1.Advance and application of CRISPR/ Cas9 mediated genome editing technique on pathogenic microorganism
Dingjie AN ; Yuanhuan KANG ; Long CHEN ; Haiyue ZHANG ; Dongxing ZHANG ; Jiaxin TIAN ; Junpeng JIA ; Wuwen SUN ; Xiaofeng SHAN ; Aidong QIAN
Chinese Journal of Zoonoses 2017;33(3):280-286
Clustered regularly interspaced short palindromic repeats (CRISPR) is an acquired immune system existing in archaea and bacteria with the long-term process of evolutionary.CRISPR/Cas9 gene editing system is a new type of gene editing technology developed based on the system.CRISPR/Cas9 is a more efficient method for gene targeting than the previous methods.It has been successfully applied for gene-modified of eukaryotes since 2012,but the reports about pathogenic microorgaisms are rarely.Here,the research progress in the structure,mechanism of CRISPR/Cas9 system and its applications on pathogenic microorgaisms is reviewed.
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