It was found that the Lao Shan polsaccharide P, one of the chemical components of polystictus versicolor increased the number of acetylated low density lipoprotein ( acLDL ) receptorsin the macrophages and stimulated the binding, internalization and degradation of (125I ) acLDL by the macrophages in vitro. The effect on cell degradation of ( 125I ) acLDL was dose-effect. At 100?g/ ml of the Lao Shan polysaccharide P, the effect was maximum and the degradation of ( 125I ) acLDL increased 77% ( P

Currently,there are a few problems existed in managing the research outlay of hospital including mistiness of the managing boundary,disfluency of the guarantee chain,weakness of the cost-benefit consciousness,irrationality of resource configuring,lack of supervision mechanism,etc.These problems could be resolved by strengthening the inner management of the outlay,carding the management mechanism,broadening the channel of outlay,concerning about the cost accounting,optimizing the resource configuring and founding the performance evaluation mechanism.To offer a powerful guarantee for the material effect of scientific research and to promote the continuous development of scientific research healthily,we should explore the new way of strengthening the management of the scientific research outlay incessantly.

Objective To compare biomechanical performances of parallel plate fixation and vertical plate fixation for better clinical treatment of humeral intercondylar comminuted fractures (HICF).Methods Models of T-shaped fracture were created using an osteotome at the distal end of humerus in 6 specimens of upper limb in 3 human adult cadavers.The 2 fracture models of left and right humeri in the same cadaver were respectively fixated with parallel plating and vertical plating.On a biomaterial-testing machine,a vertical load was applied onto the fixated distal humerus at a speed of 5 N/s till it reached 2000 N.The loading was repeated 3 times.Vertical compression displacement,intercondylar separating displacement,deformation of medial and lateral condyles and vertical compression stiffness were documented for statistic analyses. Results Under the same load,parallel plating led to significantly less compression displacement,separating displacement and deformation of condyles( P ＜ 0.05) but significantly greater axial compression stiffness( P ＜ 0.05) than vertical plating. Conclusion In biomechanics,parallel plate fixation has better performance than vertical plate fixation for HICF.

Objective To introduce the technique of three dimensional portal venography of multi detector row spiral CT and its clinical application in the evaluation of the portosystemic collateral shunts of liver cirrhosis. Methods All relevant literatures were retrospectively reviewed on the application of two dimensional and three dimensional reconstruction techniques such as MIP, SSD, VRT of multi detector row spiral CT to demonstrate the collateral vessels of liver cirrhosis.Results The distribution, pathway and anatomy of portosystemic collateral vessels were well shown by multi detector row spiral CT portal venography. Conclusion Multi detector row spiral CT portal venography provides excellent depiction of the anatomic characteristics of the collateral shunts and enables the continuous tracing of vascular structures, thus it is very helpful in the imaging evaluation of the collateral vessels of liver cirrhosis.

Objective:To investigate the regional cerebral blood oxygenation changes of left prefrontal lobe during dyslexic children recognizing Chinese characters. Methods:We use functional near-infrared imaging (fNIRI) technique to observe 28 dyslexic elementary school students and 19 healthy students who are not reading-impaired.Results:With fNIRI, significant activations were observed in the left prefrontal cortex of both dyslexic children and non-dyslexic children during primary processing of Chinese characters, and children with dyslexia were evoked more significantly ( P

How to select endocrine agents for patients with ER-positive/ Her-2 -positive breast cancer has been a difficult question. Increasing evidences shows a consistent results that an association between Her-2 overexpression and poor response of endocrine treatment, tamoxifen and the third generation aromatase inhibitors has the similar poor efficacy. The treatment strategy for such patients should prefer chemotherapy alone or in combination with trastuzumab, and endocrine therapy combining with trastuzumab may be the development strategy.

Gemcitabine is important pyrimidine antimetabolites drug. Ribonucleotide reductase is oneof its targets whose overexpression has been observed in several gemcitabine- resistant cell lines. Meanwhile,the NSCLC patients with high RRM1 expression levels have a relatively poor survival when treated with gem-citabine. To this day, the relationship between RRM1 expression levels in peripheral blood mononuclear cellsand gemcitabine is still uncertain and it deserves further research.

The researches of air cleaning functional coatings in pathogenic microorganism and chemical gaseous pollutants removal and indoor micro-environment improvement were reviewed.The mechanism of air cleaning was discussed.It is pointed out that the evaluation method is essential for the coatings development.

Objective To investigate the clinical significance of routine application of choledochoscope during operation of biliary duct.Methods The clinical data of 136 patients with the routine application of intraoperative choledochoscope dealing with bile duct diseases in this hospital from October 2003 to July 2009 were analyzed and summarized.Results Intraoperative choledochoscope inspection,taking stones and targeted surgery were performed in 116 cases with extrahepatic and (or) intrahepatic bile duct stones.The taking out rate of extrahepatic bile duct stones was 100% (85/85),the residual stone rates of extrahepatic and intrahepatic bile duct were 0 (0/85) and 22.6% (7/31),respectively,with the total residual stone rate was 6.0% (7/116).By using intraoperative choledochoscope,benign intrahepatic bile duct stricture was found in 13 cases,malignant extrahepatic and intrahepatic bile duct stricture in 8 cases.Four cases of hilar cholangiocarcinoma and 4 cases of common bile duct cancer,2 cases of lower segment of common bile duct polyp,3 cases of hepatolithiasis with the left hepatic bile duct carcinoma were diagnosed by biopsy via choledochoscope.Causes were confirmed by applying choledochoscope in 16 patients with obstructive jaundice.The use of choledochoscope with surgical treatment enabled benign and malignant bile duct stricture to achieve good results,without serious complications such as bile duct dilaceration,subphrenic abscess or acute cholangitis.Conclusions Using choledochoscope can tremendously reduce the residual rate of stone in biliary duct surgery,increase the definite diagnosis rate of biliary duct diseases and play a role of reasonable instruction in its treatment options.It has unique advantages in identifying causes of jaundice.It is remarkable that the role of applying choledochoscope to diagnose and cure biliary duct diseases.It should be widely used.