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Our experiments have shown that bee venom possesses effects of significantly increasing the fluidity of erythrocyte membrane,markedly decreasing the whole blood and plasma viscosities,accelerating erythrocyte microelectrophoresis speed and reducing erythrocyte rigidity index in rabbit. The results showed that bee venom can markedly change some of the parameters of hemorrheology,and possess certain effects in promoting blood circulation to remove blood stasis.

Objective To explore the conventional MRI,diffusion-weighted imaging (DWI)characteristics and the pathological basis of angiomatous meningioma.Methods The conventional MRI,DWI and pathological manifestations of 7 cases with angioma-tous meningioma confirmed by surgery and pathology were analyzed retrospectively.The apparent diffusion coefficient (ADC)value of the tumors and contralateral normal brain parenchyma were measured and compared with each other.Results Among the 7 ca-ses,5 cases were in the convexity of brain (4 cases in the frontal part and 1 case in the parietal part),and 2 cases in the parasella. 6 cases showed hypointense on T1 WI and hyperintense on T2 WI,and 1 case showed isointense on both T1 WI and T2 WI.The necro-sis within the tumor was seen in 2 cases.The flowing void phenomenon was seen in 6 cases.The significant peritumoral edema was seen in 5 cases on FLAIR.Significant enhancement on contrast-enhanced T1 WI was seen in all the cases.The average ADC value of the tumors (1.35×10 -3 mm2/s)was significently higher than that of the contralateral normal parenchyma (0.92 × 10 -3 mm2/s) (t=7.21,P <0.01).Mature vessel component was seen on pathological section in all the cases.For immunohistochemically analy-sis,the expression of vimentin (Vim)was positive in 6 cases and scattered positive in 1 case.The expression of epithelial membrane antigen (EMA)was positive in all the cases.Conclusion The MRI features of angiomatous meningioma are closely correlated with rich blood vessels.The ADC value of the tumor is higher than that of the contralateral parenchyma,which is helpful for the diagno-sis.

Multiple risk factors lead to occurrence of cardiovascular diseases in common.Besides confirmed tradition-al risk factors,such as diabetes mellitus,dyslipidemia,smoking and hypertension etc.,some new risk factors have been found in recent years.The confirmed risk factors need further research,while the new risk factors need en-hanced study.

Doctor-patient relationship is a special relationship between people in special circumstances during a special peri -od, which is directly related to the harmony and stability of society as well as people's quality of life.Values are the fundamental views of people, including the understanding of the nature , composition and standards of values .Doctors and patients are consistent in goals , interests and ideals , having the same objectives to overcome diseases , promote health , and prolong lives .They are essentially unified in values.However, there are some inharmonious phenomena in the relationship between doctors and patients .Efforts should be made to improve the present doctor-patient relationship by the whole society besides doctors and patients , aiming to establish a harmonious doctor-patient relationship of mutual respect , mutual trust , mutual tolerance and mutual cooperation on the basis of common values .

To explore the allocation and equity of health resource in Changsha between 2007 and 2013 and to provide references for government to carry out regional health planning. Method:General statistical analysis was used to describe changes of health resource allocation in Changsha;from the perspective of the population and geography of the nine counties in Changsha, the equality and change of the configuration among doctors, nurses and hospital beds were analyzed by using the Gini coefficient and Theil index. Results:1) The per capita amount of health resources in Changsha increased gradually, and health resources were mainly concentrated in urban areas. 2 ) The Gini coeffi-cients of doctors, nurses and hospital beds was 0. 24~0. 46 according to population distribution between 2007 and 2013 in Changsha, and the Gini coefficient of all health resources by geography was 0. 59~ 0. 79 and peaked in 2009 to then decrease year after year. Following a comparison of the two kinds of regions, the Gini coefficient of urban are-as was significantly higher than that of rural areas, and the Gini coefficient of nurses was the highest among all health resources. 3) Changes in the Theil index were consistent with the Gini coefficient. The difference in the degree of re-source allocation in urban areas exhibited a rising trend, The Theil index was higher than each regional difference. Conclusion:Overall, the equity of allocation of health resources in Changsha between 2007 and 2013 gradually im-proved year by year. The equity of population configuration was greater than that of geographical configuration, and the equity of rural areas was superior to that of urban areas;the equity of the configuration of nurses was poor. The difference between areas is the main factor affecting the equity of Changsha’s health resource allocation.

Objective:To explore the relationship between coronary slow flow (CSF) and vascular inflammatory fac-tors .Methods :A total of 229 inpatients with normal coronary angiography (CAG) results were selected as research object .According to CAG TIMI flow and corrected TIMI frame count ,patients were divided into CSF group (n=102 ,no obvious lesion in epicardial coronary artery but coronary flow was slow ) and normal coronary group (n=127 ,completely normal epicardial coronary artery and blood flow ) .General clinical data were collected ,vascular inflammatory factors were measured and their relationship with CSF was analyzed .Results:Compared with normal coronary group ,there were significant rise in levels of high sensitive C reactive protein [ (1.41+0.72 ) mg/L vs . (2.82+0.58) mg/L] ,interleukin 1 [ (0.18 ± 0.05)μg/L vs .(0.26 ± 0.06)μg/L] and interleukin 6 [ (0.363 ± 0.016) ng/L vs .(0.465 ± 0.015) ng/L] in CSF group , P<0.05 all .Logistic regression analysis indicated that vas-cular inflammatory factors were risk factor for CSF occurrence (OR= 1.008 , P= 0.015 ) .Conclusion:Coronary flow velocity is closely related to vascular inflammatory factors .

The basic functions of the Na+/K+ -ATPase is to maintain the balance of the Na+/K+ electrochemical gradient. The latter is indispensable for maintaining cell osmotic pressure,regulating cell volume,and maintaining excitable membrane resting potential. The maintenance of the Na+/K+ -ATPase activity plays the important roles in neurotransmitter uptake in neurons and Ca2+ effiux. The decreased Na+/K+ -ATPase activity and dysfunction participate in the process of ischemic brain injury after cerebral ischemia. Ischemic precondi-tioning induces ischemic tolerance by maintaining the Na+/K+ -ATPase activity after ischemia.Cardiotonic steroids and citicoline may play a neuroprotective effect on cerebral ischemia by improving the Na +/K+ -ATPase activity.

Objective To explore the expression of cell apoptosis regulatory elements in esophageal canceration course. Methods 60 specimens of esophageal carcinoma and corresponding adjacent no cancerous tissue were detected quantitatively by propidium iodide(PI) stain and indirect immunofluorescence of fluorescein isothiocyanate(FITC) using flow cytometry(FCM) equipment. Results Expression of bcl-2 and c-FLIP in esophageal carcinoma was significantly higher, and Fadd, Caspase-8 and Caspase-3 were significantly lower than that in adjacent tissues (P <0.01). There was positive correlation between Fadd and Caspase-8 gene (P <0.01 or P <0.05). The expression of Fadd was positively correlated to Caspase-8. Comparing with normal epithelium and dysplasia tissue, DNA content and heteroploid cells were increased significantly in esophageal carcinoma. Conclusion During the esophageal canceration course, expressions of relevant cell apoptosis regulatory elements were abnormal. DNA content and heteroploid cells were increased significantly in esophageal carcinoma.

BACKGROUND:Animal models can be used to study specific scientific problems of intervertebral disc biology.Model of disc degeneration is mainly used to resolve the relevant disease mechanisms and scientific and security issues of the treatment.OBJECTIVE:To summarize currently used experimental animal models of intervertebral disc degeneration study,and to dynamically observe and confirm the pathological process of disc degeneration based on disc imaging,morphology,biomechanics and bi(o)chemicel changes.METHODS:Using "intervertebral disc degeneration,animal models,in vivo,in vitro" in English as the search words,Cochrane Library (No.1 2009),Cochrane Library Database of Controlled Clinical Trials (No.1 2009),MEDLINE from 1990 to March 2009,EMbase from 1990 to March 2009,Current Controlled Trials,and the National Research Register were retrieved.Literature was limited to English language.The disc imaging,morphology,biomechanical end biochemical composition and other indicators,as well as the pathological process of disc degeneration served as the evaluation indices.The articles related to the intervertebral disc cell culture models,the whole disc tissue culture model,mechanical model,injury model,biological model,genetically modified models,spontaneous models were included.The repetitive researches and those unrelated to animal models of intervertebral disc degeneration were excluded.RESULTS AND CONCLUSION:The establishment of a reliable animal model can provide favorable conditions for studying the pathogenesis of intervertebral disc degeneration,at the same time,provides a good experimental vehicle for various researches about the repair treatment of intervertebral disc degeneration.Animal models of intervertebral disc degeneration can be divided into two categories:in vitro models and in vivo models of disc degeneration and repair.The former can be assigned into disc cell culture models and whole disc tissue culture model;the latter is assigned into mechanical models,injury models,biological models,genetically modified models,spontaneous models and so on.The above models are commonly used in the study of the occurring mechanism of disc degeneration,as well as the feasibility and effectiveness of a variety of treatments.However,there is still no generally accepted animal models as an ideal disc degeneration model,various types of models reported have their own advantages and disadvantages.