1.Efficacy of mometasone furoate aqueous nasal spray combined with loratadine in pediatric allergic rhinitis and its effects on IL-10, IL-17
Chinese Journal of Biochemical Pharmaceutics 2016;36(6):67-69
Objective To study the curative efficacy of mometasone furoate aqueous nasal spray combined with loratadine in the treatment of pediatric allergic rhinitis, and its effects on IL-10, IL-17 in serum.Methods 126 patients of pediatric allergic rhinitis who were admitted in our hospital from May 2011 to September 2013 were selected as research objects and randomly divided into treatment group and control group, 63 patients in each group.The control group were treated with loratadine, while the treatment group were treated with mometasone furoate aqueous nasal spray in combination with loratadine.The curative efficacy, scores of clinical symptoms and nasal examination, curing time, medication time and serum IL-10, IL-17 levels were compared between the two groups.Results The total therapeutic efficacy ratio in the treatment group was 98.41%, which was statistically higher than that of 80.95% in the control group (P<0.05).5 weeks after the treatment, scores of sneezing, runny nose, nasal congestion, nasal itching, eye itching and nasal examination in the treatment group were statistically lower than those in the control group (P<0.05).The curing time and medication time in the observation group were statistically shorter than those in the control group ( P <0.05 ) .The inflammatory factors, in comparison with the control group after treatment, the treatment group had statistically higher level of serum IL-10 and lower level of serum IL-17 ( P <0.05 ) . Conclusion Mometasone furoate aqueous nasal spray in combination with loratadine is effective for pediatric allergic rhinitis with a high therapeutic efficacy ratio.And it could significantly improve clinical symptoms, shorten treatment time, increase level of IL-10 and reduce level of IL-17.
2.The research progress on cancer multidrug resistance mechanisms
Practical Oncology Journal 2015;(4):364-367
The multidrug resistance( MDR) has become one of the key factors in the success of chemo-therapy.Thus,overcoming multidrug resistance of tumor has become a pressing matter of the moment for tumor therapy.The mechanism of MDR is a very complicated process,influenced by many factors.Therefore,the tumor multidrug resistance mechanisms in depth study will help to select more appropriate anti-tumor drugs.In this re-view,we described about MDR mechanisms researching progress in recent years.
3.Expression of CD147, vascular endothelial growth factor C in lung squamous cell carcinoma and adenocarcinoma and their clinical significances
Cancer Research and Clinic 2016;28(5):311-314
Objective To discuss the relationships between expression levels of CD147 and vascular endothelial growth factor C (VEGF-C) in lung squamous cell carcinoma and adenocarcinoma and the clinicopathological features.Methods The expression of CD147 and VEGF-C in 57 lung cancer tissues was detected by immunohistochemical method.Results The positive expression rates of CD147 and VEGF-C in 57 lung cancer tissues were 63.16 % (36/57),66.67 % (38/57) respectively.The expression of CD147 and VEGF-C in lung squamous cell carcinoma and adenocarcinoma had no statistical difference (both P > 0.05).The expression of CD147 and VEGF-C in lung squarnous cell carcinoma and adenocarcinoma had relationship with lymph node metastasis and tumor TNM stage (all P < 0.05),however they had not correlation with the patient' s age,sex,smoking and tumor cell differentiation extent irrelevant (all P > 0.05).The expression of CD147 was related positively with VEGF-C (P < 0.01).Conclusions CD147 and VEGF-C play important roles in the progression and metastasis of lung squamous cell carcinoma and adenocarcinoma,which may have a synergistic effect.The joint detection of CD147 and VEGF-C can be used as a useful prognostic indicator in patients with lung cancer.
4.Analysis of hypersensitive C -reactive protein and serum lipid in the patients with acute cerebral infarction
Chinese Journal of Primary Medicine and Pharmacy 2015;(12):1829-1831
Objective To investigate the levels of hypersensitive C-reactive protein(hs-CRP)and serum lipid in patients with acute cerebral infarction.Methods A total of 300 patients with acute cerebral infarction and 300 healthy subjects (normal controls)were included in this study.The levels of hypersensitive C -reactive protein and serum lipid were measured and analyzed via statistics soft.Results The levels of hs-CRP,total cholesterol, triglyceride,low density lipoprotein and high density lipoprotein in the research group were (25.9 ±5.2)mmol/L, (7.5 ±2.3)mmol/L,(2.8 ±0.21)mmol/L,(0.8 ±0.1)mmol/L and (3.3 ±0.2)mmol/L respectively;The levels of hs-CRP,total cholesterol,triglyceride,low density lipoprotein and high density lipoprotein in the control group were (6.3 ±1.2)mmol/L,(4.2 ±0.2)mmol/L,(1.5 ±0.2)mmol/L,(2.2 ±1.5)mmol/L and(2.5 ±0.5)mmol/Lrespectively.There was a significant statistically difference between the two groups(t =5.9,5.1,4.8,4.6 and 4.5,all P <0.05).Multivariate Logistic regression analysis showed that total cholesterol,triglyceride,low density lipoprotein and high density lipoprotein hs-CRP were independent risk factors for the acute cerebral infarction (beta respectively 0.53,0.68,0.69,1.20,0.69;S.E were 0.23,0.16,0.28,0.24,0.25,OR values were 5.6,4.8,6.2,7.8,9.2;95%CI were 0.69 -36.8,0.57 -35.7,0.58 -38.5,0.68 -44.2,0.21 -48.2,all P <0.01).Conclusion The abnormal metabolism of serum lipid and C -reactive protein were independent risk factors in patients with acute cere-bral infarction,which should be positively treated about this.
5.Research on the virtual instrument-based heart rate detection
China Medical Equipment 2015;(4):47-48
Objective: To design a heart rate testing procedure which based on Labview. Methods:Collect the blood oxygen signals of the fingers, which keep in step with the pulse wave. Filter the signals and obtain the pregnant datum by the Labview procedures. Results: Achieve the pulse cycle“T”by Labview processing the blood oxygen signals of the fingers, and gain the heart rate by calculating the pulse in one minute(Pulse is equal to the number of heart beat in one minutes-1/T,the heart rate). Conclusion:It is an important and meaningful work to process the signals. Not only acquire the heart rate, but also prompt and diagnose the diseases of the cardiovascular system. It also can provide some meaningful diagnostic evidence.
6.Arthroscopic core decompression with autologous bone marrow induction material combined with titanium rod in the repair of stage II femoral head necrosis
Chinese Journal of Tissue Engineering Research 2015;(28):4460-4464
BACKGROUND:Although core decompression can contribute to the reconstruction of necrotic bone, its single use appears to have some deficiencies and cannot completely realize the reconstruction of the femoral head.
OBJECTIVE:To explore the effect of arthroscopic core decompression with autologous bone marrow induction material combined with titanium rod in the repair of stage II femoral head necrosis
METHODS:A retrospective analysis was performed on clinical data of 79 cases of stage II femoral head necrosis admitted at the South Branch of Tongchuan People’s Hospital from February 2011 to February 2013. According to the therapeutic methods, these cases were divided into control group (40 cases) and observation group (39 cases), and were given conventional core decompression and arthroscopic core decompression with autologous bone marrow induction material combined with titanium rod. Patients were fol owed up for 24 months, and the range of hip flexion and Harris scores on hip function and adverse events were observed and compared between two groups.
RESULTS AND CONCLUSION:Al the 79 patients successful y completed the 24-month fol ow-up. By the last fol ow-up, the range of hip flexion and Harris score were significantly higher in the observation group than the control group (P<0.05). There was no failure case due to surgical material rejection. To sum up, arthroscopic core decompression with autologous bone marrow induction material combined with titanium rod is safe and effective for repair of stage II femoral head necrosis.
7.Observation on clinical effect of acupuncture for peripheral facial paralysis in acute period and facial nerve F-wave
Journal of Acupuncture and Tuina Science 2015;(6):344-348
Objective:To observe the clinical effect of acupuncture on peripheral facial paralysis in acute period and changes in facial nerve F-wave.
Methods:A total of 148 eligible cases were randomly allocated into an observation group (n=74) and a control group (n=74) by their visiting sequence. In addition to oral Prednisone and Aciclovir tablets, patients in the observation group received point-towards-point acupuncture therapy, whereas patients in the control group received routine acupuncture therapy. The treatment was done once a day and 6 times made up a course of treatment. The efficacy evaluation was made after 2 courses. The electromyography (EMG) F-wave was monitored before and after treatment.
Results:After 2 courses of treatment, the recovery rate and total effective rate were 47.3% and 94.6% respectively in the observation group, versus 20.3% and 82.4% in the control group, showing statistical differences (P<0.01). Before treatment, the facial nerve F-wave latency on the affected side was prolonged and its frequency of occurrence was decreased in both groups. After treatment, the F-wave latency and frequency of occurrence were significantly improved in both groups (P<0.05) and there were significant between-group differences (P<0.05).
Conclusion:In addition to Western medication, point-towards-point acupuncture therapy can obtain more accurate and better effect than routine acupuncture therapy for acute peripheral facial paralysis.
8.The design of anterior guidance for anterior prostheses
Journal of Practical Stomatology 2015;(6):877-881
This article systematically introduces the basic conception,classification and physiological significance of anterior guidance for anterior prostheses.A customized incisal guidance table was introduced to record and transfer the individual value of the patient to a virtual full-adjustable articulator system.The clinic effects of the individual value and average value were also compared.
9.Research Progress of Treatment of Prolapsed Lumbar Intervertebral Disc by Acupuncture and Moxibustion
Journal of Acupuncture and Tuina Science 2004;2(5):53-58
This article reviewed information related to the treatment of lumbar intervertebral disc protrusion by acupuncture and moxibustion in recent 10 years, so as to grasp the current situation of this specific topic and provide the reference evidence for the further study. According to the related professional literature of acupuncture and moxibustion, the authors found that acupuncture and moxibustion therapy had definite therapeutic effect on the lumbar intervertebral disc protrusion. But most clinical reports were retrospective and had no uniform therapeutic effect criteria, interfering with the screening of the best therapeutic plan. The authors suggested that the study of action mechanism of acupuncture and moxibustion and the clinical prospective survey should be intensified.
10.A case report of anti-Hp therapy of gastric mucosa-associated lymphoma with secondary thrombocytosis and review of literature
Journal of Leukemia & Lymphoma 2011;20(4):215-217
Objective To improve the awareness of the treatment and mechanisms of the gastric mucosa-associated lymphoid tissue lymphoma with secondary thrombocytosis. Methods One case of gastric MALT lymphoma with secondary thrombocytosis was reported and reviewed the literatures. Results The patient received anti-Hp therapy,with remission of gastric MALT lymphoma, platelet count also will return to normal levels. Conclusion It is shown that anti-Hp therapy of gastric MALT lymphoma with secondary thrombocytosis is an effective treatment.