Objective: To study and analyze the influence of atorvastatin combined trimetazidine on levels of blood lipids,inflammatory factors and cardiac function in patients with coronary heart disease (CHD).Methods: A total of 128 CHD patients treated in our hospital from May 2015 to Oct 2016 were selected.According to random number table, they were randomly and equally divided into trimetazidine group (received trimetazidine based on routine treatment) and combined treatment group (received atorvastatin based on trimetazidine group).Both groups were treated for three months.Levels of blood lipids, inflammatory factors and cardiac function were measured and compared between two groups before and after treatment.Results: Compared with trimetazidine group after treatment, there were significant reductions in levels of triglyceride [(2.11±0.73) mmol/L vs.(1.83±0.77)mmol/L], total cholesterol [(5.14±0.96)mmol/L vs.(4.35±0.73)mmol/L], low density lipoprotein cholesterol [(2.35±0.68) mmol/L vs.(1.90±0.34) mmol/L], N terminal pro B type natriuretic peptide [(296.61±28.96) pg/ml vs.(187.53±32.63) pg/ml], fibrinogen [(4.44±0.34) g/L vs.(3.63±0.54) g/L] and high sensitive C reactive protein [(2.41±0.96) mg/L vs.(1.96±0.82) mg/L], left ventricular end-diastolic dimension [(59.25±6.17)mm vs.(48.43±4.28)mm] and left ventricular posterior wall thickness [(11.01±1.08)mm vs.(9.05±1.04)mm], and significant rise in level of high density lipoprotein cholesterol [(1.32±0.25)mmol/L vs.(1.47±0.38)mmol/L] and left ventricular ejection fraction [(41.28±7.04)% vs.(48.66±7.54)%] in combined treatment group, P<0.05 or <0.01.Conclusion: Atorvastatin combined trimetazidine can significantly improve blood lipid, inflammatory factor levels,cardiac function and cardiac structure in CHD patients.The therapeutic effect is significant, which is worth extending.

Objective To investigate the expression of nm23,integrin ? 5? 1 and VEGF in breast cancer(BC),and the effect of the expression on the development of BC. Methods The expression of nm23, integrin ? 5? 1 and VEGF in 51 patients with breast cancer were examined by immunohistochemistry,and their correlatios were ananlyzed. Results The low expression of nm23 in BC tissue was associated with lymph nodes metastasis. The low expression of integrin ? 5? 1 and the high expression of VEGF in BC tissues were associated with the lymph nodes metastasis and low differentiation of the tumor.The expression of nm23 and integrin ? 5? 1 in breast cancer tissues had positive correlation(P

[Summary] Hyperuricemia is a syndrome caused by increased production or reduced excretion of uric acid which is characterized by oliguria, anuria, and uremia. Recent studies found that hyperuricemia was correlated with the risk, recurrence, metastasis, and prognosis of cancer. The mechanism may be uric acid associated chronic inflammation and decrease of xanthine oxidoreductase expression in cancer cells. Current treatment of hyperuricemia is to reduce the production of uric acid by inhibition of xanthine oxidoreductase, but the side effects of systemic inhibition of xanthine oxidoreductase received more and more attention. These unwanted side effects underscore the urgent need for mechanism based preclinical studies that can identify optimal strategies for management of hyperuricemia in relevant cancer models.

There is still no agreed standard of care for CD30+ T-cell lymphomas which are dominant in peripheral T-cell lymphoma.The combination of multidrug or dose-intensified chemotherapy regimen and consolidation of hematopoietic stem cell transplantation are widely used at present.In recent years,several clinical trails included certain new agents,such as etoposide,alemtuzumab,denileukin diftitox,bortezomib,romidepsin,lenalidomide,brentuximab vedotin,and so on,have demonstrated the promising outcome.Referring targeted therapies for relapsed/refractory CD30 + T-cell lymphomas,certain agents have been approved,such as pralatrexate,romidepsin,brentuximab vedotin (ALCL),belinostat,and the most encouraging agent is brentuximab vedotin.

Objective To assess the efficacy and safety of stenting ureteral stent prior to extracorporeal shock wave lithotrip‐sy(ESWL) for non‐obstructive upper ureter and renal stone .Methods From January 2012 to October 2013 ,a total of 96 patients who met inclusion and exclusion criteria were randomly devided into two groups :a stented group (group B) with a double‐J ureter stent fixed pre‐ESWL and a non‐stented group (group A) treated with ESWL direactly .Outcomes were evaluated in 1 month and then the ureter stent was removed ,another evaluation was taken after 2 months .Results The clearance rate in group A was signifi‐cant higher than that of group B at first month(P=0 .02) ,but group B was significant higher than that of group A at the second month(P=0 .001) .The renal colic rate of group A was significant higher than that of group B(P=0 .001) ,the gross hematuria rate of group B was significant higher than that of group A(P=0 .005) .The comparison of fever ,steinstrasse ,lower urinary tract syn‐drome showed no statistical difference(P>0 .05) .Conclusion Stenting ureter stent may increase the clearance rate of ESWL by 1 session for non‐obstructive upper ureter and renal stone ,but the passage of stones mainly happen after the removing of stent .Stent‐ing can also prevent the morbidity of renal colic without increasing low urinary tract syndrome ,but can increase the morbidity of gross hematuira .

In the paper, 32 lots of intravenous immunoglobulin (IVIG)were tested by an animal model,the hypotensive test of rats. A linear correlation was found between prekallikrein activator (PKA)activity and hypotensive reaction if the inflow of human IVIG was made rapid (r=0.96,n=23). The preliminary observations indicated that it would be satisfactory that the PKA activity was below 35IU/ ml and the size of reduction in blood pressure was not 15% higher than that of control animal's level.The rat model can provide a method for safe usage of the intravenous immunoglobulin and reliable detection of and control over the residual PKA activity in blood products.

HER2 and P-gp are expressed in most of the human osteosarcoma tissue. The multidrug resistance of osteosarcoma is mediated by P-gp. The insusceptibility of human osteosarcoma to chemotherapy and the poor prognosis is correlated with the expression of P-gp. The expression of the carcinogene HER2 is a prognostic risk factor of the malignancy and metastasis of osteosarcoma. The review will narrate the expression of the HER2 and P-gp in osteosarcoma and its prognostic significance.

Follicular lymphoma (FL) is a subtype of B cell lymphoma,which derived from follicular germinal center.As the most common type of indolent lymphoma,the overall prognosis of FL is good.However,the prognosis of FL is heterogeneous.With the application of rituximab,the therapeutic effect and the prognosis of the disease is further improved.For the relapsed / refractory patients,especially who have received first-line chemotherapy with rituximab in the early,transplantation is an important choice.Compared with the previous conventional myeloablative conditioning regimen,reduced-intensity conditioning (RIC) effectively reduced the non-relapse mortality (NRM),extended the allogeneic transplantation recipients,but the high rate of relapse after transplantation is the main defect.The application of donor lymphocyte infusion after transplantation therapy not only can reduce the recurrence rate but also treat the disease relapse.In the future,the improvement of transplantation strategy and the application of new drugs may bring new ideas and opportunities for FL therapy.

It is related to the treatment effect of the disease and the quality of life of the patient that perioperative management of ruptured esophagogastric varices bleeding with portal hypertension.According to the individual characteristics of the patient combined with the experience of the surgeons,the key points of individualized treatment consist of accurate and comprehensive preoperative preparation,fine post-operative treatment,and the changes of pre-and post-operative hemodynamics of portal vein system to choose a reasonable procedure,meanwhile,the delicate postoperative managements can improve the surgical effect of portal hypertension.

Viral infections remain a major cause of morbidity in patients with immunodeficiency,such as recipients of hematopoietic stem cell transplantation (HSCT).Adoptive transfer of donor-derived virusspecific cytotoxic T lymphocytes is a strategy to restore virus-specific immunity to prevent or treat viral diseases and has been tested in the clinical setting for more than 20 years.The 55th ASH annual meeting reported lots of basic and clinical experience about CTL and summarized lots of trails to evaluate it,which will give us some new thought about the antivirus therapy after HSCT.