The problem of intellectual property of traditional Chinese medicine were discussed, the TCM protection system and patent protection system are studied. The author puts forward some deficiencies of the existing protection system, and puts forward some improvement methods possible.

Health Promotion ; organization & administration ; Humans ; Occupational Health ; Occupational Health Services ; organization & administration ; Risk Assessment

Regeneration ; Tissue Engineering ; Vocal Cords

Asian Continental Ancestry Group ; China ; Humans ; Laboratories ; organization & administration ; Measles ; prevention & control ; Measles Vaccine ; administration & dosage

Child ; Humans ; Vocal Cord Paralysis ; diagnosis ; therapy ; Vocal Cords

Thirty-four patients with chronic lingual tonsillar hypertrophy were treated in our department from 1994 to 2000. There were 18 males and 16 females ranging in age from 21 to 60 years old. The clinical feature of lingual tonsillar hypertrophy usually appeared a series of pharyngeal symptoms, such as foreign-body sensation, sore throat, speech change, difficulty in swallowing, dysapnea and obstructive sleep apnea. The CO2 laser surgical lingual tonsillectomy was used for these patients. Result showed that the cure rate was 100% without any serious complications by following up 2 months to 3 years. The variety of presentations of lingual tonsillar hypertrophy and methods of surgical treament were discussed.

OBJECTIVE:To provide reference for reasonably designing package inserts of ointment for manufacturers. METH-ODS:According to items included in Management Regulation for Package Insert and Label and Specification for Chemicals and Bi-ological Products for Treatment,labeled items in package inserts of 51 kinds of ointment for external use during Jan.-Jun. 2016 in our hospital were analyzed. RESULTS:Among the 51 kinds of ointment,39 were domestic varieties and 12 were imported variet-ies. In the package inserts of 39 domestic varieties,items with lower labeling rates were overdose,pharmacokinetics,use guid-ance,pharmacology and toxicology,with labeling rates of 2.6%,5.1%,15.4%,28.2%;while the labeling rates of imported vari-eties were 16.7%,83.3%,75.0%,100%. Compared with package inserts of imported ointment,composition,dosage and usage, adverse reactions,contraindications,precautions,drug interactions,medication for special populations were not enough detailed in domestic ointments. CONCLUSIONS:It is suggested that manufacturers consult medicine experts, list all auxiliary materials through Management Regulation for Drug Description and Label,refine and improve the labeling contents of dosage and usage,ad-verse reactions,precautions,medication for special populations,pharmacology and toxicology,overdose,etc. In addition,admin-istrative departments should strengthen the regulatory approval efforts.

Objective To observe the effect of depside salt from Salvia Miltiorrhiza on platelet endothelial nitric oxide synthase(eNOS) activity in health adults.Methods Peripheral venous blood was collected,platelets were isolated with gel-filtration chromatography and incubated with eNOS agonist histamine,eNOS inhibitor L-NAME and different concentrations of depside salt from Salvia Miltiorrhiza(0.1,1,10,100,1000 mg/L) for 30 minutes,then eNOS activity was measured as formation of 3H-L-citrulline from 3H-L-arginine.Results(1)Platelet eNOS activity was significantly inhibited after incubated platelets with L-NAME and increased after incubated with histamine(P

Asialoglycoprotein receptor(ASGPR),also called galactose receptor,is predominantly expressed on the sinusoidal surface of mammalian hepatocytes and is involved in many physiological functions.For many years ASGPR has been applied for targeting hepatocytes in drug and gene delivery and for functional mapping of the liver,and considerable progress has been made.ASGPR-mediated liver-targeted drug delivery mainly involved anti-tumor drugs and cholesterol-lowering drugs,etc.Liver-targeted gene delivery was often seen in antisense drugs.The research of hepatic imaging mainly involved the evaluation of liver function and identification between hepatocellular carcinoma and hepatic metastasis of tumors.In addition,researchers have also extended its applications to some new fields,such as three-dimension culture of hepatocytes,hepatocytes screening,and hepatocytes transplantation.New achievements in studies of ASGPR-mediated liver targeting are reviewed in this article.

With chinese pharmaceutical companies in the rapid development, there are many factors restricting their development, this article through consulting relevant literature, data and investing, analyzing the shortage of the pharmaceutical enterprises at the present stage in China and the factors of restricting their development, so as to put forward the solution to the current situation of pharmaceutical enterprises in China and the related measures, make more long-term and healthy development of pharmaceutical enterprises in China.