An extranodal lymphoma, primary central nervous system lymphoma(PCNSL) has rarely been reported. PCNSL is commonly classified as a primary diffuse large B-cell lymphoma with pathology. The WHO classification of haematopoitic and lymphoid tissues(4th Edition, 2008) has listed primary diffuse large B-cell lymphoma as a independent disease entity. Current clinical diagnosis of PCNSL is this article in reviewed.

Objective To investigate and analyze the problems of nursing undergraduate during clinical practice period,and to give improving measures and provide experiences for im-proving clinical teaching quality.Methods The study was carried out through anonymous inves-tigative questionnaire that included student group(n=98) and teacher group(n=22).Results The majority were satisfied with practice arrangement and teaching attitude.Forty four percent students thought that teaching methods should be improved.The major problems from the teacher's questionnaire were that students'basic knowledge needed to be strengthened and there were dif-ferent problems exsisting in studnets in different practice stage.Conclusions To give some im-proving suggestions with analyzing the questionnaires.

STAT3 can be activated by various cytokines and participate in the process of tumor cells proliferation,angiogenesis,invasion and chemotherapy resistance.Epithelial-mesenchymal transition (EMT)also plays an important role in the process of tumor invasion and metastasis and chemotherapy resistance.Studies have shown that STAT3 can regulate the process of EMT so as to change the invasion and metastasis abilities of tumor cells,and to enhance their ability of chemotherapy resistance.Discussion of the role and relation of STAT3 and EMT in tumor cells will be helpful to provide reliable theory for tumor molecular targeted therapy.

Objective　To explore the changes and significance of the circulating immunocomplexes(CIC) in patients with chronic iridocyclitis.Methods　We assessed circulating immunocomplexes in peripheral blood of 45 patients with recurrent uveitis and 42 healthy controls by PEG deposition with the biochemical analyzer to obtain levels of CIC different with recurrent uveitis.Results　Levels of CIC were significantly higher in active patients(27.358±6.729)than those in controls(13.459±6.164,P＜0.001) and inactive patients (16.248±6.233,P＜0.001),but patients (inactive) had significantly higher levels than those in controls (P＜0.05).Conclusion　Levels of CIC were found in the groups of active patients with recurrent uveitis (27.358±6.729), but levels of CIC in inactive patients fell. The result of this study suggest that recurrence of uveitis is related to immunocomplexes,and changes in the levels of CIC could be also a measure standard of therapeutic effects.

Objective To investigate the clinical manifestations of chronic pancreatitis(CP)and choice of the surgical therapy. Methods The clinicopathological and follpw-up data in 91 cases surgically treated in our hospital from January 1980 to January 2006 were retrospectively analyzed.Resuits The causes for CP were biliogenic one in 34 patients(37.4%),alcohol in 14(15.3%),iniury in 8(8.8%),acute pancreatitis in 14(15.3%)and idiopathic one in 20(22%).RelaPsing upper abdominal pain was the major symptom of CP.There were only two patients that were up with endoscopic sphincterotomy(EST)and the others were operated on.The operative morbiditv was 6.6%(n=6),and mortality 1.1%(n=1).Mean hospital stay was 17.7d.For the 9l patients with preoperative pain,the pain was relieved in 88.Conclusion The best operative procedure should be chosen for treatment of CP according to causes,clinical findings,imaging records and pathological examination.

Syncope is a common pediatric emergency event,which can be caused by various metabolic disorders different from other illness. The major metabolic anomalies include hypoglycemia, hyperventilation,electrolytes imbalance,hypoxemia and others, in which hypoglycemia is caused by hyperinsulinemia,pituitary and adrenal disease, diabetes, ketotic hypoglycemia, inherited metabolic disorders of sugar, organic acids and amino-acids,etc. This article introduced the common metabolic anomalies and their causes,diagnosis and therapy.

Objective To observe the clinical effect of alprostadil combined with Yiqi Huoxue Huatan Tongluo Decoction in treating arteriosclerosis obliterans.Methods 60 cases of lower extremity arteriosclerosis occlusion disease outpatient and hospitalized patients were randomly divided into treatment group and control group according to the random number table method, each group were 30, the oral administration of enteric coated aspirin experimental group is set to control group intravenous injection of alprostadil treatment for 4 weeks, the treatment group was treated with Huatan Tongluo Decoction on the basis of the control group.The clinical symptoms, blood vessel function (ABI),low density lipoprotein-cholesterol (LDL-C), total cholesterol( TC) were observed in the two groups of patients, and blood rheology indexes included whole blood viscosity, fibrinogen, liver and kidney function and adverse reactions.ResuIts Total effective rate of the treatment group was 93.33% than control group 73.33% (P<0.05), the treatment group of ankle brachial index ( ABI) was better than the control group, the treatment group TC, LDL-C, high shear whole blood viscosity, low shear whole blood viscosity, fibrinogen protein improve were better than those of the control group (P<0.05).ConcIusion Disease curative effect is better than pure alprostadil in the treatment of occlusion Huoxue Huatan Tongluo Decoction combined with alprostadil in the treatment of lower limb arteriosclerosis.

Intravascular large B cell lymphoma is a rare subtype of diffuse large B cell lymphoma. Abnormal proliferation of intravascular lymphoma cells is its pathological feature with aggressive clinical behavior such as easy invasive feature, rapid disease progression, poor prognosis and low survival rate. We review the progress in recent research on classification, diagnosis, treatment and prognosis of intravascular large B cell lymphoma.

Primary central nervous system lymphoma (PCNSL) is a rare type of malignant lymphoma which originates in the central nervous system without spreading to other systems. It is more predisposable to immunodeficient individuals. However, an increase in the incidence of PCNSL has been also observed in the healthy population in recent years. PCNSL has short phase of clincal release, and easy to relapse with poor prognosis. Some studies have shown that relative prognostic factors were associated with age, performance status, the radiotherapy and chemotherapy modalities, the response to early adminstration of the glucocorticoid,tissue pathologic type and the molecular biologic marks.

Recent studies show that tumor cells get rid of the connections between cells,and induce tumor invasion and metastasis through epithelial-mesenchymal transition (EMT).EMT becomes an important way to invasion,metastasis and chemotherapy resistance of epithelial cell carcinoma which accounting for more than 90％ of malignant carcinomas.Members of Snail family,especially Snail is regarded as important adjustment factor of EMT,which induce the transformation from epithelial cell to mesenchymal phenotype through competitive inhibition E-calcium protein gene expression.Many researches show that EMT exists widely in digestive system tumors,which is closly related to the invasion,metastasis and chemotherapy resistance of digestive system tumors.