1.Research on optimization of lower limb parameters of cardiopulmonary resuscitation simulation model based on genetic algorithm.
Journal of Biomedical Engineering 2014;31(5):1139-1143
Sudden cardiac arrest is one of the critical clinical syndromes in emergency situations. A cardiopulmonary resuscitation (CPR) is a necessary curing means for those patients with sudden cardiac arrest. In order to simulate effectively the hemodynamic effects of human under AEI-CPR, which is active compression-decompression CPR coupled with enhanced external counter-pulsation and inspiratory impedance threshold valve, and research physiological parameters of each part of lower limbs in more detail, a CPR simulation model established by Babbs was refined. The part of lower limbs was divided into iliac, thigh and calf, which had 15 physiological parameters. Then, these 15 physiological parameters based on genetic algorithm were optimized, and ideal simulation results were obtained finally.
Algorithms
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Cardiopulmonary Resuscitation
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Death, Sudden, Cardiac
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Electric Impedance
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Hemodynamics
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Humans
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Leg
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Models, Cardiovascular
2.Research on neuroprotective effects of mesenchymaI stem ceIIs in retinaI disease
International Eye Science 2015;(3):464-466
· Mesenchymal stem cells ( MSCs ) are a population of multipotent stem cells with various neurotrophins from bone marrow which are widely used in tissue, cell repair and alternative research.Recently, some researches have shown that MSCs could enhance the viability of neurons under a pathological circumstance by secreting some neurotrophins. So the neuroprotection of MSCs can provide a new method of the treatment on retinopathy that it possible to promote cells survial and functional recovery.Here we make a brief review on the secretory function of neurotrophin and neuroprotective effects of MSCs on retinal cells and its application in the treatment of retinal disease.
3.Application of procalcitonin in clinical surgery
International Journal of Surgery 2012;39(1):39-42
Procalcitonin is a biomarker to diagnose the extent and severity of systemic bacterial infection.Procalcitonin is applied in diagnosis and treatment of systemic inflammatory response syndrome and severe acute pancreatitis.The article reviews application of procalcitonin in clinical surgery and guides use of anti-bacterial agents.
4.Transjugular intrahepatic portosystemic shunt and hepatic encephalopathy
Parenteral & Enteral Nutrition 2009;16(4):243-246
Transjugular intrahepatic portosystemic shunt (TIPS) has been developed for two decades in order to treat portal hypertension accompanying with upper gastrointestinal hemorrhage and refractory ascites.TIPS may cause the development of hepatic encephalopathy (HE).TIPS induces portalsystemic shunt and leads to hemodynamics chaos. Hepatic encephalopathy belongs to the complications of the portal hypertension. There are many possible predictors of the post-TIPS HE. The relationship between TIPS and HE was reviewed.
5.Survey in anxiety status of new nurses in emergency department
Chinese Journal of Practical Nursing 2009;25(8):59-60
Objective To describe the anxiety status of new nurses in emergency department so as to put forward strategies for nursing management. Methods Thirty-two new nurses (working time less than 2 years) from emergency department of two class Ⅲ- A general hospitals in Xiamen were surveyed by using Zung self-rating anxiety scale (SAS). Results The average of SAS total score showed significant difference from that of the Chinese norm, but no significant difference could be seen in the score of SAS be-tween college and baccalaureate nurses.Nurses with different working length showed significant difference in SAS score. Conclusions Anxiety status of new nurses in emergency department is serious, nursing man-agers should make more efforts to conduct mental health education and improve psychological quality of new nurses in emergency department to relieve their anxiety.
6.Primary hepatocellular carcinoma patients with multiple nodules increased short-term recurrence after radical resection
Chinese Journal of Hepatobiliary Surgery 2015;21(12):816-820
Objective To investigate the relationship between primary hepatocellular carcinoma (HCC) with multiple nodules and short-term recurrence after radical resection.Methods We retrospectively analyzed the clinical data and follow-up of 692 consecutive HCC patients who underwent curative resection at the Affiliated Hospital of Qingdao University from January 2000 to December 2011.The diagnosis of multiple nodules was based on preoperative imaging data and observations in operation.Results Of 692 HCC patients, 126 patients had multiple nodules (18.2%, the MN group) and 566 patients had a single nodule (71.8%, the SN group).The 1-, 2-, 5-, and 10-year overall survival (OS) rates were 86.5%,72.2%, 38.1%, and 23.2% for the MN group, and 93.8%, 82.7%, 58.2%, and 35.7% for the SN group, respectively (P < 0.05).The 1-, 2-, 5-, and 10-year disease-free survival (DFS) rates were 68.6%, 46.8%, 27.2%, and 19.8% for the MN group, and 80.2%, 62.1%, 42.0%, and 34.6% for the SN group, respectively (P < 0.05).Cox regression model analysis showed a maximum nodule diameter of > 5 cm was an independent risk factor of short-term recurrence in the MN group.Conclusions The prognosis of HCC patients with multiple nodules after radical resection was poorer and the short-term recurrence rate was significantly higher than those patients with a single-nodule.A maximum nodal diameter of > 5 cm was an independent risk factor of short-term recurrence for patients with multiple nodules after radical resection.Therefore, patients with multiple nodules, especially > 5 cm, should be followed up closely and they are good candidates for a multiple disciplinary team (MDT) treatment.
7.Relationship between abnormal activation of HGF/c-Met signaling pathway and EGFR-TKI acquired resistance in non-small cell lung cancer
Journal of International Oncology 2016;43(9):703-705
Targeted therapy such as the epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI)has made huge progress in treatment of non-small cell lung cancer (NSCLC).However,the emergence of acquired drug resistance is an inevitable result of the targeted therapy.The hepatocyte growth fac-tor/c-mesenchymal-epithelial transition factor (HGF /c-Met)signaling pathway participates in cell formation, migration,angiogenesis and other important cellular processes of multiple tumors.The abnormal activation of this signaling pathway plays the pivotal role in the acquired resistance to EGFR-TKI.Recently,some clinic tri-als prove that HGF /c-Met inhibitors can make clinical benefit of some NSCLC patients with acquired drug re-sistance of EGFR-TKI.
8.Research progress of pharmacological effects of musk ketone on the brain disease
Chinese Journal of Primary Medicine and Pharmacy 2017;24(11):1742-1744
Musk ketone(3-methyl cyclopentadecanolide) is the main active ingredient of the artificial musk,it has multiple pharmacological effects,including anti-dementia,cerebral ischemia,anti-inflammatory effects and so on.This article outlines the main pharmacological effects of musk ketone on brain diseases in the recent years, aim to further research, investigation and utilization deeply of it.
9.The implementation and reflection of the application of cross-disciplinary joint teaching model on medical humanity courses
Chinese Journal of Medical Education Research 2016;15(10):1017-1021
Objective To explore the difference between the results of the cross-disciplinary joint teaching method and the traditional teaching method in medical humanity courses.Method 128 students in one military medical university were selected to be randomly assigned to the study group and the control group,using the cross-disciplinary joint teaching mode (study group,n=64) and traditional teaching mode (control group,n=64) in medical humanity courses.For the joint teaching mode,we compiled the teaching materials of medical humanities,formed the teaching team and organized the academic communication after class by social media.After all courses were finished,the subject cognition and approval of whole students were evaluated by the unified arranged examination and questionnaire.Then the data was processed by SPSS 18.0.Results On the aspect of subject cognition,the total scores of the study group were higher than control group in health law [(76.2 ± 3.34) vs.(72.5 ± 4.76);t=3.32,P=0.000] and medical ethics [(75.3 ±2.93) vs.(68.3 ± 3.10);t=4.01,P=0.000].On the aspect of subject approval,the recognition of the students of the study group in these three subjects were more than those of the control group except the selfevaluation of medical psychology (P=0.000).Conclusion The application of cross-disciplinary joint teaching method on medical humanity courses contributes evidently to the promotion of the medical humanity quality of clinical medical students.To implement this model,however,multi-sided resources are needed for colleges to coor-dinate,for perfect results require more practical exploration.
10.Effect of amiodarone hydrochloride treatment time on treatment success rate of ventricular premature beats after radiofrequency ablation
Chinese Journal of Biochemical Pharmaceutics 2017;37(1):229-232
Objective To investigate the effect of treatment time with amiodarone hydrochloride on treatment success rate of ventricular premature beats after radiofrequency ablation. Methods 46 cases of patients with frequent premature ventricular arrhythmia who received RFCA for the first time in department of gardiology,huangyan hospital of wenzhou medical university from February 2013 to February 2015 were selected,and randomly divided into two groups,the control group were treated with amiodarone hydrochloride for one months,the study group were treated with amiodarone hydrochloride for six months.Left ventricular function and structural parameters,heart rate variability were measured in two groups,the main clinical symptom scores,success rate,efficacy and safety were compared. Results Compared with before treatment,two groups of LVESD,LVEDD and PVC decreased (P<0.05),LVEF increased (P<0.05),SDNN,rMSSD,PNN50,LF and HF increased (P<0.05),scores of palpitation,shortness of breath,chest tightness and main symptom score decreased (P<0.05).Compared with the control group,level of PVC in the study group was lower (P<0.05),LVEF was higher(P<0.05),LVESD and LVEDD were had no significant differences,levels of SDNN,rMSSD,PNN50,LF,HF were higher (P<0.05),scores of palpitations,shortness of breath,chest tightness main symptom score were lower (P<0.05).There were no significant differences in the success rate, clinical efficacy and adverse reaction rate between the two groups. Conclusion The time of taking amiodarone after radiofrequency catheter ablation in patients with PVCs,but taking six months and medication compared to one month,can reduce heart palpitations,chest tightness and other symptoms,and improve left ventricular function,with high security.