Objective:To increase the medicine concentration in rat prostate by the "sound aperture effect" and site-targeted effect of ultrasound-Mediated Microbubble in order to get better therapeutic effect. Methods: 30 1-year-old male Sprague-Dawley rats were castrated and injected estradiol benzoate for 30 days and divided into three groups randomly, model group, treatment group and ultrasound-mediated microbubble group. Model group was treated with sodium chloride, treatment group was treated with EA-10 and ultrasound-mediated microbubble group was given ultrasound-mediated microbubble and EA-10. Concentration of EA-10 in prostate was measured after the prostate was taken and homogenated. Results: Concentration of EA-10 in treatment group as higher than that of in model group(P

Objective To investigate the feasibility and safety of day surgery holmium:YAG laser lithotripsy for urinary tract calculi.Methods A total of 294 cases of urinary tract calculi were treated with ureteroscopic holmium:YAG laser lithotripsy from October 2010 to September 2011.There were 147 cases for day surgery and 147 cases for inpatient surgery group.The time of waiting to be admitted,success rate,operative time,intraoperative and postoperative complications,hospitalization costs were analyzed in each group.Results The mean operative time of the day surgery group and the inpatient surgery group was 46.4± 16.5 and 52.1± 18.3 min.The difference in the mean operative time between the two groups was not statistically significant (P＞0.05).The stone free rate was not statistically significant between the day surgery group (95.9％) and the inpatient surgery group (92.5％,P＞0.05).The complication rate of the day surgery group was slightly lower than the inpatient surgery group (5.0％ VS 5.4％),but the differences between the two groups was not statistically significant (P＞0.05).The mean time of waiting to be admitted of the day surgery group was statistically shorter than the inpatient surgery group(2.5±1.3d VS 7.6±3.6 d,P＜0.05).Patients in the day surgery groups spent statistically less money than patients in the inpatient surgery group (5433.4 VS 8612.9,P＜0.05).Conclusions Day surgery for ureteroscopic holmium:YAG laser lithotripsy could be safe with lower costs and incidence of postoperative complications,faster postoperative recovery.Pre-operative adequately and selecting appropriate patients are helpful to reduce and control of intraoperative and postoperative complications.