnetic attachment group, then in bal-cap attachment group, and the lowest in traditional clasp retention group (P<0.05). The abutment tooth mobility degree was the lowest in magnetic attachment group, then in bal-cap attachment group, and the highest in traditional clasp retention group (P<0.05). The periodontal pocket depth in magnetic attachment group and bal-cap attachment group was lower than that in traditional clasp retention group (P<0.05). The alveolar bone height was the highest in magnetic attachment group, then in bal-cap attachment group, and the lowest in traditional clasp retention group (P<0.05). Experimental findings indicate that, precision attachment over-denture retention superior to traditional clasp removable partial denture in mandibular denture repairing. Magnetic attachment can provide better retention power and better protect the health of periodontal tissue compared with bal-cap attachment.

The basic physiological function of anti-arrhythmic drugs is affects myocardial cell membrane ion channels. Change the ion flow and affect cell electrophysiological properties, change the conduction velocity, eliminate retrace, inhibit autorhythmicity and trigger events, inhibit the occurrence of arrhythmia, but will trigger a new activities, new retrace, produce new arrhythmia. In recent years, with the improvement of the theoretical system of traditional Chinese medicine and the production of new research methods, Chinese medicine treatment of arrhythmia has a new development. This article summarized the recent decades of which Chinese medicine monomer anti-arrhythmic drugs that had been proved by the influence of monomer anti-arrhythmic drugs, lists the differents traditional Chinese medicinal materials which chemical composition and the effective of the anti-arrhythmic effects, shows the unique advantages of Chinese medicine in the aspect of anti-arrhythmic, and points out that the current Chinese medicine in anti-arrhythmic (monomer) existing problems and solutions.
Anti-Arrhythmia Agents ; therapeutic use ; Arrhythmias, Cardiac ; drug therapy ; Biomedical Research ; Drugs, Chinese Herbal ; therapeutic use ; Humans

Sperm DNA fragmentation index (DFI) refers to the percentage of DNA strand breaks in the total sperm. Many studies suggest that elevated DFI can lead to male infertility and early spontaneous abortion. High-DFI patients are more likely to fail in assisted reproduction and preliminary treatment or prevention methods have been developed for this population. This review focuses on the impact of DFI on clinical pregnancy outcomes and progress in the studies of its treatment.
Abortion, Spontaneous ; Chromatin ; DNA Fragmentation ; Female ; Humans ; Infertility, Male ; Male ; Pregnancy ; Pregnancy Outcome ; Sperm Injections, Intracytoplasmic ; Spermatozoa

OBJECTIVE: To research and regulate the crystal quality of alanylglutamine for improving their stability and pharmacodynamics as well as vacuum freeze-drying efficiency. METHODS: Scanning electron microscopy (SEM), X-ray powder diffractometer (XRD), differential scanning calorimetry (DSC), and thermogravimetric analyzer (TG) as well as lyophilized experiments were used to investigate the effect of pre-freeze method on crystallinity and uniformity of particle size of alanylglutamine. RESULTS: The result of SEM revealed that the lyophilized alanylglutamine with accelerated pre-freeze method is small-size particle with low crystallinity. Then the lyophilized alanylglutamine with multi-step annealing pre-freeze method become uniformly large particle with high crystallinity. The RESULTS of XRD and DSC indicted that, comparing with the lyophilized alanylglutamine with accelerated pre-freeze method, the lyophilized sample with multi-step annealing pre-freeze method is easier to form the crystal medicine with uniform particle size, less crystal defects, high crystallinity. And the former has lower stability than the later. CONCLUSION: The final lyophilized experiment give us a CONCLUSION that using the multi-step annealing pre-freeze method can improve the freeze-drying efficiency and crystal quality of alanylglutamine, which to achieve the ultimate goal of cost and energy saving.

OBJECTIVETo investigate the exerted force in different phases of the female menstrual cycle, as well as the changes in estrogen (E2), osteocalcin (OCN), receptor activator of nuclear factor-kappa B ligand (RANKL), and osteoprotegerin (OPG) levels in the gingival crevicular fluid (GCF) during orthodontic tooth movement, to provide a theoretical basis for the selection of the best opportunity for efficient tooth movement.

METHODSTwelve women (aged 18 years to 28 years) with extracted first premolars had been selected. Six women in the group were randomly selected as the menstrual period group, whereas the remaining six were assigned to the ovulation period group. Right canines were retracted with 1.5 N NiTi close coil spring. GCF samples were collected prior to the force exertion experiments at 0 (T0), 15 (T1), 30 (T2), and 45 d (T3). The levels of E2, OCN, OPG and RANKL in GCF were measured by chemiluminescence and enzymelinked immunosorbent assay.

RESULTSThe E2 and OCN levels were significantly higher in the ovulation period group than in the menstrual period group (P < 0.05). No significant differences were found in RANKL and OPG levels between the two groups (P > 0.05). Finally, no significant difference was found in RANKL/OPG ratio between the two groups (P > 0.05).

CONCLUSIONExerted force on teeth during the menstrual period may promote rapid tooth movement.

BACKGROUND:Palatal rugae assist for consonantal formation;however,effect of palatal rugae on phonetics has been previously reported to be involved in different complete denture base plates of recipients.OBJECTIVE:To qualitatively analyze the effe-cts of different palate base plate morphology on phonetics of edentulous jaw patients using a computerized speech lab.DESIGN,TIME AND SETTING:A contrast study was performed at the Department of Stomatology,Beijing Hospital of Healthy Administration,and at the Department of Otorhinolaryngology,Beijing Friendship Hospital affiliated to Capital Medical University between February 2007 and February 2008.PARTICIPANTS:Ten edentulous jaw patients wore complete denture with smooth surface and palatal rugae complete denture base.METHODS:Spike,voice onset time and transition of 10 edentulous iaw patients were measured by computerized speech lab when/da/,/ta/,/sa/,and/na/were pronounced.MAIN OUTCOME MEASURES:Spike.voice onset time and transition.RESULTS:Spikes were observed in all syllables.When/da/and/ta,were pronounced.voice onset time in the smooth surface group was significantly shorter than palatal rugae group(P<0.05):voice onset time of/d/and/t/in the palatal rugae group was similar to normal value(P>0.05).When/da/and/ta/ were pronounced,transition frequency in the smooth surface group was significantly lower than palatal rugae group(P<0.05),while that in the palatal rugae group was similar to normal value(P>0.05).CONCLUSION:As an anatomical landmark,palatal rugae contribute to phonetic restoration and consonant articulation of edentulous jaw patients.Computerized speech lab can quantitatively analyze phonetic changes after complete denture restoration and may be used as guidance for clinical dental prosthetics.

BACKGROUND:Hyaluronic acid has antioxidant, immune regulation, anti-inflammatory roles as wel as promotes wound healing. Hyaluronic acid is more and more applied in the treatment of chronic periodontitis and achieves a significant effect. OBJECTIVE: To observe the clinical effects of local application of sodium hyaluronate in the treatment of chronic periodontitis. METHODS:Sixty cases of chronic periodontitis (300 teeth) were selected. According to self-control method, the teeth in district A, 150 premolars or molars, were as experimental group, and other 150 teeth in district B served as control group. In the experimental group, periodontal scaling, subgingival scaling, and local application of Gengigel gel (0.2% hyaluronic acid) in the gingival sulcus were employed; in the control group, the treatment was same to that in the experimental group except local application of Gengigel gel. During 8-week folow-up, dental plaque index, sulcus bleeding index, probing depth, and clinical attachment loss were changed dynamicaly. RESULTS AND CONCLUSION:After treatment, al the measurement indexes were improved remarkably in the two groups. However, there was no difference in the dental plaque index between the two groups at 1, 4, 8 weeks after treatment. The sulcus bleeding index was lower in the experimental group than the control group at 1, 4, 8 weeks after treatment (P < 0.05). The periodontal probing depth of the experimental group was lower than that of the control group at 4 and 8 weeks (P < 0.05). The clinical attachment loss was lower in the experimental group than the control group at 8 weeks (P < 0.05). These findings indicate that periodontal treatment with local application of sodium hyaluronate in the gingival sulcus is significantly effective for the treatment of chronic periodontitis.

OBJECTIVE: To explore the effects of Shenfu Injection on prostacyclin, thromboxane A2 and the activities of ATPases in rats exposed to hepatic ischemia-reperfusion injury. METHODS: Twenty-four male Wistar rats weighing 200-250 g were randomly divided into two groups: Shenfu Injection (SF)-treated group (rats were treated with Shenfu Injection of 10 ml/kg through intraperitoneal injection) and untreated group (rats were administered with normal saline at the same dose and served as a control group). Hepatic ischemia was caused by Pringle's maneuver and lasted for fifteen minutes, and then one-hour or three-hour reperfusion was performed. Venous blood samples for the measurement of thromboxane B(2) (TXB(2)) and 6-keto-prostaglandin F(1 alpha)(6-keto-PGF(1 alpha)) were collected three hours after reperfusion. Liver tissue samples were collected one hour or three hours after reperfusion for the measurement of Na(+)-K(+)-ATPase and Ca(+)-Mg(+)-ATPase and for morphological studies. RESULTS: Plasma TXB(2) was lower in the SF-treated group than that in the untreated group after three-hour reperfusion (P>0.05), while 6-keto-PGF(1 alpha) was higher in the SF-treated group than that in the untreated group (P>0.05). The ratio of TXB(2) and 6-keto-PGF(1 alpha) was significantly lower in the SF-treated group than that in the untreated group (P<0.05). The activities of Na(+)-K(+)-ATPase and Ca(+)-Mg(+)-ATPase in the SF-treated group were improved obviously. A three-hour reperfusion after fifteen-minute ischemia caused important hepatic histological alterations. Marked structural abnormalities were observed in the untreated group, such as massive hepatocyte swelling, necrosis, mitochondria edema and vacuolar changes. In the SF-treated group, hepatic tissue injury was reduced significantly. CONCLUSION: Shenfu Injection protects hepatic tissue from ischemia-reperfusion injury, and such protective effects are achieved by decreasing the ratio of thromboxane A(2) and prostacyclin, and increasing the activities of Na(+)-K(+)-ATPase and Ca(+)-Mg(+)- ATPase.

Objective To investigate the fatigue experience of the community-dwelling frail elderly to establish the conceptual model.Methods Grounded theory was adopted.With MAXQDA v10.4.15.1for 3 levels coding,the conceptual model of fatigue experience of community-dwelling frail elderly people was structured through constant comparison and in-depth analysis.Results Multi-response,selfmanagement,safe and belonging,hitting rock bottom,accepting and transferring formed the conceptual model.Conclusions Based on the conceptual model,nurses should pay more attention to concern about the fatigue experience of community-dwelling frail elderly people,and probe different assessment methods to enrich comprehensive geriatric assessment (CGA),then improve the community health service level and the quality of elderly people's life.

The kinetics of batch and fed-batch cultures of recombinant Escherichia coli to produce humanlike collagen were investigated. Through examining the density of substrate and the amount of mushrooms and the density of products during the process of fermenting, a set of kinetic models are set up. The influence of cell without plasmid was considered. The results show that the kinetic model may well simulate the fermenting process.