Objective To explore the antagonistic effect of Schistosoma japonicum soluble adult worm antigen (SWA)and solu-ble egg antigen (SEA)in the mice with type 1 diabetes.Methods The 24 successful modeling type 1 diabetes mice were randomly divided into three groups (A,B,C group,n=8).SWA and SEA of Schistosoma japonicum were prepared.Mice in A group were immunized by abdominal subcutaneous multi-point injection SWA.Mice in B group were immunized by abdominal subcutaneous multi-point injection SEA.And mice models of C group were immunized by PBS instead of antigen through abdominal subcutaneous injection.The mice got immunization once a week,a total of four times.4 weeks later,the mice were sacrificed,and serum speci-mens were collected for the determination of serum levels of IL-4 and IFN-γby double-antibody sandwich ELISA,while pancreas tissues were collected and the pathological changes were observed.Results The serum IL-4 level of B group [(23.87 ±4.85)pg/mL]was higher than C group [(4.39 ± 0.56 )pg/mL],with significant differences (P < 0.01 ),while the serum IFN-γ level [(271.85±26.04)pg/mL]was lower than C group [(362.79 ±32.50)pg/mL],also with significant differences (P <0.01).The serum IL-4 and IFN-γof A group were (5.09±0.37)pg/mL and (379.56±34.47)pg/mL,which had no difference with C group (P >0.05).The islet structure of mice in B group was not intact,however,the lymphocytic infiltration in B group was less than C group,and there was no lymphocytic infiltration in pancreatic islets in B group.Compared with C group,the pancreas of mice in A group did not have significant changes,lymphocytes infiltration was still visible in islets.The number of residual islet cells de-creased,and visible minority islet structure was destroyed.Conclusion SEA of Schistosoma japonicum has certain antagonism effect on type 1 diabetes in experimental mice.Its mechanism may be the reduction of Th1 response and the enhancement of Th2 response through increasing IL-4 level and decreasing IFN-γlevel.

Objective:To study the cognitive features of text anxiety. Methods: The cognitive features of text anxiety were explored by exploratory factor analysis and confirmatory factor analysis on the basis of interview,questionnaire surveying and criterion.Results:There were 6 cognitive factors leading to test anxiety: self-test, worrying, magnifying conclusion, resistance, preparing, self-efficacy.Conclusion: The 6 factors of cognition about text are related to text anxiety

Objective: To explore the differences between the internal social adaptation and external social behaviors of freshmen. Methods: Make a survey of 198 freshmen on the internal adaptation and external by General Well-Being Schedule and Undergraduate Social Adaptation Questionnaires. Results:Freshmen' social adaptation mainly involves three factors: interpersonal communication, the state of campus life and performance of studies. The Cronbach alpha of 3 factors were 0.82, 0.87 and 0.90,and the re-test reliability was r=0.73 (P

Basic research in interventional radiology,including transcatheter artery perfusion especially,is progressing slowly due to lack of proper method.Microdialysis technique,a kind of accurate sampling technique in vivo,may help to solve the problem.Just as its name implies,microdialysis means tiny dialysis with advantages of authenticity,exactness and less error.Furthermore it has been applied widely and should be received with great attention and popularity.

The interventional therapy of chemoembolization is the first management of choice in treating unresectable hepatic carcinomas but with some side effects including liver function damage and bone marrow restraints which may affect the patients'life expectancy and living quality in the long run.The advancement of the combination of interventional treatment with Chinese drugs in managing liver carcinomas is a special presentation by the auther for further recommondation.

The articles concerning intensive effect and progress of interventional therapy for hepatocellular carcinoma (HCC) recurrence were comprehensively reviewed. Along with unceasing abundance of all interventional methods (including transcatheter arterial chemoemblization (TACE),percutaneous dehydrated ethanol injection,radio frequency ablation,percutaneous microwave therapy,argon-helium cryoablation,high-intensity focused ultrasound and radionuclide interventional therapy,etc),combined interven-tional therapies mainly TACE were increasingly appreciated in postoperative HCC recurrence,but still have to be further standardized. With further emerging and maturing of new technologies,such as antiangiogenesis,gene therapy and targeted therapy on HCC metastatic and recurrence specific cycle; the effect of combined therapy will be further promoted. Interventional therapy will play an important role in the prevention and treatment of postoperative HCC recurrence in the foreseen furture.

This paper analyzes the distribution and achievements of the Science Foundation for Youth undertaken by female scientists at Peking University Health Science Center from 2002 to 2012.It reveals the importance of the Science Foundation for Youth in the development of female scientists.

Objective To evaluate diagnosis value and image feature of spiral CT and MRI imaging in pulmonary embolism.Methods 42 patients with pulmonary embolism diagnosed by DSA in our hospital were analyzed retrospectively.All cases were given Spiral CT and MRI angiography examination,and the diagnosis value of the two methods were compared.Results The main performance of spiral CT were pulmonary artery filling defect,distal nonimaging,and 72 embolus which were detected in arterial blood vessels and its branches;the main performance of MRI were pulmonary artery filling defect,the remote signal disappeared,and 61 embolus which were detected.In standard of DSA,the diagnosis rate of pulmonary embolism of spiral CT was 97.62％,which was obviously higher than that of MRI (x2 =5.42,P ＜ 0.05).The embolus detection rate of spiral CT was 94.74％,which was obviously higher than that of MRI(x2 =5.79,P ＜ 0.05).Diagnose embolus rate of spiral CT was 97.74％,which was obriously higher than that of MRI (x2 =4.11,P ＜ 0.05).Leakage and misdiagnosis rate of embolus of spiral CT was 5.26％,which was obriously lower than that of MRI (x2 =6.45,P ＜ 0.05).Conclusion The detection accuracy rate of spiral CT is better than that of MRI imaging.And it is convenient,safe and feasible.Spiral CT can be used as the first noninvasive detection method.

Objective To study the related factors of pancreatic infection in patients with severe acute pancereatitis(SAP).Methods 113 patients with SAP were divided into the SAP group and the infected group,and 18 factors were contrasted between the two groups.Results There were 44 patients in the SAP group and 69 patients in the infected group,There was no significant difference in gender,age,hemodiastase,blood glucose,AST,ALT,blood calcium,CRP,and mechanical ventilation between the two groups (P ＞ 0.05).But thwre were significant differences in nosogenesis,APACHE-Ⅱ score,Ranson score,CT Balthazar grading,serum albumin,Cr,BUN,central venous catheter time,and PPI application time(t =16.0496,3.9607,8.3717,8.5124,13.8177,7.0316,6.187,5.4527,3.8548,all P ＜ 0.01).Conclusion Biliary SAP,higher APACHE-Ⅱ score,higher Ranson score,higher CT Balthazar grading,lower serum albumin,higher Cr,higher BUN,longer central venous catheter time,longer PPI application time can increase the pancreatic infection rates in patients with SAP.

Objective To observe the effects of different environmental intervention on the learning-memory ability and choline acetyltransferase (ChAT) expression around the infarct in rats with unilateral local cerebral infarction.Methods SD rats were subjected to electric coagulation of MCA and then were assigned randomly to ①control group(5 in each group housed in a standard cage),②learn training group(housed in a maze cage),③enriched environment group(housed in a enriched environment cage).24 days later,rats were trained by water maze,and then killed for immunohistochemistry staining.The expression of ChAT in peri-ischemic cortex was examined.Results The escape latency of rats in enriched environment was the shortest((26.9 ± 4.8)s),and the times striding over the platform was the most(6.1 ±1.1),longer (33.6 ± 5.1)s and less (4.8 ± 1.2)in the learn training group,the longest ((41.4 ± 6.4) s) and least (3.3 ± 0.9) in the control group.The positive cells of ChAT in enriched environment group (40.3 ± 8.4) were higher than those in learn training group (35.6 ± 7.8) and those in control group (25.4 ± 6.5).Conclusion Enriched environment after MCAO could promote the learning-memory ability and up-regulate the expression of ChAT in the peri-ischemic regions.