2.Study Progress on Embryonic Stem Cells and Adult Stem Cells Derivated into Male Germ Cells
Journal of Applied Clinical Pediatrics 2004;0(08):-
Embryonic stem cells(ESCs),a kind of totipotent cells,can differentiate into cell type of the 3 germ layers.Adult stem cells(ASCs) are pluripotent stem cells,which can self-renew and transdifferentiate into a completely different tissue derivative cells.Thus ASCs can transdifferentiate into germ cells in a certain condition.Great progress has made for the study on human ESCs.However,use of ESCs faces the immunological rejection,oncogenicity and ethical controversies problems,and these limit their uses for treatment of human diseases.On contrast,ASCs can advoid these problems,and they may have a better perspective.Germ cells as carriers of genetic materials,are worth of studying.If male germ cells can be derived from ASCs,this will open the possibilities for the use of these cells for male infertillty in clinical application.In this review,we will introduce the progress on derivation of male germ cells from ESCs and ASCs.
4.Study on Effect of Lamivudine in the Treatment of 36 Patients with CHB and HBV Carrier
Yubao LIAN ; Chunxiao WU ; Guixiang ZHOU
Herald of Medicine 2001;(6):365-366
Objective:To Study the efficacy and satety of lamivudine in the treatment of CHB and HBV carrier. Methods:All patients were divided into three groups. 21 patients with CHB were classified CHB test group(namely groupⅠ), 16 HBV carries were classified ASC test group(namely Group Ⅱ), 40 patients with CHB were CHB controlled group(namely controlled group). Both group Ⅰ and group Ⅱ received lamivudine, group Ⅰ was added protecting liver therapy. The controlled group only received protecting liver therapy. The treatment courses of three groups were one year. Results:The effective rates of group Ⅰ and group Ⅱ were higher than the controlled group in turning into negative HBeAg and HBV-DNA, both the negative-turning rate of liver functions and hepatic serology target declining fibrosis in group Ⅰ was more significant than the controlled group without severe side effect. Conclusion:Lamivudin is efficient and safe medicine in the treatment of CHB and HBV carrier.
5.Investigation on the Prevalence of Xerostomia in 200 AIDS Patients
Kunli WU ; Guanglan MA ; Lian XUE
Journal of Kunming Medical University 2013;(8):144-146
Objective To investigate the incidence of xerostomia in patients with acquired immune deficiency syndromes (AIDS), clarify the association between AIDS and xerostomia to promote AIDS patients' oral health. Method The oral health conditions of 200 hospitalized AIDS patients were investigated by a self-designed evaluation form. Results Among 200 patients, xerostomia occurred in 113 (56.6%) . Among the xerostomia patients, 32.7% were without brushing habits, 63.7% with long-term medication and 43.1% (31 cases) with mainly antibiotics, antivirals and antifungal drugs. 30 (31.9%) patients with xerostomia were mainly associated with symptoms of oral burning, lips dry and scaly, periodontitis, oral mucosal dryness and tooth loss. Conclusions AIDS could increase the incidence of xerostomia. Some effective measures should be taken to promote patients' oral health, including improving AIDS patients' awareness of oral health, close observation of adverse reactions after treatment,looking for related causes, timely and targeted therapies,early detection and treatment of associated symptoms.
6.Application and nursing care of bronchoalveolar lavage by fiberoptic bronchoscopy in patients with mechanical ventilation
Junyong WU ; Lian LI ; Youping QIAO
Chinese Journal of Practical Nursing 2011;27(10):13-15
Objective To investigate the application and nursing care of bronchoalveolar lavage (BAL)by fiberoptic bronchoscopy in patients with mechanical ventilation. Methods 64 patients with mechanical ventilation in RICU were randomly divided into the control group and the observation group with 32 patients in each group. The patients in both groups were accepted anti-infection, atomization inhalation and other supportive treatments. The patients in the observation group were treated with BAL, and the patients in the control group accepted routine treatment. The therapeutic effects in the two groups were evaluated and compared. Results There was significant difference in the recovery rate and effective rate, the blood gas analysis compared with the control group was significantly improved, the time of pulmonary infection control window, mechanical ventilation, length of stay were shorter than the control group. The case number to remove ventilator successfully, organs failure and hospital mortality were less than the control group. Conclusions Fiberoptic bronchoscopy with BAL treatment could be safety and efficacy for patients with mechanical ventilation. Nursing intervention plays an important role and a good therapeutic effect for improving achievement ratio of BAL.
7.Effects of individualized nursing on the negative mood and quality of life of patients with hemoptysis
Lian LI ; Junyong WU ; Caifeng CHEN
Chinese Journal of Practical Nursing 2010;26(35):14-16
Objective To study the effects of individualized nursing on the anxiety, depression mood, quality of life of patients with hemoptysis. Methods Sixty patients with hemoptysis were randomized into the intervention group and the control group with 25 cases in each. The control group received single conventional therapy while the intervention group was given individualized nursing intervention besides the conventional therapy. Using SDS, SAS and SF-36 Life Quality Measuring Scale to evaluate the effects of the patients in both groups on admission and prior to discharge. Results The scores of anxiety and depression among the intervention group were lower than those of the control group after intervention.The dimensions of quality of life besides the physical function and bodily pain in the intervention group were significantly different after intervention. Conclusions The individualized nursing intervention can improve quality of care, the state of anxiety, depression and the quality of life of patients with hemoptysis.
8.Research in effect of health education to family members of patients with chronic heart failure WU
Yun WU ; Aiju LIN ; Xiaocui LIAN
Chinese Journal of Practical Nursing 2010;26(32):67-68
Objective To discuss the effect of health education to family members of patients with chronic heart failure. Methods 150 patients with family members as accompanies were divided into the observation group and the control group with 75 patients in each group. Health education was given to patients as well as their family members in the observation group, while health education was given only to the patients in the control group. The mastering of disease-related knowledge by family members of the observation group was observed after 15 days. The rehospitalization of the two groups by telephone follow-up was carried out six months after discharge. Results The mastering of disease-related knowledge by family members of the observation group was better compared with before health education. The rehospitalization rate of the observation group was 13.3%, which was lower than 44.0% of the control group. Conclusions Health education to family members of patients with chronic heart failure can increase treatment effect of patients, decrease disease relapse and lower rehospitalization rate.
9.Change of Thyroid Hormone and its Meaning in Patients with Chronic Heart Failure
Zhifeng WU ; Yuan LIAN ; Hongqiu HUANG
Chinese Journal of Primary Medicine and Pharmacy 2010;17(19):2625-2627
Objective To investigate the clinical significance between congestive heart failure (CHF) and serum thyroxine. Methods 50 patients with CHF (7 cases of grade Ⅱ heart function,grade Ⅲ 19 cases,grade Ⅳ 24)and 30 normal persons wre selected. The serum triiodothyronine( T3 ), four-triiodothyronine( T4 ), free triiodothyronine (FT3), free triiodothyronine (FT4), thyroid stimulating hormone TSH were determined by radioimmunoassay. Results The T3, FT3 contens ( 1.95 ± 0.55) nmol/L, (2.20 ± 0.39 ) pmol/L in CHF group were lower than the control group (2.4 ± 0.50) nmol/L, ( 5.89 ± 0. 45 ) pmol/L ( t = 2. 415,2. 325, P < 0.05 ); The T3, FT3 contens ( 2.19 ± 0. 53 )nmol/L,(3.69 ± 0.57)pmol/L after treatment were significantly higher than that before treatment (t =2. 375,2. 405, P < 0.05 ); The T3, FT3 contens in cardiac function with stage Ⅳ ( 1.76 ± 0.7) nmol/L, ( 1.99 ± 0. 45 ) pmol/L were significantly lower than the control group( t = 2.245,2. 375, P < 0.05 ); Serum TT3, TT4 and cardiac function was negatively correlated ( r = -0.933, -0.383, all P < 0.05 ) , serum FT3, FT4,TSH and cardiac function were not correlated. Conclusion The changes of serum thyroid level could be used as an index of the severity of heart failure.
10.Case of progressive spinal muscular atrophy.
Chinese Acupuncture & Moxibustion 2014;34(7):690-690