Objective To study the reasons why PLoS One has set off an upsurge in China especially in hospitals, the academic level of papers published in PLoS One, and how to correctly judge the SCI-covered papers published by hospitals.Methods Papers published in PLoS One by hospitals in China were retrieved.The number of papers published in PLoS One by hospitals in China, the institutions that published the papers in PLoS One, and the num-ber of fund-supported papers were analyzed.Results A total of 9739 papers were published in PLoS One by hospitals in China from 2007 to October 2015, with an average cited frequency of 5.29.The majority of authors who published the papers were from affiliated hospitals of scientific research institutions and teaching hospitals of colleges and uni-versities.Of the 9739 papers, 87.78%were supported by funds from different foundations.Conclusion Nothing is strike about the academic level of papers published in PLoS One by hospitals in China with their average cited fre-quency lower than that (8.14) in our country.The SCI-covered papers published by hospitals should not be con-sidered as the only criterion in assessing the performances of staff in hospitals.

As a quantitative evaluation approach for tumor hyperthermia,thermal dosimetry is a critieat part of the treatment planning system and plays a key role in governing the relationships between thermal exposure(temperature and time of exposure)and thermal damage.Its principal theories,parameters as well as thermal dosimetry models are potentially to accurately describe the tumor hyperthermia effectiveness and therefore greatly improve the clinical experience and prescription for tumor hyperthermia.The deep study and wide clinical application of thermal dosimetry in hyperthermia will further standardize tumor hyperthermia and benefit the patients more.

[Summary] The prevalence of diabetes mellitus and osteoporosis is rapidly growing and pose a serious threat to human health,. Accumulating evidence indicates that diabetes mellitus is a risk factor for osteoporosis and they could be linked by similar pathophysiological mechanisms. Antidiabetic agents may not only help to control the chronic hyperglycemia state but can also effect bone, This article reviewed the correlation between diabetes mellitus and bone metabolism and summarized the available data on skeletal effects of clinically approved antidiabetic therapies, aimed to provide the basis for clinical medicine use.

Henoch Schonlein purpura nephritis is a systemic inflammatory response of systemic vasculitis in anaphylactoid purpura,it is often occurred in childhood with systemic vasculitis reaction.Some patients will develop nephritic syndrome or nephrotic syndrome,even kidney failure,either of which is harmful to the health of children.However,a unified standard for the diagnosis and treatment of purpura nephritis is still lack.Combined with the latest research results,this research intends to review the pathogenesis,clinical diagnosis and treatment of purpura nephritis.

There are mounting evidences demonstrating that obesity and osteoporosis pose a daunting threat on global public health problem, given their morbidity and mortality. Ω-3 polyunsaturated fatty acids ,besides as a source of energy, may regulate the cellular signal transduction pathway to produce specific patterns of gene expression, and protect from complications of obesity and osteoporosis . This article reviewed the correlation between obesity and osteoporosis, and summarized the effects and potential mechanism of ω-3 polyunsaturated fatty acids on fat metabolism and bone metabolism from both animal experiments and epidemiological studies.

OBJECTIVE:To investigate the use of antibiotics in patients undergoing hemorrhoidectomy in our hospital.METHODS:A total of 120 copies of discharge records of patients undergoing hemorrhoidectomy written by four doctors(30 copies/doctor) between Jan 2006 and Jun 2006 in proctology department were sampled and divided into four groups in accordance with different charging doctors,and a statistical analysis was carried out in respect of the drug consumption sum and medication data of these patients.RESULTS:The irrational use of antibiotics in patients undergoing hemorrhoidectomy in proctology department of our hospital manifested as unclear indications of medication,improper time of drug use,and the prolonged continuous drug use.There were significant differences among four groups in the average drug consumption sum(P

AIM: To investigate effect of endotoxin on adrenomedulin(ADM) gene transcription in vascular endothelial cells. The role of p38 mitogen-activated protein kinase (p38 MAPK) signaling pathway was also observed.METHODS: The effect of endotoxin in the presence or absence of p38 MAPK specific inhibitor SB203580 on the transcription of ADM in vascular endothelial cells ECV304 was evaluated by reverse transcription nest DNA polymerase chain reaction. RESULTS: Treatments of endotoxin (0.1, 1.0, 10, 50, 100 ?g/L) for 24 h increasea the ratios of ECV 304 ADM mRNA/? actin mRNA. The induction of ADM mRNA by endotoxin could be inhibited partially by 10 mmol/L SB203580.CONCLUSION: Endotoxin stimulated the transcription of ADM gene in vascular endothelial cells. The activation of p38 MAPK might be an important mechanism of ADM gene induced by endotoxin.

Objective To investigate the effect of methylprednisolone (MP) combined with puerarin in preventing the spinal cord ischemia-reperfusion injury (SCII).Methods The model of ischemia-repeffusion injury was established by clipping the abdominal aorta of rats for 30 min.Eighty male SD rats were randomly and equally divided into 4 groups: the blank group in which the abdominal aorta was only exposed,the positive drug group in which intravenous MP injection (30 mg/kg) was conducted 30 min before the establishment of the ischemia-reperfusion injury model,the therapy group in which intravenous MP (10 mg/kg)and puerarin (30 mg/kg) injection was conducted 30 min before the establishment of the model,and the model group in which the physiological saline equivalent to the volume of MP in the positive drug group were injected into the caudal vein of rats 30 min before the establishment of the model.Ten rats were taken from each group and the homogenation of the spinal cord was used to test expression level of superoxide dismutase (SOD) and sodium-potassium adenosinetriphosphatase (Na-K ATPase).For another 10 rats in each group,the BBB scoring system was used to evaluate the neural function of the hind limb immediately after recovery from anesthesia,12 h and 24 h after reperfusion,and the spinal cord was obtained 24 h after reperfusion to observe the morphous of the spinal cord neurons.Results The expression levels of SOD and Na-K ATPase in the model group,positive drug group and therapy group 3 h after reperfusion were significantly lower than that in the blank group; the expression levels of SOD and Na-K ATPase in positive drug group and therapy group were significantly higher than that in the model group,and there was no significant difference between the positive drug group and the therapy group with regard to the levels of SOD and Na-K ATPase.The BBB score was better in the positive drug group and the therapy group than those in the blank group and model group.Microscope observation showed that the degree of injury between positive drug group and therapy group was equivalent,while each of them was lower than that in the model group.Conclusion MP combined with puerarin plays a great role in the prevention of the SCII.

Objective To observe the clinical efficacy of esomeprazole combined with trimebutine maleate in the treatment of reflux esophagitis patients without helicobacter pylori infection.Methods 78 patients with reflux esophagitis were randomly divided into two groups,46 patients in study group and 32 patients in control group.30 minutes before the breakfast,all the patients took Nexium 20mg,twice a day.The study group was given trimebutine maleate 200mg,thrice a day additionally.The treatment course was 4 weeks.The effect and the result of gastroendoscopy were observed.Results The average time of clinical symptoms disappeared in study group was (10.51 ± 2.43) days,which was significantly shorter than (12.31 ± 3.17) days of the control group (t-2.84,P ＜ 0.01).The total effective rate of the study group was 97.83％,which was significantly higher than 81.25％ of the control group (x2 =4.48,P ＜ 0.05).Conclusion Esomeprazole combined with trimebutine maleate in the treatment of reflux esophagitis without helicobacter pylori infection can promote gastric emptying,prevent reflux,control esophageal inflammation and promote ulcer healing effectively.

AIM: To observe the effect of Yiru Granule on the female rat of hyperprolactinemia models. METHODS: Subcutaneous injection of maxolon was applied to establishing the mice model with hyperprolactinemia.Rats were at random divided into five groups,model control group,bromocriptine group,Yiru Granule of high dose,middle dose and low dose,and one normal group.The treatment lasted 30 days,serum levels of PRL,T,FSH, LH,P and E_2 were measured.Finally,the apoptosis regulatory protein bcl-2 and bax were assayed through immunohistochemical method and we used picture-analysing instrument to dispose the data. RESULTS: The middle and high dosage of Yiru Granule could not only inhibit the level of prolactin of the hyperprolactinimia rat models,but also increase the levels of estrogen and progesterone(P