Objective To investigate the technical feasibility of medical robot in application to vascular intervention. Methods The independent-developed medical robot was used in the glass vessel model and vascular intervention experiments in a dog. Results The process of experiments were smooth,the system movement did not have any malfunction,and the animal experiments did not have any operative complications. The operative time was 50 minutes.Conclusions The medical robot can basically meet the requirements of cerebral angiography. It has laid a foundation for further development of intracranial vascular interventional procedures and clinical application.

Objective: To analyze the risk factors and the prognostic factors of acute traumatic coagulopathy(TC) in patients with polytrauma. Methods: The clinical data of 180 patients with multiple trauma were analyzed.All the patients were divided into TC group and control group according to whether acute TC was occurring or not.The TC group were divided into death group and survival group according to the prognosis.The influence of age, gender, multiple trauma cause, blood index[hemoglobin(Hb), hematocrit(Hct), platelet(Plt)], coagulation index[prothrombin time(PT), activated partial thromboplastin time(APTT)], arterial blood gas index, injury severity score(ISS), acute physiology and chronic health score Ⅱ(APACHE Ⅱ), Glasgow Coma Scale(GCS) score, complicated with severe head injury(STBI), blood transfusion, use of antihypertensive drugs on TC and prognosis were analyzed. Results: There were 52 patients with TC in 180 patients with polytrauma, which accounted for 28.89%.There were 21 deaths in 52 patients with TC, which accounted for 40.38%.There were 12 deaths in 128 patients without TC, which accounted for 9.38%.The death rate of the TC patients were significantly higher than that of the non-TC patients, the difference was statistically significant(χ²=23.749, P<0.01). The differences of the ratio of Consolidate STBI, the ratio of using boost drugs, GCS≤6, Hb, Hct, Plt, ISS, APACHE Ⅱ, blood transfusion between the TC group and control group were statistically significant(χ²=45.779, 28.281, 15.626, t=5.148, 6.183, 13.366, 6.248, 9.146, 8.353, all P<0.01). logistic regression analysis showed that GCS≤6 points, complicated with STBI, Plt count were independent risk factors for acute TC in patients with polytrauma. Conclusion Emergency patients with multiple injuries are prone to TC, which has higher mortality.The GCS≤6 points, complicated with STBI and Plt count are the independent risk factors for TC.The GCS≤6 points, complicated with STBI are the independent risk factors for prognosis of TC patients.

Objective To investigate the cognitive difference between uni-modal (V,A) and bi-modal (VA)target stimuli from both vision and audition,and then to study the neural mechanisms of bi-modal enhancement.Methods This experiment adopted a speeded target stimuli detection task, both behavioral and electroencephalographic responses to uni-modal and bi-modal target stimuli which were combined from visual and auditory target stimuli,were recorded from 14 normal subjects using a 64-channel EEG NeuroScan system.The differences of cognitive between uni-modal and bi-modal stimulus were tested from both behavioral (reaction time (RT) and error rate (ER)) and event-related potentials (ERPs) (P2 latency and amplitude,P3 latency and amplitude)data,and the correlation between behavioral and ERPs results were analyzed.Results As a result,the RT,ER and P3 latency has significant difference between uni-modal and bi-modal target stimuli.In addition,there were significant correlation between behavioral data and P3 latency,especially from the RT and P3 latency.Conclusion By comparing the difference between uni-modal and bi-modal from both behavioral and ERPs results,we could reached the conclusion that the neural mechanism of bi-modal target detection was predominant over that of vision and audition uni-modal target detection,the enhancement take place not only involved in early ERP components (such as P1 and N1),but engaged at the late ERP components (such as P2 and P3).

OBJECTIVETo investigate the effect of joint mobilization on postoperative wrist joint function, pain and grip strength for elderly patients with distal radius fracture.

METHODSFrom January 2015 to June 2016, a total of 67 elderly patients with distal radius fracture were randomly divided into routine exercise group and joint mobilization group. Among them, 37 patients in the routine exercise group underwent conventional distal radius fracture postoperative joint function exercise regimen, including 16 males and 21 females with a mean age of (67.8±3.2) years old ranging from 60 to 72 years old;the injured side was dominant in 23 cases and non-dominant in 14 cases;injury mechanism was fall in 26 cases, traffic accident in 11 cases; for AO type, 6 cases were type B3, 18 cases were type C1, 7 cases were type C2, 6 cases was type C3. Other 30 patients in the joint mobilization group underwent joint mobilization on the basis of the routine exercise group including 14 males and 16 females with a mean age of (67.1±4.0) years old ranging from 61 to 74 years old; the injured side was dominant in 21 cases and non-dominant in 9 cases;injury mechanism was fall in 25 cases, traffic accident in 5 cases;for AO type, 8 cases were type B3, 13 cases were type C1, 6 cases were type C2, 9 cases were type C3. The wrist joint activity, Gartland-Werley wrist joint function score, VAS pain score and grip strength were observed at 3 months afrer treatment.

RESULTSAfter 3 months' treatment, the VAS in the routine exercise group was higher than that of the joint mobilization group (<0.05). The grip strength of affected side in both groups were lower than that of contralateral side, but the average grip strength of affected side in joint mobilization group was higher than that in routine exercise group(<0.05). In routine exercise group, the average angle of flexion, extension, radial deviation were significantly higher than those of joint mobilization group(<0.05). But ulnar deviation angle in routine exercise group compared with joint mobilization group had no significant difference (>0.05). In the comparison of each item of Gartland-Werley, there was no significant difference between two groups in residual deformity and complication(>0.05); the average score of subjective score, objective score and total score in routine exercise group were significantly higher than those of the joint mobilization group (<0.05). The wrist function Gartland-Werley score in routine exercise group after treatment was excellent in 21 cases, good in 10, 6 in fair, while in joint mobilization group, excellent in 23, good in 6, fair in 1(<0.05).

CONCLUSIONSThe application of joint mobilization in the treatment of elderly patients with distal radius fracture can improve the joint activity and obtain better wrist function after surgery.

OBJECTIVE: To observe the effect of pharyngoplasty on olfactory and taste function in treating obstructive sleep apnea hypopnea syndrome (OSAHS). METHOD: Thirty-nine patients accepted pharyngoplasty for treating OSAHS from April 2005 to December 2005 who complained of olfactory and/or taste disturbances were analyzed in this study. RESULT: Four cases complained of taste disturbances , among them, one case complained of disturbance. The 1st case complained of hyposmia, complete taste loss of sour and salty and partial taste loss of sweet. The 2nd case complained of partial taste loss of sour, sweet, salty and bitter. The 3rd case complained of partial taste loss of sour. The 4th case complained of phantogeusia who had sour and bitter sensation in phlegm. CONCLUSION The olfactory and/or taste disturbances may be complications of pharyngoplasty. Surgeons should be careful during the operation to avoid the damage of olfactory and taste function.
Adult ; Humans ; Male ; Middle Aged ; Olfaction Disorders ; etiology ; Reconstructive Surgical Procedures ; adverse effects ; Sleep Apnea, Obstructive ; surgery ; Taste Disorders ; etiology

OBJECTIVE: To determine whether there was agreement between the short daytime ApneaGraph (dAG) and nocturnal ApneaGraph (nAG) in diagnosing sleep respiratory events initially and identifying the site of obstruction in airway. METHOD: Twenty four patients diagnosed OSAHS by PSG were enrolled. The apnea-hypopnea index (AHI), apnea index (AI), obstructive apnea-hypopnea index (OAHI), central apnea hypopnea index (CAHI), mixed apnea index (MAHI), lowest oxygen saturation (LSaO2) and the proportion of upper/lower obstruction (UPPER, LOWER) of patients were measured using both dAG and nAG. RESULT: There were no significant differences between nAG and dAG for the following parameters: AHI, AI, CAHI, MAHI, OAHI, the proportion of upper/lower obstruction, or LSaO2 (P>0.05). There were significant positive correlations between nAG and dAG with regard to AHI, AI, MAHI, OAHI, the proportion of upper/lower obstruction , LSaO2 except CAHI. CONCLUSION The dAG has similar results with nAG in early diagnosis of sleep respiratory events and identifying the level of airway obstruction. The time-saving dAG is of considerable referential importance in diagnosis of sleep respiratory events and analysing the level of airway obstruction.
Adult ; Airway Obstruction ; Exercise Test ; methods ; Female ; Humans ; Male ; Middle Aged ; Polysomnography ; methods ; Sleep ; Sleep Apnea, Obstructive ; diagnosis ; physiopathology

OBJECTIVETo observe the clinical effect on treatment of premature ovarian failure (POF) patients by Bushen Tiaojing Recipe (BTR) and hormone replacement therapy (HRT).

METHODSTotally 72 POF patients were randomly assigned to three groups by random digit table, i.e., the Chinese medicine group, the Western medicine group, and the integrative medicine group, 24 in each group. Those in the Chinese medicine group took BTR. Those in the Western medicine group were treated by HRT. Those in the integrative medicine group were treated by BTR + HRT. All were treated for three courses and followed-up for 3 months after treatment. The clinical efficacy, integrals of clinical symptoms, and serum sex hormones levels [follicular stimulating hormone (FSH), estradiol (E2), luteinizing hormone (LH)] were compared among the three groups before treatment, at the end of treatment, and 3 months after withdrawal.

RESULTS(1) The total effective rate was better in the integrative medicine group than in the Chinese medicine group and the Western medicine group (P < 0.05). (2) At the end of treatment, the integrals of clinical symptoms decreased in the 3 groups when compared with before treatment in the same group (P < 0.05, P < 0.01). The integrals of clinical symptoms were higher at 3 months after withdrawal than at the end of treatment in the Western medicine group (P < 0.05). But there was no statistical difference in changes of integrals between the Chinese medicine group and the integrative medicine group (P > 0.05). (3) By the end of treatment serum E2 increased (P < 0.01), FSH and LH decreased (P < 0.01) in the three groups, more significantly in the integrative medicine group and the Western medicine group (P < 0.05, P < 0.01). At 3 months after withdrawal serum E2 decreased, FSH and LH increased in the Western medicine group, showing statistical difference when compared with the other two groups (P < 0.05, P < 0.01). There was no statistical difference in changes of serum E2, FSH, or LH between the Chinese medicine group and the integrative medicine group (P > 0.05).

CONCLUSIONSBTR combined HRT had significant effect on treatment of POF, could significantly improve patients' clinical symptoms, menstrual states, and serum sex hormones levels. It had lower recurrence rate. Patients suffered from less adverse reactions.

Adolescent ; Adult ; Drugs, Chinese Herbal ; therapeutic use ; Female ; Hormone Replacement Therapy ; Humans ; Integrative Medicine ; Phytotherapy ; Primary Ovarian Insufficiency ; drug therapy ; Young Adult

OBJECTIVETo verify the feasibility and safety of the vascular interventional vascular interventional surgical robot system applied to vascular interventional operation.

METHODSFrom March to September 2013, 10 patients had undergone robot-assisted cerebral angiography. There were 6 male and 4 female patients; aged from 19 to 58 years, with an average age of 38.4 years. The operation were carried out by neurosurgeons and vascular interventional robot. After successfully implanted of femoral artery sheath by hand, the catheter was fixed on the robot, under the guidance of navigation image the surgeon manipulate the master part and control the slave part of robot by sending command through network transmission, finally finished the whole cerebral angiography. The operation time was recorded from placing the sheath into femoral artery to finishing cerebrovascular selective angiography, simultaneously the time of staff under exposure of X ray was recorded, and the position difference between the setted targets and the actual position(positioning accuracy).

RESULTSIt took 25-41 minutes to finish the cerebral angiography, the average time was (31 ± 5) minutes, and the robot-assisted angiography went quickly and smoothly without surgical complications. The remote positioning accuracy was (1.03 ± 0.23) mm. The time of staff under exposure of X ray was 0 minute, the entire experimental process was basically implemented mechanization and automation.

CONCLUSIONThis system basically achieves initial medical purposes, such as reducing the radiation, facilitating interventional procedures on the basis of enhancing the image navigation, shorting the operation time, and improve the quality of operation.

Adult ; Female ; Humans ; Male ; Middle Aged ; Robotic Surgical Procedures ; Vascular Surgical Procedures ; instrumentation ; Young Adult

Five new terpenoids, including two vibsane-type diterpenoids (1, 2) and three iridoid allosides (3-5), together with eight known ones, were isolated from the leaves and twigs of Viburnum odoratissimum var.sessiliflorum. Their planar structures and relative configurations were determined by spectroscopic methods, especially 2D NMR techniques. The sugar moieties of the iridoids were confirmed as β-D-allose by GC analysis after acid hydrolysis and acetylation. The absolute configurations of neovibsanin Q (1) and dehydrovibsanol B (2) were determined by quantum chemical calculation of their theoretical electronic circular dichroism (ECD) spectra and Rh₂(OCOCF₃)₄-induced ECD analysis. The anti-inflammatory activities of compounds 1, 3, 4, and 5 were evaluated using an LPS-induced RAW264.7 cell model. Compounds 3suppressed the release of NO in a dose-dependent manner, with an IC₅₀ value of 55.64 μmol·L^-1. The cytotoxicities of compounds 1-5 on HCT-116 cells were assessed and the results showed that compounds 2 and 3 exhibited moderate inhibitory activities with IC₅₀ values of 13.8 and 12.3 μmol·L^-1, respectively.
Terpenes/pharmacology* ; Viburnum/chemistry* ; Molecular Structure ; Diterpenes/chemistry* ; Plant Leaves/chemistry*

Objective To investigate the clinical value of localization of upper airway obstructive site with the method of combination of nasopharyngeal airway and polysomnography (PSG).Methods Forty-seven patients diagnosed as obstructive sleep apnea hypopnea syndrome (OSAHS) by PSG were enrolled.Each patient was examined by Somte PSG for the first night,underwent repeated PSG examination with the nasopharyngeal airway in place for the second night and received airway continuous pressure measurements (ApneaGraph) examination for the third night.The standard of treatment success was defined as apnea-hypopnea index(AHI) less than 20/h and a reduction of 50％ or more.The patients were divided into success group and failure group.The PSG indices and ApneaGraph data of the two groups were compared.Correlations between AHI with nasopharyngeal airway in place by PSG and lower AHI and constituent ratio of lower obstruction by ApneaGraph were calculated.SPSS 17.0 software was used to analyze the data.Results Forty-two patients completal three-night examination.With the nasopharyngeal airway in place,AHI,the lowest oxyhemoglobin saturation (LSaO2),average oxyhemoglobin saturation,percent of sleep time with oxyhemoglobin saturation ＜ 0.90 (SaO2 ＜ 0.90T％) were improved obviously (P ＜ 0.001).Twenty-nine patients (69.0％) achieved treatment success.There were statistical differences (t =2.670,P =0.011 ;Z =-3.252,P =0.001 and t =-4.556,P ＜0.001) of LSaO2 by PSG,lower AHI and constituent ratio of lower obstruction by ApneaGraph compared success group with failure group.The correlations between AHI with nasopharyngeal airway in place by PSG and lower AHI and constituent ratio of lower obstruction by ApneaGraph were 0.616 (P ＜0.001) and 0.526 (P ＜ 0.001).Conclusion The method of combination of nasopharyngeal airway with PSG is a reliable method of localization of upper airway obstructive site and can be used as a simple means to find out if there's any retroglossal obstruction.