Objective To compare the outcomes of in-vitro maturation (IVM) and in-vitro fertilization (IVF) after early follicular phase gonadotropin-releasing hormone agonist (GnRH-a)down-regulation in infertile patients with polycystic ovary syndrome (PCOS).Methods From July 2010 to December 2012,72 infertile patients with PCOS undergoing assisted reproductive technology treatment in the Affiliated First Hospital of Wenzhou Medical University were enrolled in this study.The patients were divided into 2 groups,which were patients with early follieular phase down-regulation IVM (36 cases) at IVM group and early follicular phase down-regulation long protocol IVF (36 cases) at IVF group.The laboratory parameters and clinical outcomes were compared between two groups.Results (1) Lab parameters:a total of 442 oocytes were retrieved in group IVM,and 560 were in group IVF.The rate of mature oocytes of 83.8％ (469/560) and high-quality embryos of 70.9％ (212/299) at group IVF were significantly higher than that of group IVM [54.1％ (239/442) and 50.7％ (73/144),retrospectively,P ＜0.01].In group IVM,the average duration of gonadotropin (Gn) was (2.8 ± 1.5) days and the average dosage of Gn was (285 ± 169) U,which were significantly lower than (11.0 ± 1.0) days and (1499 ±165) U in group IVF (P ＜0.01).The mean number of oocytes retrieved 12.8 ± 2.5,fertilization rate of 64.8％ (155/239),and implantation rate of 31％ (23/74) in group IVM and 15.6 ±3.1,65.5％ (307/469),31％ (23/74) in group IVF,which did not reach statistical difference (P ＞0.05).(2) Clinical outcomes:the clinical pregnancy rate (17/31,55％) of IVF group was not significantly higher than that 44％ (14/32) at IVM group (P ＞ 0.05).The abortion rate was 1/17 at Group IVF and 1/14 in group IVM,which did not show statistical difference.Women at IVM group has no ovarian hyper-stimulation syndrome (OHSS) cycle,group IVF has 31％ (11/36) cycles presented moderate and severe OHSS.Conclusions Infertile patients with PCOS undergoing IVM and IVF treatment after early follicular phase GnRH-a down-regulation can get satisfactory laboratory and clinical outcome.In addition to short treatment cycle,IVM can also avoid the occurrence of OHSS completely,but it has a rising trend in the abortion rate.IVF has a high incidence of OHSS,meanwhile,it increases the dosage of gonadotropins.

Objective To discuss the effect of super early rehabilitation care on daily life ability for patients with cerebral apoplexy .Methods A total of 120 cases of stroke patients were randomly divided into the control group and the experimental group with 60 cases in each group .The control group was given routine nursing, and the experimental group was given super early rehabilitation care .Using self-designed questionnaire , patients’ knowledge of health education and satisfaction towards nursing quality were evaluated , by internationally accepted Modified Barthel Index (MBI) and simplified Fugl-Meyer Assessment(FMA) to evaluate the patient’s motion function and daily living skills .Results The comparison of the two groups in stroke health education knowledge and patient’s satisfaction has a significant difference (90.0%vs 63.33%;95.0%vs 81.67%;χ2 =10.253,9.677,respectively;P<0.05);after four weeks, the patients in experimental group FMA score and MBI score were significantly higher than those in control group [(55.2 ±5.1) vs (36.5 ±4.2);(62.9 ±9.8) vs (42.3 ±10.6);t=3.25,3.17,respectively;P<0.05)].Conclusions Super early comprehensive rehabilitation nursing can reduce disability in patients with cerebral apoplexy , shorten the course of the disease , significantly improve stroke patients with hemiplegia limb function and ADL ability , and reduce morbidity .