Objective To observe the clinical efficacy of deep needling with long needles plus electroacupuncture in treating lower-limb pain due to lumbar intervertebral disc herniation (LIDH).Method Totally 139 patients with lower-limb pain due to LIDH were randomized into a treatment group of 76 cases and a control group of 63 cases. The treatment group was intervened by stimulating spinal nerve by deep needling with long needles (75 mm) plus electroacupuncture, while the control group was by conventional needling plus electroacupuncture. The Visual Analogue Scale (VAS) was observed before and after intervention, and the clinical efficacies were compared between the two groups.Result The total effective rate was 80.3% in the treatment group versus 57.1% in the control group, and the difference was statistically significant (P<0.05). The VAS scores were significantly changed after intervention in both groups (P<0.05). After intervention, there was a significant difference in comparing the VAS score between the two groups (P<0.05).Conclusion Deep needling with long needles plus electroacupuncture is an effective method in treating lower-limb pain due to LIDH.

Objective To explore the characteristics of blood vitamins A, B2, B6, B12, D, E, K1, K2 and folic acid and their correlation with severity in patients with metabolic-related fatty liver disease (MAFLD). Methods　From September to December 2022, a total of 473 cases of residents were recruited through community MAFLD screening activities and their health information was obtained through questionnaire survey and physical examination. The severity of hepatic steatosis was determined with FibroScan, and vitamin concentrations were determined with liquid chromatography-tandem mass spectrometry. Two independent samples' t-tests were used to assess the differences between the two groups, and univariate chi-square tests and multivariate logistic regression analysis were used to explore the related factors of MAFLD. Results　Of the 473 inhabitants, 195 (41.23%, 195/473) met the diagnostic criteria for MAFLD, including mild 43 (22.05%, 43/195) cases of fatty liver, 88 (45.13%, 88/195) cases of moderate fatty liver, and 64 (32.82%, 64/195) cases of severe fatty liver. Using healthy residents collected during the same period as controls, the overall mean of vitamins A, E, K1, and K2 in the MAFLD group was higher than that of the healthy group, with a statistical difference (P<0.05). Furthermore, the concentrations of vitamins A, E, K1 and K2 increased with the severity of fatty liver [R=0.149, P=0.004; R=0.245, P<0.001; R=0.110, P=0.032; R=0.129，P=0.012]. There were statistically significant differences (P<0.05) in the blood levels of vitamin A and E between patients with moderate or severe fatty liver and the healthy population. The blood vitamins K1 and K2 in severe fatty liver patients were also different from those of healthy people (P<0.05). However, there was no significance between folic acid, vitamin D, B2, B6, B12, and MAFLD (P>0.05). Through univariate chi-square analysis and multivariate logistic regression analysis, it was found that male [Wald=5.789, P=0.034，OR=1.598(1.037-2.463)] and vitamin E≥8.13 μg/mL[Wald=14.632，P<0.001，OR=2.378(1.522-3.674)] were risk factors for moderate and severe MAFLD. Conclusions The concentrations of vitamin A, E, and K in the blood are increased in patients with MAFLD compared to the healthy population, and they are positively correlated with the severity of MAFLD. ale gender and high levels of vitamin E may be related to moderate to severe MAFLD.

Objective: To understand the epidemiological characteristics of school foodborne disease outbreaks in Liaoning Province, and to provide scientific basis for effective prevention and control of school foodborne disease outbreaks in the future. Methods: An epidemiological study was conducted on the school foodborne disease outbreaks reported by the National Foodborne Disease Outbreak Surveillance System in Liaoning Province from 2011 to 2021. The influencing factors of school foodborne disease outbreaks were analyzed by binary Logistic regression. Results: From 2011 to 2021, a total of 29 school foodborne outbreaks were reported in Liaoning Province, with accumulative cases of 1 003, 218 hospitalized cases and no death cases. The number of outbreaks and cases were the highest in 2020(7 cases, 320).The incidence of the disease showed a bimodal distribution throughout the year, with the peak in March and December, and the number of outbreaks in schools in March was the largest(8 cases,27.59%). Primary and secondary schools reported the largest number of incidents, cases and hospitalizations(12 cases, 555, 97). The mean interval of outbreak reporting was longest in junior college (32.01 h), while the mean duration of outbreak was longest in university ( 52.33 h ). Most of cases (536,53.44%) had vomiting symptoms. Staphylococcus aureus toxin, Bacillus cereus toxin and Norovirus caused more incidents(3 cases for each one). In addition to the unknown causes, improper processing and cross contamination were the main causes(6 cases for each one). Headache index was positively correlated with outbreak size in schools ( OR = 9.78). Clinical symptoms fever and exposure duration event indexes were positively correlated with the reporting time interval of school outbreak events ( OR =7.08, 22.40)( P <0.05). Conclusion It is necessary to strengthen the management and supervision of school catering institutions in winter and spring, optimize the reporting process, and effectively reduce the scale of outbreaks of foodborne diseases in schools.

AIM: To compare the efficacy of intravitreal injection of ranibizumab(IVR)and intravitreal injection of conbercept(IVC)in children with retinopathy of prematurity(ROP).METHODS: Retrospective study. A total of 1 100 eyes with ROP treated with intravitreal anti-VEGF at our hospital from January 2015 to June 2023 were included. According to the different therapeutic drugs, the children were divided into two groups: IVR group and IVC group. According to the degree of ROP, the patients were divided into three groups: aggressive ROP(A-ROP), Zone Ⅰ type 1 ROP and Zone Ⅱ type 1 ROP. The reactivation and retreatment between the two groups were compared after propensity score matching(PSM)analysis, and they were followed-up for at least 3 mo after surgery.RESULTS: In Zone Ⅱ type 1 ROP, there was a statistically significant difference in the rates of reactivation and retreatment between the IVR and IVC groups(P<0.05); however, in A-ROP and Zone I type 1 ROP, there were no statistically significant differences in the rates of reactivation and retreatment between the two groups(P>0.05). The risk of reactivation and retreatment of Zone I type 1 ROP was higher than the Zone II type 1 ROP. Furthermore, the use of drugs and corrected gestational age of first treatment were influencing factors of lesion recurrence and retreatment.CONCLUSION: There is a significant difference in the initial cure effect between the two drugs in Zone II type 1 ROP, with the reactivation and retreatment rates of the IVC group being much lower than those of the IVR group.